SMAD family member 3

mammalian protein found in Mus musculus

Protein protein Q14903978

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SMAD family member 3

Summary

SMAD family member 3 is a protein^[1].

Key Facts

SMAD family member 3's instance of is recorded as protein^[2].
SMAD family member 3's subclass of is recorded as protein^[3].
SMAD family member 3's UniProt protein ID is recorded as Q8BUN5^[4].
SMAD family member 3's part of is recorded as SMAD-like domain superfamily^[5].
SMAD family member 3's part of is recorded as Dwarfin^[6].
SMAD family member 3's part of is recorded as SMAD MH1 domain superfamily^[7].
SMAD family member 3's part of is recorded as SMAD/FHA domain superfamily^[8].
SMAD family member 3's part of is recorded as MAD homology, MH1, protein family^[9].
SMAD family member 3's part of is recorded as SMAD domain, Dwarfin-type, protein family^[10].
SMAD family member 3's part of is recorded as MAD homology 1, Dwarfin-type, protein family^[11].
SMAD family member 3's has part is recorded as MAD homology 1, Dwarfin-type^[12].
SMAD family member 3's has part is recorded as MAD homology, MH1^[13].
SMAD family member 3's has part is recorded as SMAD domain, Dwarfin-type^[14].
SMAD family member 3's RefSeq protein ID is recorded as NP_058049^[15].
SMAD family member 3's RefSeq protein ID is recorded as XP_006510882^[16].
SMAD family member 3's RefSeq protein ID is recorded as XP_006510884^[17].
SMAD family member 3's molecular function is recorded as phosphatase binding^[18].
SMAD family member 3's molecular function is recorded as DNA-binding transcription factor activity^[19].
SMAD family member 3's molecular function is recorded as RNA polymerase II general transcription initiation factor activity^[20].
SMAD family member 3's molecular function is recorded as R-SMAD binding^[21].
SMAD family member 3's molecular function is recorded as co-SMAD binding^[22].
SMAD family member 3's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[23].
SMAD family member 3's molecular function is recorded as transcription factor binding^[24].
SMAD family member 3's molecular function is recorded as metal ion binding^[25].
SMAD family member 3's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of SMAD-like domain superfamily, Dwarfin, SMAD MH1 domain superfamily, SMAD/FHA domain superfamily, MAD homology, MH1, protein family, SMAD domain, Dwarfin-type, protein family, MAD homology 1, Dwarfin-type, protein family

Properties

Biological process somitogenesis, skeletal system development, ureteric bud development, endoderm development, regulation of transforming growth factor beta2 production, embryonic pattern specification, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, negative regulation of osteoblast differentiation, heart looping, positive regulation of chondrocyte differentiation, pericardium development, regulation of binding, negative regulation of wound healing, activation of cysteine-type endopeptidase activity involved in apoptotic process, transforming growth factor beta receptor signaling pathway, negative regulation of inflammatory response, negative regulation of fat cell differentiation, cell-cell junction organization, regulation of transcription, DNA-templated, SMAD protein signal transduction, extrinsic apoptotic signaling pathway, in utero embryonic development, transcription, DNA-templated, nodal signaling pathway, positive regulation of transcription, DNA-templated, negative regulation of cell growth, regulation of immune response, T cell activation, activin receptor signaling pathway, regulation of striated muscle tissue development, SMAD protein complex assembly, embryonic foregut morphogenesis, positive regulation of extracellular matrix assembly, negative regulation of transcription by RNA polymerase II, positive regulation of epithelial to mesenchymal transition, mitigation of host defenses by virus, thyroid gland development, developmental growth, lens fiber cell differentiation, gastrulation, osteoblast differentiation, immune response, negative regulation of osteoblast proliferation, osteoblast development, embryonic cranial skeleton morphogenesis, paraxial mesoderm morphogenesis, response to hypoxia, mesoderm formation, regulation of transforming growth factor beta receptor signaling pathway, positive regulation of gene expression, immune system development, liver development, regulation of epithelial cell proliferation, positive regulation of transcription by RNA polymerase II, negative regulation of mitotic cell cycle, positive regulation of nitric oxide biosynthetic process, negative regulation of cytosolic calcium ion concentration, positive regulation of pri-miRNA transcription by RNA polymerase II, cellular response to transforming growth factor beta stimulus, negative regulation of cell population proliferation, positive regulation of alkaline phosphatase activity, signal transduction involved in regulation of gene expression, adrenal gland development, positive regulation of cell migration, positive regulation of bone mineralization, positive regulation of interleukin-1 beta production, positive regulation of transforming growth factor beta3 production, negative regulation of protein catabolic process, negative regulation of apoptotic process, protein stabilization, positive regulation of positive chemotaxis, positive regulation of stress fiber assembly, positive regulation of focal adhesion assembly, canonical Wnt signaling pathway, transdifferentiation, negative regulation of lung blood pressure, positive regulation of canonical Wnt signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, negative regulation of cardiac muscle hypertrophy in response to stress, adrenal gland development

Cell component cytoplasm, nucleus, heteromeric SMAD protein complex, SMAD protein complex, transcription regulator complex, receptor complex, plasma membrane, intracellular anatomical structure, nucleoplasm, nuclear inner membrane, cytosol, protein-containing complex, cytosol, nucleoplasm

Encoded by Smad3

Found in taxon house mouse

Has part(s) MAD homology 1, Dwarfin-type, MAD homology, MH1, SMAD domain, Dwarfin-type

Imported from wholeness_audit_2026-05-02

Molecular function phosphatase binding, DNA-binding transcription factor activity, RNA polymerase II general transcription initiation factor activity, R-SMAD binding, co-SMAD binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription factor binding, metal ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transforming growth factor beta receptor binding, protein homodimerization activity, collagen binding, zinc ion binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, protein binding, double-stranded DNA binding, protein kinase binding, sequence-specific DNA binding, bHLH transcription factor binding, ubiquitin binding, identical protein binding, protein heterodimerization activity, chromatin DNA binding, ubiquitin protein ligase binding, DEAD/H-box RNA helicase binding, mineralocorticoid receptor binding, glucocorticoid receptor binding, primary miRNA binding, DNA binding, beta-catenin binding, enzyme binding, SMAD binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription coregulator activity, RNA polymerase II general transcription initiation factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000034973, ENSMUSP00000116790, ENSMUSP00000121671, ENSMUSP00000122217

Refseq protein id NP_058049, XP_006510882, XP_006510884

Uniprot protein id Q8BUN5

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SMAD family member 3 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ SMAD family member 3 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ SMAD family member 3 — UniProt protein ID (P352): Q8BUN5. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ SMAD family member 3 — part of (P361): SMAD-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ SMAD family member 3 — part of (P361): Dwarfin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ SMAD family member 3 — part of (P361): SMAD MH1 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ SMAD family member 3 — part of (P361): SMAD/FHA domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ SMAD family member 3 — part of (P361): MAD homology, MH1, protein family. wikidata.org.
[10] ↑ SMAD family member 3 — part of (P361): SMAD domain, Dwarfin-type, protein family. wikidata.org.
[11] ↑ SMAD family member 3 — part of (P361): MAD homology 1, Dwarfin-type, protein family. wikidata.org.
[12] ↑ SMAD family member 3 — has part(s) (P527): MAD homology 1, Dwarfin-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ SMAD family member 3 — has part(s) (P527): MAD homology, MH1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ SMAD family member 3 — has part(s) (P527): SMAD domain, Dwarfin-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ SMAD family member 3 — RefSeq protein ID (P637): NP_058049. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ SMAD family member 3 — RefSeq protein ID (P637): XP_006510882. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ SMAD family member 3 — RefSeq protein ID (P637): XP_006510884. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ SMAD family member 3 — molecular function (P680): phosphatase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ SMAD family member 3 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ SMAD family member 3 — molecular function (P680): RNA polymerase II general transcription initiation factor activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ SMAD family member 3 — molecular function (P680): R-SMAD binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ SMAD family member 3 — molecular function (P680): co-SMAD binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ SMAD family member 3 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ SMAD family member 3 — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ SMAD family member 3 — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ SMAD family member 3 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ SMAD family member 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). SMAD family member 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/smad-family-member-3-q14903978

MLA

“SMAD family member 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/smad-family-member-3-q14903978.

BibTeX

@misc{4ortxyz_smad-family-member-3-q14903978_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SMAD family member 3}}, year = {2026}, url = {https://4ort.xyz/entity/smad-family-member-3-q14903978}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SMAD family member 3 — https://4ort.xyz/entity/smad-family-member-3-q14903978 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/smad-family-member-3-q14903978 · Last refreshed: May 3, 2026