Signal transducer and activator of transcription 3

mammalian protein found in Mus musculus

Protein protein Q14912021

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Signal transducer and activator of transcription 3

Summary

Signal transducer and activator of transcription 3 is a protein^[1].

Key Facts

Signal transducer and activator of transcription 3's instance of is recorded as protein^[2].
Signal transducer and activator of transcription 3's subclass of is recorded as protein^[3].
Signal transducer and activator of transcription 3's UniProt protein ID is recorded as P42227^[4].
Signal transducer and activator of transcription 3's part of is recorded as p53-like transcription factor, DNA-binding^[5].
Signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, DNA-binding, N-terminal^[6].
Signal transducer and activator of transcription 3's part of is recorded as transcription factor STAT^[7].
Signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, coiled coil^[8].
Signal transducer and activator of transcription 3's part of is recorded as SH2 domain superfamily^[9].
Signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, N-terminal domain superfamily^[10].
Signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, protein interaction, protein family^[11].
Signal transducer and activator of transcription 3's part of is recorded as SH2 domain, protein family^[12].
Signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, DNA-binding domain, protein family^[13].
Signal transducer and activator of transcription 3's part of is recorded as STAT3, SH2 domain, protein family^[14].
Signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, all-alpha domain, protein family^[15].
Signal transducer and activator of transcription 3's has part is recorded as STAT transcription factor, DNA-binding^[16].
Signal transducer and activator of transcription 3's has part is recorded as SH2 domain^[17].
Signal transducer and activator of transcription 3's has part is recorded as STAT transcription factor, all-alpha domain^[18].
Signal transducer and activator of transcription 3's has part is recorded as STAT transcription factor, protein interaction^[19].
Signal transducer and activator of transcription 3's has part is recorded as STAT3, SH2 domain^[20].
Signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_035616^[21].
Signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_998824^[22].
Signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_998825^[23].
Signal transducer and activator of transcription 3's RefSeq protein ID is recorded as XP_011247148^[24].
Signal transducer and activator of transcription 3's PDB structure ID is recorded as 1BG1^[25].
Signal transducer and activator of transcription 3's PDB structure ID is recorded as 3CWG^[26].

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Subclass of protein

Part of p53-like transcription factor, DNA-binding, STAT transcription factor, DNA-binding, N-terminal, transcription factor STAT, STAT transcription factor, coiled coil, SH2 domain superfamily, STAT transcription factor, N-terminal domain superfamily, STAT transcription factor, protein interaction, protein family, SH2 domain, protein family, STAT transcription factor, DNA-binding domain, protein family, STAT3, SH2 domain, protein family, STAT transcription factor, all-alpha domain, protein family

Properties

Biological process negative regulation of neuron migration, receptor signaling pathway via JAK-STAT, response to estradiol, negative regulation of glycolytic process, regulation of transcription, DNA-templated, sexual reproduction, response to organic cyclic compound, eating behavior, protein import into nucleus, phosphorylation, glucose homeostasis, regulation of multicellular organism growth, cytokine-mediated signaling pathway, leptin-mediated signaling pathway, cellular response to organic cyclic compound, ageing, negative regulation of apoptotic process, response to peptide hormone, regulation of feeding behavior, transcription by RNA polymerase II, response to organic substance, transcription, DNA-templated, cellular response to leptin stimulus, cellular response to cytokine stimulus, regulation of cell cycle, radial glial cell differentiation, stem cell population maintenance, interleukin-6-mediated signaling pathway, intracellular receptor signaling pathway, cellular response to hormone stimulus, astrocyte differentiation, growth hormone receptor signaling pathway, eye photoreceptor cell differentiation, acute-phase response, energy homeostasis, temperature homeostasis, cell population proliferation, response to leptin, response to ethanol, signal transduction, negative regulation of cell population proliferation, positive regulation of Notch signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of gene silencing by miRNA, negative regulation of stem cell differentiation, miRNA-mediated gene silencing by inhibition of translation, positive regulation of gene expression, mRNA transcription by RNA polymerase II, positive regulation of metalloendopeptidase activity, inflammatory response, positive regulation of transcription, DNA-templated, T-helper 17 cell lineage commitment, positive regulation of erythrocyte differentiation, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of angiogenesis, growth hormone receptor signaling pathway via JAK-STAT, positive regulation of vascular endothelial cell proliferation, positive regulation of cell population proliferation, negative regulation of hydrogen peroxide biosynthetic process, response to cytokine, regulation of mitochondrial membrane permeability, negative regulation of cell death, negative regulation of neuron death, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of ATP biosynthetic process, modulation of chemical synaptic transmission, postsynapse to nucleus signaling pathway, positive regulation of cell migration, modulation of chemical synaptic transmission, postsynapse to nucleus signaling pathway, positive regulation of cell migration, positive regulation of NF-kappaB transcription factor activity, negative regulation of autophagy, positive regulation of NF-kappaB transcription factor activity, negative regulation of autophagy, defense response, receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, leptin-mediated signaling pathway, regulation of cell population proliferation, response to peptide hormone, positive regulation of transcription by RNA polymerase II, growth hormone receptor signaling pathway via JAK-STAT

Cell component cytoplasm, plasma membrane, nucleoplasm, RNA polymerase II transcription regulator complex, nucleus, cytosol, mitochondrion, mitochondrial inner membrane, postsynaptic density, Schaffer collateral - CA1 synapse, glutamatergic synapse, postsynaptic density, Schaffer collateral - CA1 synapse, glutamatergic synapse, transcription regulator complex, transcription regulator complex, nucleus, cytosol

Encoded by Stat3

Found in taxon house mouse

Has part(s) STAT transcription factor, DNA-binding, SH2 domain, STAT transcription factor, all-alpha domain, STAT transcription factor, protein interaction, STAT3, SH2 domain

Imported from wholeness_audit_2026-05-02

Molecular function protein dimerization activity, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, nuclear receptor activity, protein binding, DNA-binding transcription factor activity, RNA polymerase II-specific, protein phosphatase binding, chromatin DNA binding, protein kinase binding, DNA-binding transcription factor activity, protein homodimerization activity, identical protein binding, DNA binding, CCR5 chemokine receptor binding, glucocorticoid receptor binding, sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (4)

Ensembl protein id ENSMUSP00000090342, ENSMUSP00000120152, ENSMUSP00000099403, ENSMUSP00000121677

Pdb structure id 1BG1, 3CWG, 4E68, 4ZIA

Refseq protein id NP_035616, NP_998824, NP_998825, XP_011247148

Uniprot protein id P42227

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Signal transducer and activator of transcription 3 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Signal transducer and activator of transcription 3 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Signal transducer and activator of transcription 3 — UniProt protein ID (P352): P42227. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Signal transducer and activator of transcription 3 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, DNA-binding, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Signal transducer and activator of transcription 3 — part of (P361): transcription factor STAT. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, coiled coil. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Signal transducer and activator of transcription 3 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, N-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, protein interaction, protein family. wikidata.org.
[12] ↑ Signal transducer and activator of transcription 3 — part of (P361): SH2 domain, protein family. wikidata.org.
[13] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, DNA-binding domain, protein family. wikidata.org.
[14] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT3, SH2 domain, protein family. wikidata.org.
[15] ↑ Signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, all-alpha domain, protein family. wikidata.org.
[16] ↑ Signal transducer and activator of transcription 3 — has part(s) (P527): STAT transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Signal transducer and activator of transcription 3 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Signal transducer and activator of transcription 3 — has part(s) (P527): STAT transcription factor, all-alpha domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Signal transducer and activator of transcription 3 — has part(s) (P527): STAT transcription factor, protein interaction. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Signal transducer and activator of transcription 3 — has part(s) (P527): STAT3, SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_035616. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_998824. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_998825. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Signal transducer and activator of transcription 3 — RefSeq protein ID (P637): XP_011247148. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ Signal transducer and activator of transcription 3 — PDB structure ID (P638): 1BG1. Q905695. Retrieved 2016-08-10. wikidata.org.
[26] ↑ Signal transducer and activator of transcription 3 — PDB structure ID (P638): 3CWG. Q905695. Retrieved 2016-08-10. wikidata.org.

Class ancestry

[1] ↑ Signal transducer and activator of transcription 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Signal transducer and activator of transcription 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3-q14912021

MLA

“Signal transducer and activator of transcription 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3-q14912021.

BibTeX

@misc{4ortxyz_signal-transducer-and-activator-of-transcription-3-q14912021_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Signal transducer and activator of transcription 3}}, year = {2026}, url = {https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3-q14912021}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Signal transducer and activator of transcription 3 — https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3-q14912021 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3-q14912021 · Last refreshed: May 3, 2026