SET domain containing 2, histone lysine methyltransferase

mammalian protein found in Homo sapiens

Protein protein Q21118252

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SET domain containing 2, histone lysine methyltransferase

Summary

SET domain containing 2, histone lysine methyltransferase is a protein^[1].

Key Facts

SET domain containing 2, histone lysine methyltransferase's instance of is recorded as protein^[2].
SET domain containing 2, histone lysine methyltransferase's UniProt protein ID is recorded as Q9BYW2^[3].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as WW domain superfamily^[4].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as TFIIS/LEDGF domain superfamily^[5].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as Set2 Rpb1 interacting domain superfamily^[6].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as Post-SET domain, protein family^[7].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as Set2 Rpb1 interacting domain, protein family^[8].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as SET domain, protein family^[9].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as WW domain, protein family^[10].
SET domain containing 2, histone lysine methyltransferase's part of is recorded as AWS domain, protein family^[11].
SET domain containing 2, histone lysine methyltransferase's MeSH descriptor ID is recorded as C521636^[12].
SET domain containing 2, histone lysine methyltransferase's has part is recorded as AWS domain^[13].
SET domain containing 2, histone lysine methyltransferase's has part is recorded as WW domain^[14].
SET domain containing 2, histone lysine methyltransferase's has part is recorded as SET domain^[15].
SET domain containing 2, histone lysine methyltransferase's has part is recorded as Set2 Rpb1 interacting domain^[16].
SET domain containing 2, histone lysine methyltransferase's has part is recorded as Post-SET domain^[17].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as NP_054878^[18].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as XP_011531934^[19].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as XP_011531936^[20].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as NP_001336299^[21].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as XP_024309255^[22].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as XP_024309256^[23].
SET domain containing 2, histone lysine methyltransferase's RefSeq protein ID is recorded as XP_024309257^[24].
SET domain containing 2, histone lysine methyltransferase's PDB structure ID is recorded as 2A7O^[25].
SET domain containing 2, histone lysine methyltransferase's PDB structure ID is recorded as 2MDC^[26].

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Quick Facts

Instance of protein

Part of WW domain superfamily, TFIIS/LEDGF domain superfamily, Set2 Rpb1 interacting domain superfamily, Post-SET domain, protein family, Set2 Rpb1 interacting domain, protein family, SET domain, protein family, WW domain, protein family, AWS domain, protein family

Properties

Biological process regulation of transcription, DNA-templated, histone H3-K36 dimethylation, regulation of mRNA export from nucleus, embryonic organ development, stem cell development, embryonic placenta morphogenesis, transcription elongation from RNA polymerase II promoter, coronary vasculature morphogenesis, cell migration involved in vasculogenesis, morphogenesis of a branching structure, transcription, DNA-templated, mesoderm morphogenesis, vasculogenesis, histone H3-K36 methylation, methylation, neural tube closure, nucleosome organization, angiogenesis, pericardium development, regulation of gene expression, histone H3-K36 trimethylation, embryonic cranial skeleton morphogenesis, DNA mismatch repair, histone lysine methylation, forebrain development, regulation of double-strand break repair via homologous recombination, peptidyl-lysine trimethylation, peptidyl-lysine monomethylation, regulation of cytokinesis, positive regulation of interferon-alpha production, response to type I interferon, endodermal cell differentiation, stem cell differentiation, microtubule cytoskeleton organization involved in mitosis, regulation of protein localization to chromatin, immune system process, DNA repair, cellular response to DNA damage stimulus, multicellular organism development, cell differentiation, innate immune response, defense response to virus, chromatin organization

Cell component nucleoplasm, nucleus, chromosome

Encoded by SETD2

Found in taxon Homo sapiens

Has part(s) AWS domain, WW domain, SET domain, Set2 Rpb1 interacting domain, Post-SET domain

Imported from wholeness_audit_2026-05-02

Molecular function methyltransferase activity, transferase activity, protein binding, histone-lysine N-methyltransferase activity, protein-lysine N-methyltransferase activity, alpha-tubulin binding, histone methyltransferase activity (H3-K36 specific), metal ion binding

External References (6)

Ensembl protein id ENSP00000386759, ENSP00000332415, ENSP00000388349, ENSP00000411901, ENSP00000416401, ENSP00000491413

Mesh descriptor id C521636

Pdb structure id 2A7O, 2MDC, 2MDI, 2MDJ, 4FMU, 4H12

Refseq protein id NP_054878, XP_011531934, XP_011531936, NP_001336299, XP_024309255, XP_024309256, XP_024309257

Umls cui C1958958

Uniprot protein id Q9BYW2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SET domain containing 2, histone lysine methyltransferase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ SET domain containing 2, histone lysine methyltransferase — UniProt protein ID (P352): Q9BYW2. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): WW domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): TFIIS/LEDGF domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): Set2 Rpb1 interacting domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): Post-SET domain, protein family. wikidata.org.
[8] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): Set2 Rpb1 interacting domain, protein family. wikidata.org.
[9] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): SET domain, protein family. wikidata.org.
[10] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): WW domain, protein family. wikidata.org.
[11] ↑ SET domain containing 2, histone lysine methyltransferase — part of (P361): AWS domain, protein family. wikidata.org.
[12] ↑ SET domain containing 2, histone lysine methyltransferase — MeSH descriptor ID (P486): C521636. wikidata.org.
[13] ↑ SET domain containing 2, histone lysine methyltransferase — has part(s) (P527): AWS domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ SET domain containing 2, histone lysine methyltransferase — has part(s) (P527): WW domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ SET domain containing 2, histone lysine methyltransferase — has part(s) (P527): SET domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ SET domain containing 2, histone lysine methyltransferase — has part(s) (P527): Set2 Rpb1 interacting domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ SET domain containing 2, histone lysine methyltransferase — has part(s) (P527): Post-SET domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): NP_054878. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): XP_011531934. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): XP_011531936. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): NP_001336299. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): XP_024309255. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): XP_024309256. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ SET domain containing 2, histone lysine methyltransferase — RefSeq protein ID (P637): XP_024309257. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ SET domain containing 2, histone lysine methyltransferase — PDB structure ID (P638): 2A7O. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ SET domain containing 2, histone lysine methyltransferase — PDB structure ID (P638): 2MDC. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ SET domain containing 2, histone lysine methyltransferase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). SET domain containing 2, histone lysine methyltransferase. Retrieved May 3, 2026, from https://4ort.xyz/entity/set-domain-containing-2-histone-lysine-methyltransferase

MLA

“SET domain containing 2, histone lysine methyltransferase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/set-domain-containing-2-histone-lysine-methyltransferase.

BibTeX

@misc{4ortxyz_set-domain-containing-2-histone-lysine-methyltransferase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SET domain containing 2, histone lysine methyltransferase}}, year = {2026}, url = {https://4ort.xyz/entity/set-domain-containing-2-histone-lysine-methyltransferase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SET domain containing 2, histone lysine methyltransferase — https://4ort.xyz/entity/set-domain-containing-2-histone-lysine-methyltransferase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/set-domain-containing-2-histone-lysine-methyltransferase · Last refreshed: May 3, 2026