sclerostin

mammalian protein found in Homo sapiens
Protein protein Q7434196
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sclerostin

Summary

sclerostin is a protein[1].

Key Facts

  • sclerostin's instance of is recorded as protein[2].
  • sclerostin is part of Cystine-knot cytokine[3].
  • sclerostin is part of Sclerostin[4].
  • sclerostin is part of Cystine knot, C-terminal domain, protein family[5].
  • sclerostin comprises Cystine knot, C-terminal[6].
  • sclerostin's molecular function is recorded as transcription factor binding[7].
  • sclerostin's molecular function is recorded as protein binding[8].
  • sclerostin's molecular function is recorded as heparin binding[9].
  • sclerostin's cell component is recorded as extracellular matrix[10].
  • sclerostin's cell component is recorded as Golgi apparatus[11].
  • sclerostin's cell component is recorded as extracellular region[12].
  • sclerostin's cell component is recorded as extracellular space[13].
  • sclerostin's cell component is recorded as protein-containing complex[14].
  • sclerostin's cell component is recorded as collagen-containing extracellular matrix[15].
  • sclerostin's biological process is recorded as Wnt signaling pathway[16].
  • sclerostin's biological process is recorded as negative regulation of BMP signaling pathway[17].
  • sclerostin's biological process is recorded as positive regulation of transcription, DNA-templated[18].
  • sclerostin's biological process is recorded as response to mechanical stimulus[19].
  • sclerostin's biological process is recorded as negative regulation of protein-containing complex assembly[20].
  • sclerostin's biological process is recorded as negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification[21].
  • sclerostin's biological process is recorded as cellular response to parathyroid hormone stimulus[22].
  • sclerostin's biological process is recorded as ossification[23].
  • sclerostin's biological process is recorded as negative regulation of ossification[24].
  • sclerostin's biological process is recorded as negative regulation of canonical Wnt signaling pathway[25].
  • sclerostin's encoded by is recorded as SOST[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . Q905695. Retrieved . wikidata.org.
  2. [3] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] . wikidata.org.
  5. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] . Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] . Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] . Proteomics characterization of extracellular space components in the human aorta. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] . Proteomics characterization of extracellular space components in the human aorta. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] . Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] . Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . Q905695. Retrieved . wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). sclerostin. Retrieved May 3, 2026, from https://4ort.xyz/entity/sclerostin-q7434196
MLA “sclerostin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sclerostin-q7434196.
BibTeX @misc{4ortxyz_sclerostin-q7434196_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{sclerostin}}, year = {2026}, url = {https://4ort.xyz/entity/sclerostin-q7434196}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): sclerostin — https://4ort.xyz/entity/sclerostin-q7434196 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 9w ago · MatSuBot bot · 2026-06-29 view diff on Wikidata ↗
    Has part(s) Cystine knot, C-terminal
    Encoded by SOST
    Molecular function transcription factor binding, protein binding, heparin binding
    Imported from
    + 13 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update-languages-short:0||zh, it, fa, ar, pt, ca */ import labels from sitelinks"
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