Raf-1 proto-oncogene, serine/threonine kinase

mammalian protein found in Rattus norvegicus

Protein protein Q28558646

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Raf-1 proto-oncogene, serine/threonine kinase

Summary

Raf-1 proto-oncogene, serine/threonine kinase is a protein^[1].

Key Facts

Raf-1 proto-oncogene, serine/threonine kinase's instance of is recorded as protein^[2].
Raf-1 proto-oncogene, serine/threonine kinase's UniProt protein ID is recorded as P11345^[3].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Ubiquitin-like domain superfamily^[4].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Protein kinase-like domain superfamily^[5].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as membrane protein^[6].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[7].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family^[8].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Diacylglycerol/phorbol-ester binding domain, protein family^[9].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Raf-like Ras-binding domain, protein family^[10].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Protein kinase domain, protein family^[11].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Protein kinase, ATP binding site, protein family^[12].
Raf-1 proto-oncogene, serine/threonine kinase's part of is recorded as Serine/threonine-protein kinase, active site, protein family^[13].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as serine/threonine-protein kinase, active site^[14].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as protein kinase, ATP binding site^[15].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[16].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as diacylglycerol/phorbol-ester binding^[17].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as protein kinase domain^[18].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as protein kinase C-like, phorbol ester/diacylglycerol-binding domain^[19].
Raf-1 proto-oncogene, serine/threonine kinase's has part is recorded as Raf-like Ras-binding^[20].
Raf-1 proto-oncogene, serine/threonine kinase's RefSeq protein ID is recorded as NP_036771^[21].
Raf-1 proto-oncogene, serine/threonine kinase's RefSeq protein ID is recorded as XP_008761439^[22].
Raf-1 proto-oncogene, serine/threonine kinase's RefSeq protein ID is recorded as XP_008761440^[23].
Raf-1 proto-oncogene, serine/threonine kinase's RefSeq protein ID is recorded as XP_038962984^[24].
Raf-1 proto-oncogene, serine/threonine kinase's RefSeq protein ID is recorded as XP_038962985^[25].
Raf-1 proto-oncogene, serine/threonine kinase's molecular function is recorded as nucleotide binding^[26].

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Quick Facts

Instance of protein

Part of Ubiquitin-like domain superfamily, Protein kinase-like domain superfamily, membrane protein, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family, Diacylglycerol/phorbol-ester binding domain, protein family, Raf-like Ras-binding domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process MAPK cascade, response to hypoxia, cellular glucose homeostasis, positive regulation of protein phosphorylation, protein phosphorylation, signal transduction, activation of adenylate cyclase activity, development of the heart, negative regulation of cell population proliferation, phosphorylation, cell differentiation, thyroid gland development, negative regulation of protein-containing complex assembly, positive regulation of peptidyl-serine phosphorylation, somatic stem cell population maintenance, intracellular signal transduction, insulin secretion involved in cellular response to glucose stimulus, response to muscle stretch, negative regulation of apoptotic process, intermediate filament cytoskeleton organization, positive regulation of transcription by RNA polymerase II, neurotrophin TRK receptor signaling pathway, thymus development, face development, death-inducing signaling complex assembly, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cell component nucleus, cytoplasm, mitochondrion, Golgi apparatus, cytosol, plasma membrane, membrane, nuclear speck, pseudopodium

Encoded by Raf1

Found in taxon brown rat

Has part(s) serine/threonine-protein kinase, active site, protein kinase, ATP binding site, serine-threonine/tyrosine-protein kinase, catalytic domain, diacylglycerol/phorbol-ester binding, protein kinase domain, protein kinase C-like, phorbol ester/diacylglycerol-binding domain, Raf-like Ras-binding

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, MAP kinase kinase kinase activity, protein binding, ATP binding, adenylate cyclase binding, adenylate cyclase activator activity, kinase activity, transferase activity, enzyme binding, mitogen-activated protein kinase kinase binding, identical protein binding, metal ion binding, protein heterodimerization activity

External References (3)

Ensembl protein id ENSRNOP00000013831

Refseq protein id NP_036771, XP_008761439, XP_008761440, XP_038962984, XP_038962985

Uniprot protein id P11345

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Raf-1 proto-oncogene, serine/threonine kinase — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ Raf-1 proto-oncogene, serine/threonine kinase — UniProt protein ID (P352): P11345. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Ubiquitin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): membrane protein. wikidata.org.
[7] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[8] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family. wikidata.org.
[9] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Diacylglycerol/phorbol-ester binding domain, protein family. wikidata.org.
[10] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Raf-like Ras-binding domain, protein family. wikidata.org.
[11] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[12] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[13] ↑ Raf-1 proto-oncogene, serine/threonine kinase — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[14] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): diacylglycerol/phorbol-ester binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): protein kinase C-like, phorbol ester/diacylglycerol-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Raf-1 proto-oncogene, serine/threonine kinase — has part(s) (P527): Raf-like Ras-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Raf-1 proto-oncogene, serine/threonine kinase — RefSeq protein ID (P637): NP_036771. Q20641742. Retrieved 2021-09-07. wikidata.org.
[22] ↑ Raf-1 proto-oncogene, serine/threonine kinase — RefSeq protein ID (P637): XP_008761439. Q20641742. Retrieved 2021-09-07. wikidata.org.
[23] ↑ Raf-1 proto-oncogene, serine/threonine kinase — RefSeq protein ID (P637): XP_008761440. Q20641742. Retrieved 2021-09-07. wikidata.org.
[24] ↑ Raf-1 proto-oncogene, serine/threonine kinase — RefSeq protein ID (P637): XP_038962984. Q20641742. Retrieved 2021-09-07. wikidata.org.
[25] ↑ Raf-1 proto-oncogene, serine/threonine kinase — RefSeq protein ID (P637): XP_038962985. Q20641742. Retrieved 2021-09-07. wikidata.org.
[26] ↑ Raf-1 proto-oncogene, serine/threonine kinase — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Raf-1 proto-oncogene, serine/threonine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Raf-1 proto-oncogene, serine/threonine kinase. Retrieved May 3, 2026, from https://4ort.xyz/entity/raf-1-proto-oncogene-serine-threonine-kinase-q28558646

MLA

“Raf-1 proto-oncogene, serine/threonine kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/raf-1-proto-oncogene-serine-threonine-kinase-q28558646.

BibTeX

@misc{4ortxyz_raf-1-proto-oncogene-serine-threonine-kinase-q28558646_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Raf-1 proto-oncogene, serine/threonine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/raf-1-proto-oncogene-serine-threonine-kinase-q28558646}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Raf-1 proto-oncogene, serine/threonine kinase — https://4ort.xyz/entity/raf-1-proto-oncogene-serine-threonine-kinase-q28558646 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/raf-1-proto-oncogene-serine-threonine-kinase-q28558646 · Last refreshed: May 3, 2026