Promyelocytic leukemia

mammalian protein found in Mus musculus

Protein protein Q21990910

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Promyelocytic leukemia

Summary

Promyelocytic leukemia is a protein^[1].

Key Facts

Promyelocytic leukemia's instance of is recorded as protein^[2].
Promyelocytic leukemia's UniProt protein ID is recorded as Lilli Palmer^[3].
Promyelocytic leukemia's part of is recorded as Zinc finger, RING/FYVE/PHD-type^[4].
Promyelocytic leukemia's part of is recorded as Protein of unknown function DUF3583^[5].
Promyelocytic leukemia's part of is recorded as membrane protein^[6].
Promyelocytic leukemia's part of is recorded as B-box-type zinc finger, protein family^[7].
Promyelocytic leukemia's part of is recorded as Zinc finger, RING-type, protein family^[8].
Promyelocytic leukemia's part of is recorded as Zinc finger, RING-type, conserved site, protein family^[9].
Promyelocytic leukemia's has part is recorded as Zinc finger, RING-type^[10].
Promyelocytic leukemia's has part is recorded as B-box-type zinc finger^[11].
Promyelocytic leukemia's has part is recorded as Zinc finger, RING-type, conserved site^[12].
Promyelocytic leukemia's RefSeq protein ID is recorded as NP_001298017^[13].
Promyelocytic leukemia's RefSeq protein ID is recorded as NP_032910^[14].
Promyelocytic leukemia's RefSeq protein ID is recorded as NP_835188^[15].
Promyelocytic leukemia's RefSeq protein ID is recorded as XP_006510923^[16].
Promyelocytic leukemia's RefSeq protein ID is recorded as XP_006510924^[17].
Promyelocytic leukemia's RefSeq protein ID is recorded as XP_006510925^[18].
Promyelocytic leukemia's RefSeq protein ID is recorded as XP_006510927^[19].
Promyelocytic leukemia's RefSeq protein ID is recorded as XP_017168701^[20].
Promyelocytic leukemia's RefSeq protein ID is recorded as XP_030099988^[21].
Promyelocytic leukemia's molecular function is recorded as SUMO binding^[22].
Promyelocytic leukemia's molecular function is recorded as metal ion binding^[23].
Promyelocytic leukemia's molecular function is recorded as protein homodimerization activity^[24].
Promyelocytic leukemia's molecular function is recorded as protein binding^[25].
Promyelocytic leukemia's molecular function is recorded as SMAD binding^[26].

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Quick Facts

Instance of protein

Part of Zinc finger, RING/FYVE/PHD-type, Protein of unknown function DUF3583, membrane protein, B-box-type zinc finger, protein family, Zinc finger, RING-type, protein family, Zinc finger, RING-type, conserved site, protein family

Properties

Biological process regulation of protein phosphorylation, intrinsic apoptotic signaling pathway in response to oxidative stress, myeloid cell differentiation, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, rhythmic process, cellular senescence, regulation of cell adhesion, defense response to virus, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of MHC class I biosynthetic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, transforming growth factor beta receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of cell population proliferation, response to cytokine, cell fate commitment, regulation of transcription, DNA-templated, common-partner SMAD protein phosphorylation, branching involved in mammary gland duct morphogenesis, extrinsic apoptotic signaling pathway, positive regulation of fibroblast proliferation, positive regulation of apoptotic signaling pathway, endoplasmic reticulum calcium ion homeostasis, transcription, DNA-templated, PML body organization, negative regulation of cell growth, intrinsic apoptotic signaling pathway by p53 class mediator, innate immune response, viral process, response to gamma radiation, response to UV, regulation of calcium ion transport into cytosol, fibroblast migration, immune system process, circadian regulation of gene expression, regulation of MHC class I biosynthetic process, regulation of circadian rhythm, negative regulation of transcription, DNA-templated, maintenance of protein location in nucleus, cellular response to interleukin-4, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, response to hypoxia, regulation of double-strand break repair, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, retinoic acid receptor signaling pathway, negative regulation of angiogenesis, negative regulation of ubiquitin-dependent protein catabolic process, entrainment of circadian clock by photoperiod, positive regulation of transcription by RNA polymerase II, positive regulation of telomere maintenance, positive regulation of defense response to virus by host, protein targeting, apoptotic process, intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of histone deacetylation, negative regulation of telomere maintenance via telomerase, negative regulation of translation in response to oxidative stress, negative regulation of mitotic cell cycle, protein stabilization, negative regulation of telomerase activity, positive regulation of apoptotic process involved in mammary gland involution, positive regulation of protein localization to chromosome, telomeric region, cellular response to leukemia inhibitory factor, protein import into nucleus, protein-containing complex assembly, protein sumoylation, regulation of transcription, DNA-templated, intrinsic apoptotic signaling pathway in response to DNA damage, PML body organization, innate immune response, positive regulation of nucleic acid-templated transcription

Cell component cytoplasm, cytosol, endosome, membrane, nucleus, nucleolus, endoplasmic reticulum, early endosome membrane, intracellular anatomical structure, nucleoplasm, PML body, endoplasmic reticulum membrane, extrinsic component of endoplasmic reticulum membrane, nuclear matrix, heterochromatin, nuclear membrane, cytoplasm, nuclear matrix, PML body

Encoded by Pml

Found in taxon house mouse

Has part(s) Zinc finger, RING-type, B-box-type zinc finger, Zinc finger, RING-type, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function SUMO binding, metal ion binding, protein homodimerization activity, protein binding, SMAD binding, DNA binding, ubiquitin protein ligase binding, transcription coactivator activity, zinc ion binding, protein heterodimerization activity, cobalt ion binding, SUMO transferase activity, transcription coactivator activity, SUMO binding, SMAD binding

External References (3)

Ensembl protein id ENSMUSP00000082816, ENSMUSP00000109771, ENSMUSP00000116787, ENSMUSP00000118232, ENSMUSP00000118955, ENSMUSP00000120620, ENSMUSP00000121330, ENSMUSP00000121380, ENSMUSP00000122854

Refseq protein id NP_001298017, NP_032910, NP_835188, XP_006510923, XP_006510924, XP_006510925, XP_006510927, XP_017168701, XP_030099988

Uniprot protein id Lilli Palmer

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Promyelocytic leukemia — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Promyelocytic leukemia — UniProt protein ID (P352): Lilli Palmer. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Promyelocytic leukemia — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Promyelocytic leukemia — part of (P361): Protein of unknown function DUF3583. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Promyelocytic leukemia — part of (P361): membrane protein. wikidata.org.
[7] ↑ Promyelocytic leukemia — part of (P361): B-box-type zinc finger, protein family. wikidata.org.
[8] ↑ Promyelocytic leukemia — part of (P361): Zinc finger, RING-type, protein family. wikidata.org.
[9] ↑ Promyelocytic leukemia — part of (P361): Zinc finger, RING-type, conserved site, protein family. wikidata.org.
[10] ↑ Promyelocytic leukemia — has part(s) (P527): Zinc finger, RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Promyelocytic leukemia — has part(s) (P527): B-box-type zinc finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Promyelocytic leukemia — has part(s) (P527): Zinc finger, RING-type, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): NP_001298017. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): NP_032910. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): NP_835188. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): XP_006510923. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): XP_006510924. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): XP_006510925. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): XP_006510927. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): XP_017168701. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Promyelocytic leukemia — RefSeq protein ID (P637): XP_030099988. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Promyelocytic leukemia — molecular function (P680): SUMO binding. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Promyelocytic leukemia — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Promyelocytic leukemia — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Promyelocytic leukemia — molecular function (P680): protein binding. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Promyelocytic leukemia — molecular function (P680): SMAD binding. Cytoplasmic PML function in TGF-beta signalling. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Promyelocytic leukemia is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Promyelocytic leukemia. Retrieved May 3, 2026, from https://4ort.xyz/entity/promyelocytic-leukemia

MLA

“Promyelocytic leukemia.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/promyelocytic-leukemia.

BibTeX

@misc{4ortxyz_promyelocytic-leukemia_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Promyelocytic leukemia}}, year = {2026}, url = {https://4ort.xyz/entity/promyelocytic-leukemia}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Promyelocytic leukemia — https://4ort.xyz/entity/promyelocytic-leukemia (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/promyelocytic-leukemia · Last refreshed: May 3, 2026