Prion protein

mammalian protein found in Rattus norvegicus

Protein protein Q28556940

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Prion protein

Summary

Prion protein is a protein^[1].

Key Facts

Prion protein's instance of is recorded as protein^[2].
Prion protein's UniProt protein ID is recorded as P13852^[3].
Prion protein's part of is recorded as prion protein family^[4].
Prion protein's part of is recorded as Prion/Doppel beta-ribbon domain superfamily^[5].
Prion protein's part of is recorded as membrane protein^[6].
Prion protein's part of is recorded as Prion/Doppel protein, beta-ribbon domain, protein family^[7].
Prion protein's part of is recorded as Major prion protein N-terminal domain, protein family^[8].
Prion protein's has part is recorded as Major prion protein N-terminal domain^[9].
Prion protein's has part is recorded as Prion/Doppel protein, beta-ribbon domain^[10].
Prion protein's RefSeq protein ID is recorded as NP_036763^[11].
Prion protein's RefSeq protein ID is recorded as XP_006235124^[12].
Prion protein's RefSeq protein ID is recorded as XP_038960208^[13].
Prion protein's RefSeq protein ID is recorded as NP_001382587^[14].
Prion protein's molecular function is recorded as amyloid-beta binding^[15].
Prion protein's molecular function is recorded as protease binding^[16].
Prion protein's molecular function is recorded as copper ion binding^[17].
Prion protein's molecular function is recorded as protein binding^[18].
Prion protein's molecular function is recorded as lamin binding^[19].
Prion protein's molecular function is recorded as glycosaminoglycan binding^[20].
Prion protein's molecular function is recorded as microtubule binding^[21].
Prion protein's molecular function is recorded as tubulin binding^[22].
Prion protein's molecular function is recorded as type 5 metabotropic glutamate receptor binding^[23].
Prion protein's molecular function is recorded as signaling receptor activity^[24].
Prion protein's molecular function is recorded as identical protein binding^[25].
Prion protein's molecular function is recorded as ATP-dependent protein binding^[26].

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Quick Facts

Instance of protein

Part of prion protein family, Prion/Doppel beta-ribbon domain superfamily, membrane protein, Prion/Doppel protein, beta-ribbon domain, protein family, Major prion protein N-terminal domain, protein family

Properties

Biological process negative regulation of protein phosphorylation, response to oxidative stress, learning or memory, positive regulation of cell death, protein destabilization, activation of protein kinase activity, negative regulation of interferon-gamma production, negative regulation of interleukin-17 production, negative regulation of interleukin-2 production, regulation of protein localization, calcium-mediated signaling using intracellular calcium source, negative regulation of apoptotic process, negative regulation of catalytic activity, negative regulation of DNA-binding transcription factor activity, positive regulation of neuron apoptotic process, negative regulation of activated T cell proliferation, response to cadmium ion, response to copper ion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of T cell receptor signaling pathway, protein homooligomerization, positive regulation of protein tyrosine kinase activity, negative regulation of calcineurin-NFAT signaling cascade, cellular response to copper ion, positive regulation of protein targeting to membrane, negative regulation of long-term synaptic potentiation, regulation of glutamate receptor signaling pathway, positive regulation of neuron death, regulation of potassium ion transmembrane transport, negative regulation of amyloid-beta formation, regulation of intracellular calcium activated chloride channel activity, negative regulation of dendritic spine maintenance, negative regulation of amyloid precursor protein catabolic process, positive regulation of protein localization to plasma membrane, response to amyloid-beta, cellular response to amyloid-beta, regulation of calcium ion import across plasma membrane, neuron projection maintenance

Cell component cytoplasm, endoplasmic reticulum, Golgi apparatus, cytosol, plasma membrane, cell surface, postsynaptic density, membrane, inclusion body, dendrite, anchored component of membrane, nuclear membrane, intracellular membrane-bounded organelle, membrane raft, anchored component of plasma membrane

Encoded by Prnp

Found in taxon brown rat

Has part(s) Major prion protein N-terminal domain, Prion/Doppel protein, beta-ribbon domain

Imported from wholeness_audit_2026-05-02

Molecular function amyloid-beta binding, protease binding, copper ion binding, protein binding, lamin binding, glycosaminoglycan binding, microtubule binding, tubulin binding, type 5 metabotropic glutamate receptor binding, signaling receptor activity, identical protein binding, ATP-dependent protein binding, transmembrane transporter binding, protein-containing complex binding, metal ion binding, chaperone binding, cupric ion binding, cuprous ion binding

External References (3)

Ensembl protein id ENSRNOP00000028881

Refseq protein id NP_036763, XP_006235124, XP_038960208, NP_001382587

Uniprot protein id P13852

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Prion protein — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ Prion protein — UniProt protein ID (P352): P13852. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ Prion protein — part of (P361): prion protein family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Prion protein — part of (P361): Prion/Doppel beta-ribbon domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Prion protein — part of (P361): membrane protein. wikidata.org.
[7] ↑ Prion protein — part of (P361): Prion/Doppel protein, beta-ribbon domain, protein family. wikidata.org.
[8] ↑ Prion protein — part of (P361): Major prion protein N-terminal domain, protein family. wikidata.org.
[9] ↑ Prion protein — has part(s) (P527): Major prion protein N-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Prion protein — has part(s) (P527): Prion/Doppel protein, beta-ribbon domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Prion protein — RefSeq protein ID (P637): NP_036763. Q20641742. Retrieved 2021-09-07. wikidata.org.
[12] ↑ Prion protein — RefSeq protein ID (P637): XP_006235124. Q20641742. Retrieved 2021-09-07. wikidata.org.
[13] ↑ Prion protein — RefSeq protein ID (P637): XP_038960208. Q20641742. Retrieved 2021-09-07. wikidata.org.
[14] ↑ Prion protein — RefSeq protein ID (P637): NP_001382587. Q20641742. Retrieved 2021-09-07. wikidata.org.
[15] ↑ Prion protein — molecular function (P680): amyloid-beta binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Prion protein — molecular function (P680): protease binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Prion protein — molecular function (P680): copper ion binding. Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Prion protein — molecular function (P680): protein binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Prion protein — molecular function (P680): lamin binding. Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Prion protein — molecular function (P680): glycosaminoglycan binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Prion protein — molecular function (P680): microtubule binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Prion protein — molecular function (P680): tubulin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Prion protein — molecular function (P680): type 5 metabotropic glutamate receptor binding. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Prion protein — molecular function (P680): signaling receptor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Prion protein — molecular function (P680): identical protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Prion protein — molecular function (P680): ATP-dependent protein binding. Rdj2, a J protein family member, interacts with cellular prion PrP(C). Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Prion protein is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Prion protein. Retrieved May 3, 2026, from https://4ort.xyz/entity/prion-protein

MLA “Prion protein.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/prion-protein.

BibTeX

@misc{4ortxyz_prion-protein_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Prion protein}}, year = {2026}, url = {https://4ort.xyz/entity/prion-protein}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Prion protein — https://4ort.xyz/entity/prion-protein (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/prion-protein · Last refreshed: May 3, 2026