Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

mammalian protein found in Homo sapiens

Protein protein Q7117823

Press Enter · cited answer in seconds

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Summary

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is a protein^[1].

Key Facts

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's instance of is recorded as protein^[2].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's physically interacts with is recorded as dactolisib^[3].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's physically interacts with is recorded as idelalisib^[4].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's physically interacts with is recorded as LY-294002^[5].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3-kinase, Vps34 type^[6].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Ubiquitin-like domain superfamily^[7].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Protein kinase-like domain superfamily^[8].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily^[9].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol kinase family^[10].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Armadillo-type fold^[11].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family^[12].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3-kinase, C2 domain, protein family^[13].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family^[14].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of PI3Kalpha, catalytic domain, protein family^[15].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family^[16].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphoinositide 3-kinase, accessory (PIK) domain, protein family^[17].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is part of Phosphatidylinositol 3/4-kinase, conserved site, protein family^[18].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain^[19].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain^[20].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises Phosphoinositide 3-kinase, accessory (PIK) domain^[21].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises Phosphatidylinositol 3/4-kinase, conserved site^[22].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises Phosphatidylinositol 3-kinase, C2 domain^[23].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises Phosphatidylinositol 3-/4-kinase, catalytic domain^[24].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha comprises PI3Kalpha, catalytic domain^[25].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's EC enzyme number is recorded as 2.7.11.1^[26].

⭐ Popularity Graph

0/100 long tail

Quick Facts

Instance of protein

Part of Phosphatidylinositol 3-kinase, Vps34 type, Ubiquitin-like domain superfamily, Protein kinase-like domain superfamily, Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily, Phosphatidylinositol kinase family, Armadillo-type fold, Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family, Phosphatidylinositol 3-kinase, C2 domain, protein family, Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family, PI3Kalpha, catalytic domain, protein family, Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family, Phosphoinositide 3-kinase, accessory (PIK) domain, protein family, Phosphatidylinositol 3/4-kinase, conserved site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, cardiac muscle contraction, epidermal growth factor receptor signaling pathway, protein kinase B signaling, Fc-gamma receptor signaling pathway involved in phagocytosis, regulation of multicellular organism growth, T cell costimulation, hypomethylation of CpG island, positive regulation of peptidyl-serine phosphorylation, platelet activation, Fc-epsilon receptor signaling pathway, phosphatidylinositol phosphate biosynthetic process, vascular endothelial growth factor receptor signaling pathway, vasculature development, angiogenesis, insulin receptor signaling pathway via phosphatidylinositol 3-kinase, glucose metabolic process, phagocytosis, energy homeostasis, negative regulation of fibroblast apoptotic process, regulation of gene expression, liver development, adipose tissue development, regulation of cellular respiration, T cell receptor signaling pathway, activation of protein kinase activity, regulation of genetic imprinting, negative regulation of anoikis, cellular response to glucose stimulus, endothelial cell migration, phosphatidylinositol-mediated signaling, leukocyte migration, ERBB2 signaling pathway, phosphatidylinositol-3-phosphate biosynthetic process, axon guidance, negative regulation of macroautophagy, phosphorylation, positive regulation of TOR signaling, anoikis, adaptive immune response, protein phosphorylation, inflammatory response, innate immune response, cell chemotaxis, G protein-coupled receptor signaling pathway, positive regulation of protein kinase B signaling, phosphatidylinositol 3-kinase signaling, cytokine-mediated signaling pathway, cell migration, platelet activation, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of phosphatidylinositol 3-kinase signaling, phosphatidylinositol biosynthetic process, regulation of protein phosphorylation, protein phosphorylation, protein phosphorylation

Cell component phosphatidylinositol 3-kinase complex, cytosol, phosphatidylinositol 3-kinase complex, class IA, plasma membrane, lamellipodium, cytoplasm, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, membrane

Ec enzyme number 2.7.11.1, 2.7.1.137

Encoded by PIK3CA

Found in taxon Homo sapiens

Has part(s) Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, Phosphoinositide 3-kinase, accessory (PIK) domain, Phosphatidylinositol 3/4-kinase, conserved site, Phosphatidylinositol 3-kinase, C2 domain, Phosphatidylinositol 3-/4-kinase, catalytic domain, PI3Kalpha, catalytic domain

Molecular function transferase activity, nucleotide binding, protein kinase activator activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, protein serine/threonine kinase activity, protein binding, insulin receptor substrate binding, ATP binding, 1-phosphatidylinositol-3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, kinase activity, phosphatidylinositol 3-kinase activity, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity

Physically interacts with dactolisib, idelalisib, LY-294002

External References (6)

Ensembl protein id ENSP00000263967, ENSP00000417479, ENSP00000418145, ENSP00000493507

Mesh descriptor id C484760

Pdb structure id 2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP

Refseq protein id NP_006209, XP_006713721, XP_011511196

Umls cui C1451005

Uniprot protein id P42336

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — physically interacts with (P129): dactolisib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — physically interacts with (P129): idelalisib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — physically interacts with (P129): LY-294002. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase, Vps34 type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Ubiquitin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol kinase family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Armadillo-type fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family. wikidata.org.
[13] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase, C2 domain, protein family. wikidata.org.
[14] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family. wikidata.org.
[15] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): PI3Kalpha, catalytic domain, protein family. wikidata.org.
[16] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family. wikidata.org.
[17] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphoinositide 3-kinase, accessory (PIK) domain, protein family. wikidata.org.
[18] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3/4-kinase, conserved site, protein family. wikidata.org.
[19] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphoinositide 3-kinase, accessory (PIK) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3/4-kinase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-kinase, C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-/4-kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): PI3Kalpha, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — EC enzyme number (P591): 2.7.11.1. Q905695. Retrieved 2015-10-12. uniprot.org. Provenance: wikidata.org.

Class ancestry

[1] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. Retrieved May 3, 2026, from https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823

MLA

“Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823.

BibTeX

@misc{4ortxyz_phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha}}, year = {2026}, url = {https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

10d ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P42336

Umls cui → C1451005

Imported from → —

Mesh descriptor id → C484760

+ 15 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.1.137, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.