Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

mammalian protein found in Mus musculus

Protein protein Q14887711

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Summary

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is a protein^[1].

Key Facts

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's instance of is recorded as protein^[2].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's UniProt protein ID is recorded as P42337^[3].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3-kinase, Vps34 type^[4].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Ubiquitin-like domain superfamily^[5].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Protein kinase-like domain superfamily^[6].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily^[7].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol kinase family^[8].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Armadillo-type fold^[9].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as membrane protein^[10].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family^[11].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3-kinase, C2 domain, protein family^[12].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family^[13].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as PI3Kalpha, catalytic domain, protein family^[14].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family^[15].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphoinositide 3-kinase, accessory (PIK) domain, protein family^[16].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's part of is recorded as Phosphatidylinositol 3/4-kinase, conserved site, protein family^[17].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as Phosphatidylinositol 3-kinase, C2 domain^[18].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as Phosphoinositide 3-kinase, accessory (PIK) domain^[19].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain^[20].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as Phosphatidylinositol 3-/4-kinase, catalytic domain^[21].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as Phosphatidylinositol 3/4-kinase, conserved site^[22].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain^[23].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's has part is recorded as PI3Kalpha, catalytic domain^[24].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's RefSeq protein ID is recorded as NP_032865^[25].
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha's PDB structure ID is recorded as 4A55^[26].

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Quick Facts

Instance of protein

Part of Phosphatidylinositol 3-kinase, Vps34 type, Ubiquitin-like domain superfamily, Protein kinase-like domain superfamily, Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily, Phosphatidylinositol kinase family, Armadillo-type fold, membrane protein, Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family, Phosphatidylinositol 3-kinase, C2 domain, protein family, Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family, PI3Kalpha, catalytic domain, protein family, Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family, Phosphoinositide 3-kinase, accessory (PIK) domain, protein family, Phosphatidylinositol 3/4-kinase, conserved site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, protein kinase B signaling, regulation of multicellular organism growth, hypomethylation of CpG island, positive regulation of peptidyl-serine phosphorylation, protein phosphorylation, angiogenesis, glucose metabolic process, phagocytosis, energy homeostasis, regulation of gene expression, negative regulation of fibroblast apoptotic process, liver development, adipose tissue development, regulation of cellular respiration, negative regulation of anoikis, regulation of genetic imprinting, cellular response to glucose stimulus, phosphatidylinositol-mediated signaling, phosphatidylinositol-3-phosphate biosynthetic process, activation of protein kinase activity, phosphorylation, adaptive immune response, inflammatory response, platelet activation, innate immune response, cell chemotaxis, phosphatidylinositol 3-kinase signaling, phosphatidylinositol phosphate biosynthetic process, positive regulation of smooth muscle cell proliferation, negative regulation of gene expression, protein phosphorylation, cell migration, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-mediated signaling, regulation of protein phosphorylation, protein phosphorylation, protein phosphorylation

Cell component plasma membrane, lamellipodium, cytoplasm, phosphatidylinositol 3-kinase complex, class IA, cytosol, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, membrane

Encoded by Pik3ca

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon house mouse

Has part(s) Phosphatidylinositol 3-kinase, C2 domain, Phosphoinositide 3-kinase, accessory (PIK) domain, Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, Phosphatidylinositol 3-/4-kinase, catalytic domain, Phosphatidylinositol 3/4-kinase, conserved site, Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, PI3Kalpha, catalytic domain

Imported from wholeness_audit_2026-05-02

Molecular function transferase activity, nucleotide binding, 1-phosphatidylinositol-3-kinase activity, protein kinase activator activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, protein serine/threonine kinase activity, protein binding, insulin receptor substrate binding, ATP binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity

External References (4)

Ensembl protein id ENSMUSP00000029201, ENSMUSP00000103878, ENSMUSP00000103877

Pdb structure id 4A55

Refseq protein id NP_032865

Uniprot protein id P42337

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — UniProt protein ID (P352): P42337. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase, Vps34 type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Ubiquitin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol kinase family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Armadillo-type fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): membrane protein. wikidata.org.
[11] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family. wikidata.org.
[12] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase, C2 domain, protein family. wikidata.org.
[13] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family. wikidata.org.
[14] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): PI3Kalpha, catalytic domain, protein family. wikidata.org.
[15] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family. wikidata.org.
[16] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphoinositide 3-kinase, accessory (PIK) domain, protein family. wikidata.org.
[17] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — part of (P361): Phosphatidylinositol 3/4-kinase, conserved site, protein family. wikidata.org.
[18] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-kinase, C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphoinositide 3-kinase, accessory (PIK) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-/4-kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3/4-kinase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — has part(s) (P527): PI3Kalpha, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — RefSeq protein ID (P637): NP_032865. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — PDB structure ID (P638): 4A55. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. Retrieved May 3, 2026, from https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha

MLA

“Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha.

BibTeX

@misc{4ortxyz_phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha}}, year = {2026}, url = {https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha — https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha · Last refreshed: May 3, 2026