Parkin RBR E3 ubiquitin protein ligase

mammalian protein found in Rattus norvegicus

Protein protein Q28558502

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Parkin RBR E3 ubiquitin protein ligase

Summary

Parkin RBR E3 ubiquitin protein ligase is a protein^[1].

Key Facts

Parkin RBR E3 ubiquitin protein ligase's instance of is recorded as protein^[2].
Parkin RBR E3 ubiquitin protein ligase's UniProt protein ID is recorded as Q9JK66^[3].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as Ubiquitin-like domain superfamily^[4].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as E3 ubiquitin-protein ligase parkin^[5].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as membrane protein^[6].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as IBR domain, protein family^[7].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as Ubiquitin-like domain, protein family^[8].
Parkin RBR E3 ubiquitin protein ligase's has part is recorded as Ubiquitin domain^[9].
Parkin RBR E3 ubiquitin protein ligase's has part is recorded as IBR domain^[10].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_064478^[11].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944638^[12].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944640^[13].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944641^[14].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944642^[15].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944645^[16].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944646^[17].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944647^[18].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944651^[19].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944652^[20].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944653^[21].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_038944655^[22].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as transcription cis-regulatory region binding^[23].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as G protein-coupled receptor binding^[24].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin-protein transferase activity^[25].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Part of Ubiquitin-like domain superfamily, E3 ubiquitin-protein ligase parkin, membrane protein, IBR domain, protein family, Ubiquitin-like domain, protein family

Properties

Biological process protein polyubiquitination, mitochondrial fission, autophagy of mitochondrion, negative regulation of protein phosphorylation, ubiquitin-dependent protein catabolic process, protein monoubiquitination, autophagy, response to oxidative stress, response to unfolded protein, mitochondrion organization, brain development, adult locomotory behavior, regulation of gene expression, regulation of autophagy, positive regulation of mitochondrial fusion, negative regulation of mitochondrial fusion, regulation of mitochondrion organization, positive regulation of mitochondrial membrane potential, response to muscle activity, protein ubiquitination, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of glucokinase activity, response to endoplasmic reticulum stress, positive regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of apoptotic process, positive regulation of apoptotic process, positive regulation of I-kappaB kinase/NF-kappaB signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of DNA binding, negative regulation of neuron apoptotic process, mitochondrial fragmentation involved in apoptotic process, positive regulation of transcription by RNA polymerase II, negative regulation of JNK cascade, negative regulation of insulin secretion, response to corticosterone, mitochondrion localization, protein autoubiquitination, negative regulation of synaptic transmission, glutamatergic, zinc ion homeostasis, neuron cellular homeostasis, protein K63-linked ubiquitination, protein localization to mitochondrion, aggresome assembly, protein K48-linked ubiquitination, protein K11-linked ubiquitination, cellular response to manganese ion, protein K6-linked ubiquitination, positive regulation of mitochondrial fission, negative regulation of release of cytochrome c from mitochondria, negative regulation of mitochondrial fission, negative regulation of excitatory postsynaptic potential, cellular response to toxic substance, regulation of cellular response to oxidative stress, negative regulation of neuron death, positive regulation of mitophagy, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of oxidative stress-induced neuron death, positive regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of reactive oxygen species biosynthetic process, response to curcumin, cellular response to L-glutamine, cellular response to hydrogen sulfide, cellular response to L-glutamate, negative regulation of reactive oxygen species metabolic process, positive regulation of ATP biosynthetic process

Cell component Golgi membrane, ubiquitin ligase complex, nucleus, cytoplasm, mitochondrion, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, cytosol, plasma membrane, synaptic vesicle, postsynaptic density, membrane, aggresome, cell junction, axon, dendrite, synaptic vesicle membrane, cytoplasmic vesicle, cell projection, neuron projection, soma, terminal bouton, membrane raft, synapse, postsynaptic membrane, perinuclear region of cytoplasm, LUBAC complex, intracellular vesicle, presynapse, Parkin-FBXW7-Cul1 ubiquitin ligase complex

Encoded by Prkn

Found in taxon brown rat

Has part(s) Ubiquitin domain, IBR domain

Imported from wholeness_audit_2026-05-02

Molecular function transcription cis-regulatory region binding, G protein-coupled receptor binding, ubiquitin-protein transferase activity, protein binding, transferase activity, protein kinase binding, PDZ domain binding, ubiquitin conjugating enzyme binding, identical protein binding, ubiquitin binding, protein-containing complex binding, metal ion binding, ubiquitin protein ligase activity, cullin family protein binding, F-box domain binding

External References (3)

Ensembl protein id ENSRNOP00000077507, ENSRNOP00000072264, ENSRNOP00000086350, ENSRNOP00000071167, ENSRNOP00000088932, ENSRNOP00000070559, ENSRNOP00000075137, ENSRNOP00000091214, ENSRNOP00000079341, ENSRNOP00000074053

Refseq protein id NP_064478, XP_038944638, XP_038944640, XP_038944641, XP_038944642, XP_038944645, XP_038944646, XP_038944647, XP_038944651, XP_038944652, XP_038944653, XP_038944655

Uniprot protein id Q9JK66

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Parkin RBR E3 ubiquitin protein ligase — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Parkin RBR E3 ubiquitin protein ligase — UniProt protein ID (P352): Q9JK66. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): Ubiquitin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): E3 ubiquitin-protein ligase parkin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): membrane protein. wikidata.org.
[7] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): IBR domain, protein family. wikidata.org.
[8] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): Ubiquitin-like domain, protein family. wikidata.org.
[9] ↑ Parkin RBR E3 ubiquitin protein ligase — has part(s) (P527): Ubiquitin domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Parkin RBR E3 ubiquitin protein ligase — has part(s) (P527): IBR domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_064478. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944638. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944640. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944641. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944642. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944645. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944646. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944647. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944651. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944652. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944653. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_038944655. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): transcription cis-regulatory region binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): G protein-coupled receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): ubiquitin-protein transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): protein binding. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Parkin RBR E3 ubiquitin protein ligase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Parkin RBR E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q28558502

MLA

“Parkin RBR E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q28558502.

BibTeX

@misc{4ortxyz_parkin-rbr-e3-ubiquitin-protein-ligase-q28558502_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Parkin RBR E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q28558502}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Parkin RBR E3 ubiquitin protein ligase — https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q28558502 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q28558502 · Last refreshed: May 3, 2026