Parkin RBR E3 ubiquitin protein ligase

mammalian protein found in Mus musculus

Protein protein Q14864264

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Parkin RBR E3 ubiquitin protein ligase

Summary

Parkin RBR E3 ubiquitin protein ligase is a protein^[1].

Key Facts

Parkin RBR E3 ubiquitin protein ligase's instance of is recorded as protein^[2].
Parkin RBR E3 ubiquitin protein ligase's UniProt protein ID is recorded as Q9WVS6^[3].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as Ubiquitin-like domain superfamily^[4].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as E3 ubiquitin-protein ligase parkin^[5].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as membrane protein^[6].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as IBR domain, protein family^[7].
Parkin RBR E3 ubiquitin protein ligase's part of is recorded as Ubiquitin-like domain, protein family^[8].
Parkin RBR E3 ubiquitin protein ligase's has part is recorded as IBR domain^[9].
Parkin RBR E3 ubiquitin protein ligase's has part is recorded as Ubiquitin domain^[10].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001304655^[11].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_057903^[12].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_006523399^[13].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_006523400^[14].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_006523402^[15].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_017173061^[16].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_017173062^[17].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_017173063^[18].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_017173064^[19].
Parkin RBR E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_017173065^[20].
Parkin RBR E3 ubiquitin protein ligase's PDB structure ID is recorded as 1MG8^[21].
Parkin RBR E3 ubiquitin protein ligase's PDB structure ID is recorded as 2ZEQ^[22].
Parkin RBR E3 ubiquitin protein ligase's PDB structure ID is recorded as 3B1L^[23].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as phospholipase binding^[24].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as histone deacetylase binding^[25].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as tubulin binding^[26].

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Quick Facts

Instance of protein

Part of Ubiquitin-like domain superfamily, E3 ubiquitin-protein ligase parkin, membrane protein, IBR domain, protein family, Ubiquitin-like domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, negative regulation of insulin secretion, positive regulation of mitophagy in response to mitochondrial depolarization, positive regulation of mitochondrial fission, synaptic transmission, glutamatergic, positive regulation of tumor necrosis factor-mediated signaling pathway, neuron cellular homeostasis, regulation of protein ubiquitination, cellular response to toxic substance, modulation of chemical synaptic transmission, learning, protein monoubiquitination, synaptic transmission, dopaminergic, positive regulation of neurotransmitter uptake, protein K6-linked ubiquitination, negative regulation of spontaneous neurotransmitter secretion, positive regulation of DNA binding, negative regulation by host of viral genome replication, negative regulation of canonical Wnt signaling pathway, aggresome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of cellular response to oxidative stress, zinc ion homeostasis, free ubiquitin chain polymerization, regulation of transcription, DNA-templated, locomotory behavior, norepinephrine metabolic process, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, adult locomotory behavior, protein metabolic process, negative regulation of cell death, response to oxidative stress, negative regulation of gene expression, transcription, DNA-templated, response to endoplasmic reticulum stress, protein K11-linked ubiquitination, protein ubiquitination, positive regulation of mitochondrial fusion, proteasomal protein catabolic process, negative regulation of mitochondrial fusion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein autoubiquitination, negative regulation of neuron death, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of primary amine oxidase activity, startle response, mitochondrial fission, negative regulation of release of cytochrome c from mitochondria, protein stabilization, mitochondrion organization, regulation of neurotransmitter secretion, regulation of reactive oxygen species metabolic process, positive regulation of protein linear polyubiquitination, protein K48-linked ubiquitination, dopamine uptake involved in synaptic transmission, regulation of autophagy, protein destabilization, negative regulation of glucokinase activity, positive regulation of proteasomal protein catabolic process, protein K63-linked ubiquitination, negative regulation of actin filament bundle assembly, regulation of dopamine metabolic process, autophagy, regulation of mitochondrial membrane potential, negative regulation of JNK cascade, dopamine metabolic process, positive regulation of gene expression, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of dendrite extension, negative regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of transcription by RNA polymerase II, protein polyubiquitination, mitophagy, autophagy of mitochondrion, negative regulation of protein phosphorylation, regulation of mitochondrion organization, regulation of protein stability, positive regulation of protein binding, parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization, mitochondrion to lysosome transport, negative regulation of exosomal secretion, negative regulation of intralumenal vesicle formation, positive regulation of protein localization to membrane, positive regulation of autophagy of mitochondrion, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, ubiquitin-dependent protein catabolic process, response to unfolded protein, regulation of gene expression, positive regulation of mitochondrial membrane potential, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of apoptotic process, mitochondrial fragmentation involved in apoptotic process, mitochondrion localization, negative regulation of synaptic transmission, glutamatergic, protein localization to mitochondrion, negative regulation of mitochondrial fission, negative regulation of excitatory postsynaptic potential, positive regulation of mitophagy, negative regulation of oxidative stress-induced neuron death, negative regulation of reactive oxygen species biosynthetic process, cellular response to hydrogen sulfide, cellular response to L-glutamate, positive regulation of ATP biosynthetic process, protein polyubiquitination, autophagy of mitochondrion, negative regulation of protein phosphorylation, ubiquitin-dependent protein catabolic process, regulation of mitochondrion organization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of cellular response to oxidative stress, regulation of apoptotic process

Cell component cytoplasm, postsynaptic membrane, membrane, mitochondrion, perinuclear region of cytoplasm, nucleus, cell projection, aggresome, Parkin-FBXW7-Cul1 ubiquitin ligase complex, ubiquitin ligase complex, plasma membrane, LUBAC complex, cell junction, dendrite, endoplasmic reticulum, Golgi apparatus, cytosol, neuron projection, mitochondrion-derived vesicle, nuclear speck, protein-containing complex, Golgi membrane, intracellular anatomical structure, endoplasmic reticulum membrane, synaptic vesicle, postsynaptic density, axon, synaptic vesicle membrane, cytoplasmic vesicle, soma, terminal bouton, membrane raft, synapse, presynapse, cytoplasm, mitochondrion, endoplasmic reticulum, Golgi apparatus, cytosol, intracellular vesicle, LUBAC complex

Encoded by Prkn

Found in taxon house mouse

Has part(s) IBR domain, Ubiquitin domain

Imported from wholeness_audit_2026-05-02

Molecular function phospholipase binding, histone deacetylase binding, tubulin binding, cullin family protein binding, PDZ domain binding, heat shock protein binding, ubiquitin protein ligase activity, metal ion binding, Hsp70 protein binding, kinase binding, enzyme binding, beta-catenin binding, protein binding, ubiquitin conjugating enzyme binding, protein kinase binding, chaperone binding, ubiquitin-protein transferase activity, F-box domain binding, ubiquitin binding, identical protein binding, actin binding, ubiquitin-specific protease binding, G protein-coupled receptor binding, ubiquitin protein ligase binding, transcription cis-regulatory region binding, transferase activity, protein-containing complex binding, ubiquitin protein ligase activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein-containing complex binding

External References (4)

Ensembl protein id ENSMUSP00000140587, ENSMUSP00000127455, ENSMUSP00000136268, ENSMUSP00000140217, ENSMUSP00000151830

Pdb structure id 1MG8, 2ZEQ, 3B1L

Refseq protein id NP_001304655, NP_057903, XP_006523399, XP_006523400, XP_006523402, XP_017173061, XP_017173062, XP_017173063, XP_017173064, XP_017173065

Uniprot protein id Q9WVS6

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Parkin RBR E3 ubiquitin protein ligase — instance of (P31): protein. Q905695. Retrieved 2018-09-12. wikidata.org.
[3] ↑ Parkin RBR E3 ubiquitin protein ligase — UniProt protein ID (P352): Q9WVS6. Q905695. Retrieved 2018-09-12. wikidata.org.
[4] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): Ubiquitin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): E3 ubiquitin-protein ligase parkin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): membrane protein. wikidata.org.
[7] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): IBR domain, protein family. wikidata.org.
[8] ↑ Parkin RBR E3 ubiquitin protein ligase — part of (P361): Ubiquitin-like domain, protein family. wikidata.org.
[9] ↑ Parkin RBR E3 ubiquitin protein ligase — has part(s) (P527): IBR domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Parkin RBR E3 ubiquitin protein ligase — has part(s) (P527): Ubiquitin domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001304655. Q20641742. Retrieved 2018-09-14. wikidata.org.
[12] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_057903. Q20641742. Retrieved 2018-09-14. wikidata.org.
[13] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_006523399. Q20641742. Retrieved 2018-09-14. wikidata.org.
[14] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_006523400. Q20641742. Retrieved 2018-09-14. wikidata.org.
[15] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_006523402. Q20641742. Retrieved 2018-09-14. wikidata.org.
[16] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_017173061. Q20641742. Retrieved 2018-09-14. wikidata.org.
[17] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_017173062. Q20641742. Retrieved 2018-09-14. wikidata.org.
[18] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_017173063. Q20641742. Retrieved 2018-09-14. wikidata.org.
[19] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_017173064. Q20641742. Retrieved 2018-09-14. wikidata.org.
[20] ↑ Parkin RBR E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_017173065. Q20641742. Retrieved 2018-09-14. wikidata.org.
[21] ↑ Parkin RBR E3 ubiquitin protein ligase — PDB structure ID (P638): 1MG8. Q905695. Retrieved 2016-08-10. wikidata.org.
[22] ↑ Parkin RBR E3 ubiquitin protein ligase — PDB structure ID (P638): 2ZEQ. Q905695. Retrieved 2016-08-10. wikidata.org.
[23] ↑ Parkin RBR E3 ubiquitin protein ligase — PDB structure ID (P638): 3B1L. Q905695. Retrieved 2016-08-10. wikidata.org.
[24] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): phospholipase binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): histone deacetylase binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Parkin RBR E3 ubiquitin protein ligase — molecular function (P680): tubulin binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Parkin RBR E3 ubiquitin protein ligase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Parkin RBR E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264

MLA

“Parkin RBR E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264.

BibTeX

@misc{4ortxyz_parkin-rbr-e3-ubiquitin-protein-ligase-q14864264_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Parkin RBR E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Parkin RBR E3 ubiquitin protein ligase — https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264 · Last refreshed: May 3, 2026