Optineurin

mammalian protein found in Mus musculus

Protein protein Q21987802

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Optineurin

Summary

Optineurin is a protein^[1].

Key Facts

Optineurin's instance of is recorded as protein^[2].
Optineurin's subclass of is recorded as protein^[3].
Optineurin's UniProt protein ID is recorded as Q8K3K8^[4].
Optineurin's part of is recorded as Optineurin^[5].
Optineurin's part of is recorded as NF-kappa-B essential modulator NEMO, CC2-LZ domain, protein family^[6].
Optineurin's part of is recorded as NF-kappa-B essential modulator NEMO, N-terminal domain, protein family^[7].
Optineurin's part of is recorded as NEMO, Zinc finger, protein family^[8].
Optineurin's has part is recorded as NF-kappa-B essential modulator NEMO, CC2-LZ domain^[9].
Optineurin's has part is recorded as NF-kappa-B essential modulator NEMO, N-terminal^[10].
Optineurin's has part is recorded as NEMO, Zinc finger^[11].
Optineurin's RefSeq protein ID is recorded as NP_862896^[12].
Optineurin's RefSeq protein ID is recorded as XP_006497610^[13].
Optineurin's RefSeq protein ID is recorded as XP_006497611^[14].
Optineurin's RefSeq protein ID is recorded as XP_011237289^[15].
Optineurin's RefSeq protein ID is recorded as XP_011237290^[16].
Optineurin's RefSeq protein ID is recorded as NP_001343416^[17].
Optineurin's RefSeq protein ID is recorded as XP_030107949^[18].
Optineurin's molecular function is recorded as protein-macromolecule adaptor activity^[19].
Optineurin's molecular function is recorded as polyubiquitin modification-dependent protein binding^[20].
Optineurin's molecular function is recorded as protein C-terminus binding^[21].
Optineurin's molecular function is recorded as protein binding^[22].
Optineurin's molecular function is recorded as identical protein binding^[23].
Optineurin's molecular function is recorded as metal ion binding^[24].
Optineurin's molecular function is recorded as K63-linked polyubiquitin modification-dependent protein binding^[25].
Optineurin's molecular function is recorded as TFIIIA-class transcription factor binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Optineurin, NF-kappa-B essential modulator NEMO, CC2-LZ domain, protein family, NF-kappa-B essential modulator NEMO, N-terminal domain, protein family, NEMO, Zinc finger, protein family

Properties

Biological process Golgi organization, negative regulation of I-kappaB kinase/NF-kappaB signaling, autophagy, defense response to Gram-negative bacterium, Golgi ribbon formation, negative regulation of receptor recycling, vesicle-mediated transport, Golgi to plasma membrane protein transport, parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization, positive regulation of xenophagy, positive regulation of autophagy, Unfolded Protein Response, immune system process, innate immune response, protein localization to Golgi apparatus, positive regulation of cytokine production, positive regulation of cell population proliferation, negative regulation of cell population proliferation, positive regulation of gene expression, negative regulation of neuron apoptotic process, positive regulation of neuron apoptotic process, protein homooligomerization, positive regulation of neural precursor cell proliferation, protein localization to Golgi apparatus

Cell component recycling endosome, endosome, autophagosome, trans-Golgi network, cytosol, Golgi apparatus, nucleus, cytoplasm, axon, cytoplasmic vesicle, soma, perinuclear region of cytoplasm, cytoplasm, cytoplasmic vesicle

Encoded by Optn

Found in taxon house mouse

Has part(s) NF-kappa-B essential modulator NEMO, CC2-LZ domain, NF-kappa-B essential modulator NEMO, N-terminal, NEMO, Zinc finger

Imported from wholeness_audit_2026-05-02

Molecular function protein-macromolecule adaptor activity, polyubiquitin modification-dependent protein binding, protein C-terminus binding, protein binding, identical protein binding, metal ion binding, K63-linked polyubiquitin modification-dependent protein binding, TFIIIA-class transcription factor binding, ubiquitin binding, K63-linked polyubiquitin modification-dependent protein binding

External References (3)

Ensembl protein id ENSMUSP00000027986, ENSMUSP00000110648

Refseq protein id NP_862896, XP_006497610, XP_006497611, XP_011237289, XP_011237290, NP_001343416, XP_030107949

Uniprot protein id Q8K3K8

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Optineurin — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Optineurin — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Optineurin — UniProt protein ID (P352): Q8K3K8. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Optineurin — part of (P361): Optineurin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Optineurin — part of (P361): NF-kappa-B essential modulator NEMO, CC2-LZ domain, protein family. wikidata.org.
[7] ↑ Optineurin — part of (P361): NF-kappa-B essential modulator NEMO, N-terminal domain, protein family. wikidata.org.
[8] ↑ Optineurin — part of (P361): NEMO, Zinc finger, protein family. wikidata.org.
[9] ↑ Optineurin — has part(s) (P527): NF-kappa-B essential modulator NEMO, CC2-LZ domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Optineurin — has part(s) (P527): NF-kappa-B essential modulator NEMO, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Optineurin — has part(s) (P527): NEMO, Zinc finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Optineurin — RefSeq protein ID (P637): NP_862896. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Optineurin — RefSeq protein ID (P637): XP_006497610. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Optineurin — RefSeq protein ID (P637): XP_006497611. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Optineurin — RefSeq protein ID (P637): XP_011237289. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Optineurin — RefSeq protein ID (P637): XP_011237290. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Optineurin — RefSeq protein ID (P637): NP_001343416. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Optineurin — RefSeq protein ID (P637): XP_030107949. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Optineurin — molecular function (P680): protein-macromolecule adaptor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Optineurin — molecular function (P680): polyubiquitin modification-dependent protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Optineurin — molecular function (P680): protein C-terminus binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Optineurin — molecular function (P680): protein binding. Molecular cloning, genomic structure, and protein characterization of mouse optineurin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Optineurin — molecular function (P680): identical protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Optineurin — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Optineurin — molecular function (P680): K63-linked polyubiquitin modification-dependent protein binding. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Optineurin — molecular function (P680): TFIIIA-class transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Optineurin is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Optineurin. Retrieved May 3, 2026, from https://4ort.xyz/entity/optineurin

MLA “Optineurin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/optineurin.

BibTeX

@misc{4ortxyz_optineurin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Optineurin}}, year = {2026}, url = {https://4ort.xyz/entity/optineurin}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Optineurin — https://4ort.xyz/entity/optineurin (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/optineurin · Last refreshed: May 3, 2026