NLR family, pyrin domain containing 3

mammalian protein found in Rattus norvegicus

Protein protein Q30020988

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NLR family, pyrin domain containing 3

Summary

NLR family, pyrin domain containing 3 is a protein^[1].

Key Facts

NLR family, pyrin domain containing 3's instance of is recorded as protein^[2].
NLR family, pyrin domain containing 3's UniProt protein ID is recorded as D4A523^[3].
NLR family, pyrin domain containing 3's part of is recorded as Death-like domain superfamily^[4].
NLR family, pyrin domain containing 3's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[5].
NLR family, pyrin domain containing 3's part of is recorded as Leucine-rich repeat domain superfamily^[6].
NLR family, pyrin domain containing 3's part of is recorded as NACHT-associated domain, protein family^[7].
NLR family, pyrin domain containing 3's part of is recorded as NACHT nucleoside triphosphatase family^[8].
NLR family, pyrin domain containing 3's part of is recorded as DAPIN domain, protein family^[9].
NLR family, pyrin domain containing 3's part of is recorded as Leucine-rich repeat, protein family^[10].
NLR family, pyrin domain containing 3's has part is recorded as NACHT-associated domain^[11].
NLR family, pyrin domain containing 3's has part is recorded as Leucine-rich repeat^[12].
NLR family, pyrin domain containing 3's has part is recorded as DAPIN domain^[13].
NLR family, pyrin domain containing 3's has part is recorded as NACHT nucleoside triphosphatase domain^[14].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as NP_001178571^[15].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_006246515^[16].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_006246517^[17].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_006246519^[18].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_038941322^[19].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_038941323^[20].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_038941324^[21].
NLR family, pyrin domain containing 3's RefSeq protein ID is recorded as XP_038941325^[22].
NLR family, pyrin domain containing 3's molecular function is recorded as nucleotide binding^[23].
NLR family, pyrin domain containing 3's molecular function is recorded as ATP binding^[24].
NLR family, pyrin domain containing 3's molecular function is recorded as transcription factor binding^[25].
NLR family, pyrin domain containing 3's molecular function is recorded as identical protein binding^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Death-like domain superfamily, P-loop containing nucleoside triphosphate hydrolase, Leucine-rich repeat domain superfamily, NACHT-associated domain, protein family, NACHT nucleoside triphosphatase family, DAPIN domain, protein family, Leucine-rich repeat, protein family

Properties

Biological process immune system process, negative regulation of acute inflammatory response, positive regulation of type 2 immune response, transcription, DNA-templated, regulation of transcription, DNA-templated, activation of cysteine-type endopeptidase activity involved in apoptotic process, inflammatory response, negative regulation of NF-kappaB transcription factor activity, interleukin-1 beta production, interleukin-18 production, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, NLRP3 inflammasome complex assembly, innate immune response, positive regulation of T-helper 2 cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of inflammatory response, negative regulation of inflammatory response, positive regulation of NF-kappaB transcription factor activity, defense response to virus, cellular response to lipopolysaccharide, positive regulation of T-helper 17 cell differentiation, positive regulation of T-helper 2 cell cytokine production, biological process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, defense response to Gram-positive bacterium, cellular response to peptidoglycan, negative regulation of NIK/NF-kappaB signaling

Cell component extracellular region, nucleus, cytoplasm, endoplasmic reticulum, cytosol, inflammasome complex, NLRP3 inflammasome complex, cellular component, Golgi membrane

Encoded by Nlrp3

Found in taxon brown rat

Has part(s) NACHT-associated domain, Leucine-rich repeat, DAPIN domain, NACHT nucleoside triphosphatase domain

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, ATP binding, transcription factor binding, identical protein binding, sequence-specific DNA binding, molecular function

External References (3)

Ensembl protein id ENSRNOP00000004280, ENSRNOP00000072545

Refseq protein id NP_001178571, XP_006246515, XP_006246517, XP_006246519, XP_038941322, XP_038941323, XP_038941324, XP_038941325

Uniprot protein id D4A523

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ NLR family, pyrin domain containing 3 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ NLR family, pyrin domain containing 3 — UniProt protein ID (P352): D4A523. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ NLR family, pyrin domain containing 3 — part of (P361): Death-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ NLR family, pyrin domain containing 3 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ NLR family, pyrin domain containing 3 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ NLR family, pyrin domain containing 3 — part of (P361): NACHT-associated domain, protein family. wikidata.org.
[8] ↑ NLR family, pyrin domain containing 3 — part of (P361): NACHT nucleoside triphosphatase family. wikidata.org.
[9] ↑ NLR family, pyrin domain containing 3 — part of (P361): DAPIN domain, protein family. wikidata.org.
[10] ↑ NLR family, pyrin domain containing 3 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[11] ↑ NLR family, pyrin domain containing 3 — has part(s) (P527): NACHT-associated domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ NLR family, pyrin domain containing 3 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ NLR family, pyrin domain containing 3 — has part(s) (P527): DAPIN domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ NLR family, pyrin domain containing 3 — has part(s) (P527): NACHT nucleoside triphosphatase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): NP_001178571. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_006246515. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_006246517. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_006246519. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_038941322. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_038941323. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_038941324. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ NLR family, pyrin domain containing 3 — RefSeq protein ID (P637): XP_038941325. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ NLR family, pyrin domain containing 3 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ NLR family, pyrin domain containing 3 — molecular function (P680): ATP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ NLR family, pyrin domain containing 3 — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ NLR family, pyrin domain containing 3 — molecular function (P680): identical protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ NLR family, pyrin domain containing 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). NLR family, pyrin domain containing 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-3

MLA

“NLR family, pyrin domain containing 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-3.

BibTeX

@misc{4ortxyz_nlr-family-pyrin-domain-containing-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NLR family, pyrin domain containing 3}}, year = {2026}, url = {https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-3}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NLR family, pyrin domain containing 3 — https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-3 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-3 · Last refreshed: May 3, 2026