NLR family, CARD domain containing 4

mammalian protein found in Mus musculus

Protein protein Q21986189

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NLR family, CARD domain containing 4

Summary

NLR family, CARD domain containing 4 is a protein^[1].

Key Facts

NLR family, CARD domain containing 4's instance of is recorded as protein^[2].
NLR family, CARD domain containing 4's subclass of is recorded as protein^[3].
NLR family, CARD domain containing 4's UniProt protein ID is recorded as Q3UP24^[4].
NLR family, CARD domain containing 4's part of is recorded as Leucine-rich repeat domain superfamily^[5].
NLR family, CARD domain containing 4's part of is recorded as Death-like domain superfamily^[6].
NLR family, CARD domain containing 4's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[7].
NLR family, CARD domain containing 4's part of is recorded as NACHT nucleoside triphosphatase family^[8].
NLR family, CARD domain containing 4's part of is recorded as CARD domain, protein family^[9].
NLR family, CARD domain containing 4's has part is recorded as NACHT nucleoside triphosphatase domain^[10].
NLR family, CARD domain containing 4's has part is recorded as CARD domain^[11].
NLR family, CARD domain containing 4's RefSeq protein ID is recorded as NP_001028539^[12].
NLR family, CARD domain containing 4's RefSeq protein ID is recorded as XP_006524409^[13].
NLR family, CARD domain containing 4's RefSeq protein ID is recorded as XP_006524410^[14].
NLR family, CARD domain containing 4's RefSeq protein ID is recorded as XP_017172980^[15].
NLR family, CARD domain containing 4's PDB structure ID is recorded as 3JBL^[16].
NLR family, CARD domain containing 4's PDB structure ID is recorded as 4KXF^[17].
NLR family, CARD domain containing 4's PDB structure ID is recorded as 5AJ2^[18].
NLR family, CARD domain containing 4's molecular function is recorded as nucleotide binding^[19].
NLR family, CARD domain containing 4's molecular function is recorded as ubiquitin-protein transferase activity^[20].
NLR family, CARD domain containing 4's molecular function is recorded as protein homodimerization activity^[21].
NLR family, CARD domain containing 4's molecular function is recorded as ATP binding^[22].
NLR family, CARD domain containing 4's molecular function is recorded as cysteine-type endopeptidase inhibitor activity involved in apoptotic process^[23].
NLR family, CARD domain containing 4's molecular function is recorded as protein binding^[24].
NLR family, CARD domain containing 4's molecular function is recorded as identical protein binding^[25].
NLR family, CARD domain containing 4's molecular function is recorded as ATP binding^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Subclass of protein

Part of Leucine-rich repeat domain superfamily, Death-like domain superfamily, P-loop containing nucleoside triphosphate hydrolase, NACHT nucleoside triphosphatase family, CARD domain, protein family

Properties

Biological process regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of signal transduction, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, protein homooligomerization, apoptotic process, pyroptosis, mitotic spindle assembly, innate immune response, activation of innate immune response, immune system process, regulation of apoptotic process, defense response to bacterium, positive regulation of NF-kappaB transcription factor activity, detection of bacterium, positive regulation of apoptotic process, inflammatory response, activation of cysteine-type endopeptidase activity involved in apoptotic process, protein ubiquitination, activation of innate immune response, activation of cysteine-type endopeptidase activity involved in apoptotic process, inflammatory response, detection of bacterium, defense response to bacterium, regulation of apoptotic process, positive regulation of NF-kappaB transcription factor activity, protein homooligomerization, pyroptosis

Cell component cytoplasm, nucleus, IPAF inflammasome complex, cytosol, IPAF inflammasome complex

Encoded by Nlrc4

Found in taxon house mouse

Has part(s) NACHT nucleoside triphosphatase domain, CARD domain

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, ubiquitin-protein transferase activity, protein homodimerization activity, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, protein binding, identical protein binding, ATP binding, identical protein binding, protein homodimerization activity

External References (4)

Ensembl protein id ENSMUSP00000059637, ENSMUSP00000156704, ENSMUSP00000157167

Pdb structure id 3JBL, 4KXF, 5AJ2

Refseq protein id NP_001028539, XP_006524409, XP_006524410, XP_017172980

Uniprot protein id Q3UP24

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ NLR family, CARD domain containing 4 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ NLR family, CARD domain containing 4 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ NLR family, CARD domain containing 4 — UniProt protein ID (P352): Q3UP24. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ NLR family, CARD domain containing 4 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ NLR family, CARD domain containing 4 — part of (P361): Death-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ NLR family, CARD domain containing 4 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ NLR family, CARD domain containing 4 — part of (P361): NACHT nucleoside triphosphatase family. wikidata.org.
[9] ↑ NLR family, CARD domain containing 4 — part of (P361): CARD domain, protein family. wikidata.org.
[10] ↑ NLR family, CARD domain containing 4 — has part(s) (P527): NACHT nucleoside triphosphatase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ NLR family, CARD domain containing 4 — has part(s) (P527): CARD domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ NLR family, CARD domain containing 4 — RefSeq protein ID (P637): NP_001028539. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ NLR family, CARD domain containing 4 — RefSeq protein ID (P637): XP_006524409. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ NLR family, CARD domain containing 4 — RefSeq protein ID (P637): XP_006524410. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ NLR family, CARD domain containing 4 — RefSeq protein ID (P637): XP_017172980. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ NLR family, CARD domain containing 4 — PDB structure ID (P638): 3JBL. Q905695. Retrieved 2016-08-10. wikidata.org.
[17] ↑ NLR family, CARD domain containing 4 — PDB structure ID (P638): 4KXF. Q905695. Retrieved 2016-08-10. wikidata.org.
[18] ↑ NLR family, CARD domain containing 4 — PDB structure ID (P638): 5AJ2. Q905695. Retrieved 2016-08-10. wikidata.org.
[19] ↑ NLR family, CARD domain containing 4 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ NLR family, CARD domain containing 4 — molecular function (P680): ubiquitin-protein transferase activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ NLR family, CARD domain containing 4 — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ NLR family, CARD domain containing 4 — molecular function (P680): ATP binding. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ NLR family, CARD domain containing 4 — molecular function (P680): cysteine-type endopeptidase inhibitor activity involved in apoptotic process. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ NLR family, CARD domain containing 4 — molecular function (P680): protein binding. Phosphorylation of NLRC4 is critical for inflammasome activation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ NLR family, CARD domain containing 4 — molecular function (P680): identical protein binding. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ NLR family, CARD domain containing 4 — molecular function (P680): ATP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ NLR family, CARD domain containing 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). NLR family, CARD domain containing 4. Retrieved May 3, 2026, from https://4ort.xyz/entity/nlr-family-card-domain-containing-4-q21986189

MLA

“NLR family, CARD domain containing 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nlr-family-card-domain-containing-4-q21986189.

BibTeX

@misc{4ortxyz_nlr-family-card-domain-containing-4-q21986189_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NLR family, CARD domain containing 4}}, year = {2026}, url = {https://4ort.xyz/entity/nlr-family-card-domain-containing-4-q21986189}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NLR family, CARD domain containing 4 — https://4ort.xyz/entity/nlr-family-card-domain-containing-4-q21986189 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nlr-family-card-domain-containing-4-q21986189 · Last refreshed: May 3, 2026