NEDD4 family E3 ubiquitin-protein ligase YER125W

fungal protein found in Saccharomyces cerevisiae S288c

Protein protein Q27547704

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NEDD4 family E3 ubiquitin-protein ligase YER125W

Summary

NEDD4 family E3 ubiquitin-protein ligase YER125W is a protein^[1].

Key Facts

NEDD4 family E3 ubiquitin-protein ligase YER125W's instance of is recorded as protein^[2].
NEDD4 family E3 ubiquitin-protein ligase YER125W's subclass of is recorded as protein^[3].
NEDD4 family E3 ubiquitin-protein ligase YER125W's UniProt protein ID is recorded as P39940^[4].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as HECT, E3 ligase catalytic domain^[5].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as WW domain superfamily^[6].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as C2 domain superfamily^[7].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as E3 ubiquitin-protein ligase, SMURF1 type^[8].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as P-P-bond-hydrolysis-driven transporter^[9].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as auxiliary protein involved in transmembrane transport^[10].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as ESCRT-III family^[11].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as HECT domain, protein family^[12].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as C2 domain, protein family^[13].
NEDD4 family E3 ubiquitin-protein ligase YER125W's part of is recorded as WW domain, protein family^[14].
NEDD4 family E3 ubiquitin-protein ligase YER125W's has part is recorded as HECT domain^[15].
NEDD4 family E3 ubiquitin-protein ligase YER125W's has part is recorded as C2 domain^[16].
NEDD4 family E3 ubiquitin-protein ligase YER125W's has part is recorded as WW domain^[17].
NEDD4 family E3 ubiquitin-protein ligase YER125W's RefSeq protein ID is recorded as NP_011051^[18].
NEDD4 family E3 ubiquitin-protein ligase YER125W's molecular function is recorded as ubiquitin-protein transferase activity^[19].
NEDD4 family E3 ubiquitin-protein ligase YER125W's molecular function is recorded as ubiquitin binding^[20].
NEDD4 family E3 ubiquitin-protein ligase YER125W's molecular function is recorded as phosphatidylinositol binding^[21].
NEDD4 family E3 ubiquitin-protein ligase YER125W's molecular function is recorded as protein binding^[22].
NEDD4 family E3 ubiquitin-protein ligase YER125W's molecular function is recorded as transferase activity^[23].
NEDD4 family E3 ubiquitin-protein ligase YER125W's molecular function is recorded as ubiquitin protein ligase activity^[24].
NEDD4 family E3 ubiquitin-protein ligase YER125W's cell component is recorded as Golgi apparatus^[25].
NEDD4 family E3 ubiquitin-protein ligase YER125W's cell component is recorded as nucleus^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of HECT, E3 ligase catalytic domain, WW domain superfamily, C2 domain superfamily, E3 ubiquitin-protein ligase, SMURF1 type, P-P-bond-hydrolysis-driven transporter, auxiliary protein involved in transmembrane transport, ESCRT-III family, HECT domain, protein family, C2 domain, protein family, WW domain, protein family

Properties

Biological process cellular response to UV, positive regulation of fatty acid biosynthetic process, regulation of mRNA export from nucleus, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of actin cytoskeleton organization, ubiquitin-dependent endocytosis, regulation of dolichol biosynthetic process, positive regulation of endocytosis, regulation of tRNA export from nucleus, protein autoubiquitination, positive regulation of receptor-mediated endocytosis, protein polyubiquitination, regulation of ergosterol biosynthetic process, regulation of tRNA processing, regulation of rRNA processing, regulation of initiation of mating projection growth, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, regulation of ubiquinone biosynthetic process, regulation of multivesicular body size, late endosome to vacuole transport via multivesicular body sorting pathway, regulation of ribosomal large subunit export from nucleus, regulation of protein localization, protein monoubiquitination, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of phosphate metabolic process, mitochondrion organization, ribophagy, protein ubiquitination, regulation of nitrogen utilization, poly(A)+ mRNA export from nucleus, mitochondria-associated ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process, protein ubiquitination, protein polyubiquitination, ubiquitin-dependent protein catabolic process, protein ubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, positive regulation of protein catabolic process

Cell component Golgi apparatus, nucleus, extrinsic component of cytoplasmic side of plasma membrane, cellular bud tip, cytoplasm, endosome membrane, cytoskeleton, actin cortical patch, ubiquitin ligase complex, cytoplasm, mitochondrion, plasma membrane

Encoded by RSP5

Found in taxon Saccharomyces cerevisiae S288c

Has part(s) HECT domain, C2 domain, WW domain

Imported from wholeness_audit_2026-05-02

Molecular function ubiquitin-protein transferase activity, ubiquitin binding, phosphatidylinositol binding, protein binding, transferase activity, ubiquitin protein ligase activity

External References (5)

Ensembl protein id YER125W

Refseq protein id NP_011051

Saccharomyces genome database id S000000927

Transporter classification database id 3.A.31.1.1, 8.A.30.1.4

Uniprot protein id P39940

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — subclass of (P279): protein. Q20641742. Retrieved 2016-12-10. wikidata.org.
[4] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — UniProt protein ID (P352): P39940. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): HECT, E3 ligase catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): WW domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): E3 ubiquitin-protein ligase, SMURF1 type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): P-P-bond-hydrolysis-driven transporter. Retrieved 2019-10-02. wikidata.org.
[10] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): auxiliary protein involved in transmembrane transport. Retrieved 2019-10-02. wikidata.org.
[11] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): ESCRT-III family. Retrieved 2019-10-02. wikidata.org.
[12] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): HECT domain, protein family. wikidata.org.
[13] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): C2 domain, protein family. wikidata.org.
[14] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — part of (P361): WW domain, protein family. wikidata.org.
[15] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — has part(s) (P527): HECT domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — has part(s) (P527): C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — has part(s) (P527): WW domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — RefSeq protein ID (P637): NP_011051. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — molecular function (P680): ubiquitin-protein transferase activity. A bacterial genetic selection system for ubiquitylation cascade discovery. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — molecular function (P680): ubiquitin binding. Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — molecular function (P680): phosphatidylinositol binding. The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — molecular function (P680): protein binding. Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — molecular function (P680): transferase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — molecular function (P680): ubiquitin protein ligase activity. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — cell component (P681): Golgi apparatus. Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W — cell component (P681): nucleus. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ NEDD4 family E3 ubiquitin-protein ligase YER125W is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“NEDD4 family E3 ubiquitin-protein ligase YER125W.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w.

BibTeX

@misc{4ortxyz_nedd4-family-e3-ubiquitin-protein-ligase-yer125w_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NEDD4 family E3 ubiquitin-protein ligase YER125W}}, year = {2026}, url = {https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NEDD4 family E3 ubiquitin-protein ligase YER125W — https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w · Last refreshed: May 3, 2026