MYD88, innate immune signal transduction adaptor

mammalian protein found in Rattus norvegicus

Protein protein Q28560463

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MYD88, innate immune signal transduction adaptor

Summary

MYD88, innate immune signal transduction adaptor is a protein^[1].

Key Facts

MYD88, innate immune signal transduction adaptor's instance of is recorded as protein^[2].
MYD88, innate immune signal transduction adaptor's subclass of is recorded as protein^[3].
MYD88, innate immune signal transduction adaptor's UniProt protein ID is recorded as Q6Y1S1^[4].
MYD88, innate immune signal transduction adaptor's part of is recorded as Myeloid differentiation primary response protein MyD88^[5].
MYD88, innate immune signal transduction adaptor's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain superfamily^[6].
MYD88, innate immune signal transduction adaptor's part of is recorded as Death-like domain superfamily^[7].
MYD88, innate immune signal transduction adaptor's part of is recorded as Death domain, protein family^[8].
MYD88, innate immune signal transduction adaptor's part of is recorded as MyD88, death domain, protein family^[9].
MYD88, innate immune signal transduction adaptor's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain, protein family^[10].
MYD88, innate immune signal transduction adaptor's has part is recorded as MyD88, death domain^[11].
MYD88, innate immune signal transduction adaptor's has part is recorded as death domain^[12].
MYD88, innate immune signal transduction adaptor's has part is recorded as Toll/interleukin-1 receptor homology (TIR) domain^[13].
MYD88, innate immune signal transduction adaptor's RefSeq protein ID is recorded as NP_937763^[14].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as signaling receptor binding^[15].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as Toll binding^[16].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as interleukin-1 receptor binding^[17].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as protein binding^[18].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as Toll-like receptor binding^[19].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as TIR domain binding^[20].
MYD88, innate immune signal transduction adaptor's molecular function is recorded as Toll-like receptor binding^[21].
MYD88, innate immune signal transduction adaptor's cell component is recorded as nucleus^[22].
MYD88, innate immune signal transduction adaptor's cell component is recorded as cytoplasm^[23].
MYD88, innate immune signal transduction adaptor's cell component is recorded as cytosol^[24].
MYD88, innate immune signal transduction adaptor's cell component is recorded as plasma membrane^[25].
MYD88, innate immune signal transduction adaptor's cell component is recorded as postsynaptic density^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Myeloid differentiation primary response protein MyD88, Toll/interleukin-1 receptor homology (TIR) domain superfamily, Death-like domain superfamily, Death domain, protein family, MyD88, death domain, protein family, Toll/interleukin-1 receptor homology (TIR) domain, protein family

Properties

Biological process response to molecule of fungal origin, immune system process, MyD88-dependent toll-like receptor signaling pathway, inflammatory response, signal transduction, cell surface receptor signaling pathway, JNK cascade, Toll signaling pathway, response to virus, induced systemic resistance, regulation of gene expression, positive regulation of gene expression, immunoglobulin mediated immune response, cytokine-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, response to peptidoglycan, response to lipopolysaccharide, regulation of interleukin-6 production, regulation of tumor necrosis factor production, positive regulation of interleukin-17 production, positive regulation of interleukin-23 production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, regulation of cell population proliferation, positive regulation of I-kappaB kinase/NF-kappaB signaling, innate immune response, positive regulation of JNK cascade, positive regulation of smooth muscle cell proliferation, positive regulation of lymphocyte proliferation, regulation of inflammatory response, defense response to Gram-positive bacterium, positive regulation of NF-kappaB transcription factor activity, establishment of endothelial intestinal barrier, cellular response to oxidised low-density lipoprotein particle stimulus, positive regulation of cytokine production involved in inflammatory response, regulation of neutrophil migration, regulation of chemokine (C-X-C motif) ligand 1 production, regulation of chemokine (C-X-C motif) ligand 2 production, phagocytosis, Toll signaling pathway, innate immune response, defense response to Gram-positive bacterium

Cell component nucleus, cytoplasm, cytosol, plasma membrane, postsynaptic density, protein-containing complex, plasma membrane

Encoded by Myd88

Found in taxon brown rat

Has part(s) MyD88, death domain, death domain, Toll/interleukin-1 receptor homology (TIR) domain

Imported from wholeness_audit_2026-05-02

Molecular function signaling receptor binding, Toll binding, interleukin-1 receptor binding, protein binding, Toll-like receptor binding, TIR domain binding, Toll-like receptor binding

External References (3)

Ensembl protein id ENSRNOP00000018341

Refseq protein id NP_937763

Uniprot protein id Q6Y1S1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ MYD88, innate immune signal transduction adaptor — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ MYD88, innate immune signal transduction adaptor — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ MYD88, innate immune signal transduction adaptor — UniProt protein ID (P352): Q6Y1S1. Q905695. Retrieved 2021-11-17. wikidata.org.
[5] ↑ MYD88, innate immune signal transduction adaptor — part of (P361): Myeloid differentiation primary response protein MyD88. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ MYD88, innate immune signal transduction adaptor — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ MYD88, innate immune signal transduction adaptor — part of (P361): Death-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ MYD88, innate immune signal transduction adaptor — part of (P361): Death domain, protein family. wikidata.org.
[9] ↑ MYD88, innate immune signal transduction adaptor — part of (P361): MyD88, death domain, protein family. wikidata.org.
[10] ↑ MYD88, innate immune signal transduction adaptor — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain, protein family. wikidata.org.
[11] ↑ MYD88, innate immune signal transduction adaptor — has part(s) (P527): MyD88, death domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ MYD88, innate immune signal transduction adaptor — has part(s) (P527): death domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ MYD88, innate immune signal transduction adaptor — has part(s) (P527): Toll/interleukin-1 receptor homology (TIR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ MYD88, innate immune signal transduction adaptor — RefSeq protein ID (P637): NP_937763. Q20641742. Retrieved 2021-09-07. wikidata.org.
[15] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): signaling receptor binding. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): Toll binding. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): interleukin-1 receptor binding. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): protein binding. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): Toll-like receptor binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): TIR domain binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ MYD88, innate immune signal transduction adaptor — molecular function (P680): Toll-like receptor binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ MYD88, innate immune signal transduction adaptor — cell component (P681): nucleus. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ MYD88, innate immune signal transduction adaptor — cell component (P681): cytoplasm. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ MYD88, innate immune signal transduction adaptor — cell component (P681): cytosol. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ MYD88, innate immune signal transduction adaptor — cell component (P681): plasma membrane. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ MYD88, innate immune signal transduction adaptor — cell component (P681): postsynaptic density. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ MYD88, innate immune signal transduction adaptor is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). MYD88, innate immune signal transduction adaptor. Retrieved May 3, 2026, from https://4ort.xyz/entity/myd88-innate-immune-signal-transduction-adaptor-q28560463

MLA

“MYD88, innate immune signal transduction adaptor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/myd88-innate-immune-signal-transduction-adaptor-q28560463.

BibTeX

@misc{4ortxyz_myd88-innate-immune-signal-transduction-adaptor-q28560463_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{MYD88, innate immune signal transduction adaptor}}, year = {2026}, url = {https://4ort.xyz/entity/myd88-innate-immune-signal-transduction-adaptor-q28560463}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): MYD88, innate immune signal transduction adaptor — https://4ort.xyz/entity/myd88-innate-immune-signal-transduction-adaptor-q28560463 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/myd88-innate-immune-signal-transduction-adaptor-q28560463 · Last refreshed: May 3, 2026