Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

mammalian protein found in Homo sapiens
Protein protein Q21111753
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Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

Summary

Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is a protein[1]. It draws 9 Wikipedia views per month (protein category, ranking #151 of 987).[2]

Key Facts

  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's instance of is recorded as protein[3].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of formate-tetrahydrofolate ligase[4].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of NAD(P)-binding domain superfamily[5].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of Tetrahydrofolate dehydrogenase/cyclohydrolase[6].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of P-loop containing nucleoside triphosphate hydrolase[7].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, protein family[8].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, protein family[9].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of Formate-tetrahydrofolate ligase, FTHFS, conserved site, protein family[10].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 is part of Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site, protein family[11].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's Commons category is recorded as MTHFD1[12].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 comprises Formate-tetrahydrofolate ligase, FTHFS, conserved site[13].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 comprises Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain[14].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 comprises Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site[15].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 comprises Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain[16].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as nucleotide binding[17].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as methylenetetrahydrofolate dehydrogenase (NADP+) activity[18].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as methylenetetrahydrofolate dehydrogenase (NAD+) activity[19].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as ligase activity[20].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity[21].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as catalytic activity[22].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as oxidoreductase activity[23].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as ATP binding[24].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as hydrolase activity[25].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as protein binding[26].
  • Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1's molecular function is recorded as formate-tetrahydrofolate ligase activity[27].

Why It Matters

Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 draws 9 Wikipedia views per month (protein category, ranking #151 of 987).[2] It is known by 7 alternative names across languages and contexts.[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] . wikidata.org.
  7. [9] . wikidata.org.
  8. [10] . wikidata.org.
  9. [11] . wikidata.org.
  10. [12] . wikidata.org.
  11. [13] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1
MLA “Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1.
BibTeX @misc{4ortxyz_methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1}}, year = {2026}, url = {https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 — https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13d ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon Homo sapiens
    Instance of
    Encoded by MTHFD1
    Cell component membrane, mitochondrion, extracellular exosome +5
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 1.5.1.5, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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