lissencephaly

brain disorder that prevents growth of brain folds
MedicalCondition developmental_defect_during_embryogenesis Q1544416
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lissencephaly

Summary

lissencephaly is a developmental defect during embryogenesis[1]. lissencephaly has Wikipedia articles in 16 language editions, a strong signal of global cultural recognition.[2]

Key Facts

  • lissencephaly's instance of is recorded as developmental defect during embryogenesis[3].
  • lissencephaly's instance of is recorded as designated intractable/rare disease[4].
  • lissencephaly's instance of is recorded as rare disease[5].
  • lissencephaly's instance of is recorded as class of disease[6].
  • lissencephaly's instance of is recorded as symptom or sign[7].
  • lissencephaly is a type of nervous system malformations[8].
  • lissencephaly is a type of neuronal migration disorder[9].
  • lissencephaly is a type of syndrome with a central nervous system malformation as major feature[10].
  • lissencephaly is a type of cerebral malformation with epilepsy[11].
  • lissencephaly is a type of rare genetic developmental defect during embryogenesis[12].
  • lissencephaly is a type of genetic syndromic intellectual disability[13].
  • lissencephaly is a type of classical lissencephalies and subcortical band heterotopias[14].
  • lissencephaly is a type of disease[15].
  • lissencephaly's Commons category is recorded as Lissencephaly[16].
  • lissencephaly's ICPC 2 ID is recorded as N85[17].
  • lissencephaly's external data available at URL is recorded as http://www.nanbyou.or.jp/entry/4396[18].
  • lissencephaly's NCI Thesaurus ID is recorded as C103921[19].
  • lissencephaly's health specialty is recorded as medical genetics[20].
  • lissencephaly's health specialty is recorded as neurology[21].
  • lissencephaly's genetic association is recorded as TUBA1A[22].
  • lissencephaly's genetic association is recorded as PAFAH1B1[23].
  • lissencephaly's genetic association is recorded as ARX[24].
  • lissencephaly's genetic association is recorded as LAMB1[25].
  • lissencephaly's genetic association is recorded as DCX[26].
  • lissencephaly's genetic association is recorded as NDE1[27].

Why It Matters

lissencephaly has Wikipedia articles in 16 language editions, a strong signal of global cultural recognition.[2] lissencephaly is known by 16 alternative names across languages and contexts.[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Monarch Disease Ontology release 2018-06-29. Retrieved . wikidata.org.
  2. [4] . ddrare.nibiohn.go.jp. Retrieved . ddrare.nibiohn.go.jp. Provenance: wikidata.org.
  3. [5] . wikidata.org.
  4. [6] . wikidata.org.
  5. [7] . wikidata.org.
  6. [8] . Disease Ontology. Retrieved . wikidata.org.
  7. [9] . wikidata.org.
  8. [10] . Monarch Disease Ontology release 2018-06-29. Retrieved . wikidata.org.
  9. [11] . Monarch Disease Ontology release 2018-06-29. Retrieved . wikidata.org.
  10. [12] . Monarch Disease Ontology release 2018-06-29. Retrieved . wikidata.org.
  11. [13] . Monarch Disease Ontology release 2018-06-29. Retrieved . wikidata.org.
  12. [14] . wikidata.org.
  13. [15] . wikidata.org.
  14. [16] . wikidata.org.
  15. [17] . wikidata.org.
  16. [18] . ddrare.nibiohn.go.jp. Retrieved . ddrare.nibiohn.go.jp. Provenance: wikidata.org.
  17. [19] . Disease Ontology. Retrieved . wikidata.org.
  18. [20] . wikidata.org.
  19. [21] . wikidata.org.
  20. [22] . Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).. wikidata.org.
  21. [23] . Clinical and molecular basis of classical lissencephaly: Mutations in the LIS1 gene (PAFAH1B1).. wikidata.org.
  22. [24] . Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. wikidata.org.
  23. [25] . Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. wikidata.org.
  24. [26] . A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Retrieved . search.clinicalgenome.org. Provenance: wikidata.org.
  25. [27] . The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikidata sitelinks. wikidata.org.
  2. [28] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). lissencephaly. Retrieved May 3, 2026, from https://4ort.xyz/entity/lissencephaly
MLA “lissencephaly.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lissencephaly.
BibTeX @misc{4ortxyz_lissencephaly_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{lissencephaly}}, year = {2026}, url = {https://4ort.xyz/entity/lissencephaly}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): lissencephaly — https://4ort.xyz/entity/lissencephaly (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 10d ago · JhealdBatch bot · 2026-07-05 view diff on Wikidata ↗
    Subclass of nervous system malformations, neuronal migration disorder, syndrome with a central nervous system malformation as major feature +5
    Instance of developmental defect during embryogenesis, designated intractable/rare disease, rare disease +2
    "/* wbeditentity-update:0| */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/39953|batch #39953]]: deprecate redundant disease superclasses (2)"
  2. 12d ago · JhealdBatch bot · 2026-07-03 view diff on Wikidata ↗
    Subclass of nervous system malformations, neuronal migration disorder, syndrome with a central nervous system malformation as major feature +5
    Health specialty medical genetics, neurology
    Genetic association TUBA1A, PAFAH1B1, ARX +4
    Subclass of
    + 4 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update:0| */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/39732|batch #39732]]: rm redundant subclass"
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