Leucine-rich repeat kinase 2

mammalian protein found in Rattus norvegicus

Protein protein Q29518499

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Leucine-rich repeat kinase 2

Summary

Leucine-rich repeat kinase 2 is a protein^[1].

Key Facts

Leucine-rich repeat kinase 2's instance of is recorded as protein^[2].
Leucine-rich repeat kinase 2's UniProt protein ID is recorded as F1LNJ1^[3].
Leucine-rich repeat kinase 2's part of is recorded as WD40/YVTN repeat-like-containing domain superfamily^[4].
Leucine-rich repeat kinase 2's part of is recorded as Protein kinase-like domain superfamily^[5].
Leucine-rich repeat kinase 2's part of is recorded as Armadillo-like helical^[6].
Leucine-rich repeat kinase 2's part of is recorded as Ankyrin repeat-containing domain superfamily^[7].
Leucine-rich repeat kinase 2's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[8].
Leucine-rich repeat kinase 2's part of is recorded as Armadillo-type fold^[9].
Leucine-rich repeat kinase 2's part of is recorded as Leucine-rich repeat domain superfamily^[10].
Leucine-rich repeat kinase 2's part of is recorded as WD40-repeat-containing domain superfamily^[11].
Leucine-rich repeat kinase 2's part of is recorded as C-terminal of Roc (COR) domain, protein family^[12].
Leucine-rich repeat kinase 2's part of is recorded as Roc domain, protein family^[13].
Leucine-rich repeat kinase 2's part of is recorded as Protein kinase domain, protein family^[14].
Leucine-rich repeat kinase 2's part of is recorded as Small GTP-binding protein domain family^[15].
Leucine-rich repeat kinase 2's part of is recorded as Leucine-rich repeat, typical subtype, protein family^[16].
Leucine-rich repeat kinase 2's part of is recorded as Protein kinase, ATP binding site, protein family^[17].
Leucine-rich repeat kinase 2's part of is recorded as Leucine-rich repeat, protein family^[18].
Leucine-rich repeat kinase 2's part of is recorded as Serine/threonine-protein kinase, active site, protein family^[19].
Leucine-rich repeat kinase 2's has part is recorded as leucine-rich repeat, typical subtype^[20].
Leucine-rich repeat kinase 2's has part is recorded as C-terminal of Roc (COR) domain^[21].
Leucine-rich repeat kinase 2's has part is recorded as Roc domain^[22].
Leucine-rich repeat kinase 2's has part is recorded as protein kinase, ATP binding site^[23].
Leucine-rich repeat kinase 2's has part is recorded as serine/threonine-protein kinase, active site^[24].
Leucine-rich repeat kinase 2's has part is recorded as small GTP-binding protein domain^[25].
Leucine-rich repeat kinase 2's has part is recorded as Leucine-rich repeat^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of WD40/YVTN repeat-like-containing domain superfamily, Protein kinase-like domain superfamily, Armadillo-like helical, Ankyrin repeat-containing domain superfamily, P-loop containing nucleoside triphosphate hydrolase, Armadillo-type fold, Leucine-rich repeat domain superfamily, WD40-repeat-containing domain superfamily, C-terminal of Roc (COR) domain, protein family, Roc domain, protein family, Protein kinase domain, protein family, Small GTP-binding protein domain family, Leucine-rich repeat, typical subtype, protein family, Protein kinase, ATP binding site, protein family, Leucine-rich repeat, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process MAPK cascade, negative regulation of protein phosphorylation, positive regulation of protein phosphorylation, protein phosphorylation, endocytosis, response to oxidative stress, mitochondrion organization, endoplasmic reticulum organization, Golgi organization, lysosome organization, spermatogenesis, neuromuscular junction development, determination of adult lifespan, cellular response to starvation, regulation of gene expression, regulation of autophagy, positive regulation of autophagy, regulation of protein kinase A signaling, negative regulation of protein processing, negative regulation of neuron projection development, regulation of neuron maturation, negative regulation of macroautophagy, phosphorylation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, calcium-mediated signaling, striatum development, olfactory bulb development, tangential migration from the subventricular zone to the olfactory bulb, positive regulation of protein ubiquitination, regulation of protein stability, negative regulation of protein binding, positive regulation of protein binding, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of GTPase activity, cellular response to oxidative stress, intracellular signal transduction, regulation of kidney size, exploration behavior, locomotory exploration behavior, regulation of lysosomal lumen pH, regulation of locomotion, regulation of membrane potential, positive regulation of programmed cell death, positive regulation of GTPase activity, GTP metabolic process, protein autophosphorylation, intracellular distribution of mitochondria, neuron projection morphogenesis, mitochondrion localization, positive regulation of nitric-oxide synthase biosynthetic process, regulation of mitochondrial depolarization, regulation of synaptic transmission, glutamatergic, excitatory postsynaptic potential, regulation of dopamine receptor signaling pathway, positive regulation of dopamine receptor signaling pathway, regulation of ER to Golgi vesicle-mediated transport, regulation of canonical Wnt signaling pathway, regulation of dendritic spine morphogenesis, protein localization to endoplasmic reticulum exit site, neuron death, cellular response to manganese ion, cellular response to organic cyclic compound, reactive oxygen species metabolic process, positive regulation of canonical Wnt signaling pathway, negative regulation of excitatory postsynaptic potential, neuron projection arborization, regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle endocytosis, regulation of neuron death, negative regulation of neuron death, positive regulation of histone deacetylase activity, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of protein autoubiquitination, regulation of neuroblast proliferation, regulation of synaptic vesicle transport, negative regulation of autophagosome assembly, negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation, negative regulation of hydrogen peroxide-induced cell death, negative regulation of protein targeting to mitochondrion, cellular response to dopamine, positive regulation of microglial cell activation, Wnt signalosome assembly, regulation of retrograde transport, endosome to Golgi, regulation of CAMKK-AMPK signaling cascade, regulation of branching morphogenesis of a nerve, regulation of synaptic vesicle exocytosis, protein import into nucleus

Cell component nucleus, cytoplasm, mitochondrion, mitochondrial outer membrane, mitochondrial inner membrane, mitochondrial matrix, lysosome, endosome, endoplasmic reticulum, Golgi apparatus, Golgi-associated vesicle, trans-Golgi network, cytosol, plasma membrane, microvillus, synaptic vesicle, membrane, inclusion body, axon, dendrite, growth cone, cytoplasmic vesicle, mitochondrial membranes, cytoplasmic side of mitochondrial outer membrane, dendrite cytoplasm, neuron projection, soma, perikaryon, intracellular membrane-bounded organelle, amphisome, autolysosome, membrane raft, synapse, endoplasmic reticulum exit site, multivesicular body, internal vesicle, postsynapse, glutamatergic synapse, caveola neck, presynaptic cytosol, ribonucleoprotein complex, Wnt signalosome

Encoded by Lrrk2

Found in taxon brown rat

Has part(s) leucine-rich repeat, typical subtype, C-terminal of Roc (COR) domain, Roc domain, protein kinase, ATP binding site, serine/threonine-protein kinase, active site, small GTP-binding protein domain, Leucine-rich repeat, protein kinase domain

Imported from wholeness_audit_2026-05-02

Molecular function SNARE binding, magnesium ion binding, molecular function, actin binding, GTPase activity, protein kinase activity, protein serine/threonine kinase activity, MAP kinase kinase activity, GTPase activator activity, ATP binding, GTP binding, tubulin binding, kinase activity, syntaxin-1 binding, clathrin binding, GTP-dependent protein kinase activity, peroxidase inhibitor activity, identical protein binding, protein homodimerization activity, transmembrane transporter binding, protein kinase A binding, beta-catenin destruction complex binding

External References (3)

Ensembl protein id ENSRNOP00000005438, ENSRNOP00000087057

Refseq protein id NP_001178718, XP_006242252, XP_008763911, XP_038934829, XP_038934830, XP_038934831

Uniprot protein id F1LNJ1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Leucine-rich repeat kinase 2 — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ Leucine-rich repeat kinase 2 — UniProt protein ID (P352): F1LNJ1. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ Leucine-rich repeat kinase 2 — part of (P361): WD40/YVTN repeat-like-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Leucine-rich repeat kinase 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Leucine-rich repeat kinase 2 — part of (P361): Armadillo-like helical. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Leucine-rich repeat kinase 2 — part of (P361): Ankyrin repeat-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Leucine-rich repeat kinase 2 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Leucine-rich repeat kinase 2 — part of (P361): Armadillo-type fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Leucine-rich repeat kinase 2 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Leucine-rich repeat kinase 2 — part of (P361): WD40-repeat-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Leucine-rich repeat kinase 2 — part of (P361): C-terminal of Roc (COR) domain, protein family. wikidata.org.
[13] ↑ Leucine-rich repeat kinase 2 — part of (P361): Roc domain, protein family. wikidata.org.
[14] ↑ Leucine-rich repeat kinase 2 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[15] ↑ Leucine-rich repeat kinase 2 — part of (P361): Small GTP-binding protein domain family. wikidata.org.
[16] ↑ Leucine-rich repeat kinase 2 — part of (P361): Leucine-rich repeat, typical subtype, protein family. wikidata.org.
[17] ↑ Leucine-rich repeat kinase 2 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[18] ↑ Leucine-rich repeat kinase 2 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[19] ↑ Leucine-rich repeat kinase 2 — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[20] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): leucine-rich repeat, typical subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): C-terminal of Roc (COR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): Roc domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): small GTP-binding protein domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Leucine-rich repeat kinase 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Leucine-rich repeat kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q29518499

MLA

“Leucine-rich repeat kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q29518499.

BibTeX

@misc{4ortxyz_leucine-rich-repeat-kinase-2-q29518499_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Leucine-rich repeat kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q29518499}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Leucine-rich repeat kinase 2 — https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q29518499 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q29518499 · Last refreshed: May 3, 2026