Leucine-rich repeat kinase 2

mammalian protein found in Mus musculus

Protein protein Q15331171

Press Enter · cited answer in seconds

Leucine-rich repeat kinase 2

Summary

Leucine-rich repeat kinase 2 is a protein^[1].

Key Facts

Leucine-rich repeat kinase 2's instance of is recorded as protein^[2].
Leucine-rich repeat kinase 2's subclass of is recorded as protein^[3].
Leucine-rich repeat kinase 2's UniProt protein ID is recorded as Q5S006^[4].
Leucine-rich repeat kinase 2's part of is recorded as WD40/YVTN repeat-like-containing domain superfamily^[5].
Leucine-rich repeat kinase 2's part of is recorded as Protein kinase-like domain superfamily^[6].
Leucine-rich repeat kinase 2's part of is recorded as Armadillo-like helical^[7].
Leucine-rich repeat kinase 2's part of is recorded as Ankyrin repeat-containing domain superfamily^[8].
Leucine-rich repeat kinase 2's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[9].
Leucine-rich repeat kinase 2's part of is recorded as Armadillo-type fold^[10].
Leucine-rich repeat kinase 2's part of is recorded as Leucine-rich repeat domain superfamily^[11].
Leucine-rich repeat kinase 2's part of is recorded as WD40-repeat-containing domain superfamily^[12].
Leucine-rich repeat kinase 2's part of is recorded as C-terminal of Roc (COR) domain, protein family^[13].
Leucine-rich repeat kinase 2's part of is recorded as Roc domain, protein family^[14].
Leucine-rich repeat kinase 2's part of is recorded as Protein kinase domain, protein family^[15].
Leucine-rich repeat kinase 2's part of is recorded as Small GTP-binding protein domain family^[16].
Leucine-rich repeat kinase 2's part of is recorded as Leucine-rich repeat, typical subtype, protein family^[17].
Leucine-rich repeat kinase 2's part of is recorded as Protein kinase, ATP binding site, protein family^[18].
Leucine-rich repeat kinase 2's part of is recorded as Leucine-rich repeat, protein family^[19].
Leucine-rich repeat kinase 2's part of is recorded as Serine/threonine-protein kinase, active site, protein family^[20].
Leucine-rich repeat kinase 2's has part is recorded as C-terminal of Roc (COR) domain^[21].
Leucine-rich repeat kinase 2's has part is recorded as Leucine-rich repeat^[22].
Leucine-rich repeat kinase 2's has part is recorded as Roc domain^[23].
Leucine-rich repeat kinase 2's has part is recorded as leucine-rich repeat, typical subtype^[24].
Leucine-rich repeat kinase 2's has part is recorded as serine/threonine-protein kinase, active site^[25].
Leucine-rich repeat kinase 2's has part is recorded as protein kinase, ATP binding site^[26].

⭐ Popularity Graph

0/100 long tail

Quick Facts

Instance of protein

Subclass of protein

Part of WD40/YVTN repeat-like-containing domain superfamily, Protein kinase-like domain superfamily, Armadillo-like helical, Ankyrin repeat-containing domain superfamily, P-loop containing nucleoside triphosphate hydrolase, Armadillo-type fold, Leucine-rich repeat domain superfamily, WD40-repeat-containing domain superfamily, C-terminal of Roc (COR) domain, protein family, Roc domain, protein family, Protein kinase domain, protein family, Small GTP-binding protein domain family, Leucine-rich repeat, typical subtype, protein family, Protein kinase, ATP binding site, protein family, Leucine-rich repeat, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process positive regulation of protein phosphorylation, positive regulation of canonical Wnt signaling pathway, regulation of dopamine receptor signaling pathway, regulation of neuron maturation, regulation of membrane potential, positive regulation of programmed cell death, regulation of synaptic vesicle transport, negative regulation of protein binding, regulation of mitochondrial depolarization, negative regulation of GTPase activity, neuromuscular junction development, exploration behavior, regulation of synaptic transmission, glutamatergic, intracellular distribution of mitochondria, regulation of dendritic spine morphogenesis, mitochondrion localization, regulation of locomotion, response to oxidative stress, reactive oxygen species metabolic process, excitatory postsynaptic potential, cellular response to manganese ion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of neuron death, negative regulation of protein phosphorylation, cell differentiation, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, neuron projection morphogenesis, Golgi organization, determination of adult lifespan, positive regulation of autophagy, phosphorylation, regulation of canonical Wnt signaling pathway, cellular response to organic cyclic compound, positive regulation of dopamine receptor signaling pathway, regulation of protein kinase A signaling, locomotory exploration behavior, synaptic vesicle recycling, regulation of autophagy, regulation of neuroblast proliferation, regulation of branching morphogenesis of a nerve, negative regulation of protein targeting to mitochondrion, olfactory bulb development, positive regulation of protein binding, negative regulation of hydrogen peroxide-induced cell death, peptidyl-threonine phosphorylation, positive regulation of protein ubiquitination, neuron death, intracellular signal transduction, endocytosis, negative regulation of macroautophagy, regulation of kidney size, cellular response to dopamine, cellular response to starvation, negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation, negative regulation of excitatory postsynaptic potential, positive regulation of protein autoubiquitination, MAPK cascade, autophagy, tangential migration from the subventricular zone to the olfactory bulb, peptidyl-serine phosphorylation, regulation of neuron death, cellular response to oxidative stress, negative regulation of protein processing, regulation of synaptic vesicle exocytosis, lysosome organization, GTP metabolic process, positive regulation of GTPase activity, regulation of lysosomal lumen pH, Wnt signalosome assembly, mitochondrion organization, calcium-mediated signaling, negative regulation of autophagosome assembly, regulation of retrograde transport, endosome to Golgi, regulation of CAMKK-AMPK signaling cascade, protein autophosphorylation, protein phosphorylation, positive regulation of histone deacetylase activity, spermatogenesis, regulation of gene expression, striatum development, negative regulation of neuron projection development, positive regulation of nitric-oxide synthase biosynthetic process, neuron projection arborization, positive regulation of synaptic vesicle endocytosis, positive regulation of microglial cell activation, endoplasmic reticulum organization, regulation of protein stability, regulation of ER to Golgi vesicle-mediated transport, regulation of dendritic spine morphogenesis, protein localization to endoplasmic reticulum exit site, regulation of synaptic vesicle endocytosis, regulation of synaptic vesicle transport, regulation of protein stability, protein import into nucleus

Cell component cytoplasm, endosome, multivesicular body, internal vesicle, trans-Golgi network, mitochondrion, neuron projection, dendrite cytoplasm, cell projection, mitochondrial membranes, synaptic vesicle, microvillus, mitochondrial outer membrane, terminal bouton, endoplasmic reticulum, cytoplasmic side of mitochondrial outer membrane, membrane raft, lysosome, perikaryon, growth cone, plasma membrane, axon, soma, mitochondrial matrix, amphisome, inclusion body, synaptic vesicle membrane, Golgi-associated vesicle, cell junction, dendrite, mitochondrial inner membrane, cytoplasmic vesicle, autolysosome, Golgi apparatus, postsynapse, intracellular anatomical structure, Wnt signalosome, cytosol, caveola neck, nucleus, intracellular membrane-bounded organelle, membrane, synapse, ribonucleoprotein complex, lysosome, endosome, endoplasmic reticulum, Golgi apparatus, plasma membrane, mitochondrial membranes, neuron projection, membrane raft, endoplasmic reticulum exit site, glutamatergic synapse, presynaptic cytosol

Encoded by Lrrk2

Found in taxon house mouse

Has part(s) C-terminal of Roc (COR) domain, Leucine-rich repeat, Roc domain, leucine-rich repeat, typical subtype, serine/threonine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain, small GTP-binding protein domain

Imported from wholeness_audit_2026-05-02

Molecular function peroxidase inhibitor activity, transmembrane transporter binding, GTPase activator activity, clathrin binding, kinase activity, tubulin binding, ATP binding, protein kinase activity, syntaxin-1 binding, GTPase activity, SNARE binding, transferase activity, protein homodimerization activity, nucleotide binding, protein kinase A binding, beta-catenin destruction complex binding, actin binding, signaling receptor complex adaptor activity, MAP kinase kinase activity, signal transducer activity, identical protein binding, GTP binding, GTP-dependent protein kinase activity, protein binding, protein serine/threonine kinase activity, protein-containing complex binding, magnesium ion binding, protein serine/threonine kinase activity, magnesium ion binding

External References (3)

Ensembl protein id ENSMUSP00000052584

Refseq protein id NP_080006, XP_006521340, XP_036015439

Uniprot protein id Q5S006

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Leucine-rich repeat kinase 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Leucine-rich repeat kinase 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Leucine-rich repeat kinase 2 — UniProt protein ID (P352): Q5S006. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Leucine-rich repeat kinase 2 — part of (P361): WD40/YVTN repeat-like-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Leucine-rich repeat kinase 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Leucine-rich repeat kinase 2 — part of (P361): Armadillo-like helical. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Leucine-rich repeat kinase 2 — part of (P361): Ankyrin repeat-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Leucine-rich repeat kinase 2 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Leucine-rich repeat kinase 2 — part of (P361): Armadillo-type fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Leucine-rich repeat kinase 2 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Leucine-rich repeat kinase 2 — part of (P361): WD40-repeat-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Leucine-rich repeat kinase 2 — part of (P361): C-terminal of Roc (COR) domain, protein family. wikidata.org.
[14] ↑ Leucine-rich repeat kinase 2 — part of (P361): Roc domain, protein family. wikidata.org.
[15] ↑ Leucine-rich repeat kinase 2 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[16] ↑ Leucine-rich repeat kinase 2 — part of (P361): Small GTP-binding protein domain family. wikidata.org.
[17] ↑ Leucine-rich repeat kinase 2 — part of (P361): Leucine-rich repeat, typical subtype, protein family. wikidata.org.
[18] ↑ Leucine-rich repeat kinase 2 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[19] ↑ Leucine-rich repeat kinase 2 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[20] ↑ Leucine-rich repeat kinase 2 — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[21] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): C-terminal of Roc (COR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): Roc domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): leucine-rich repeat, typical subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Leucine-rich repeat kinase 2 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Leucine-rich repeat kinase 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Leucine-rich repeat kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q15331171

MLA

“Leucine-rich repeat kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q15331171.

BibTeX

@misc{4ortxyz_leucine-rich-repeat-kinase-2-q15331171_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Leucine-rich repeat kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q15331171}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Leucine-rich repeat kinase 2 — https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q15331171 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q15331171 · Last refreshed: May 3, 2026