Leucine rich repeat kinase 2

mammalian protein found in Homo sapiens

Protein protein Q409961

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Leucine rich repeat kinase 2

Summary

Leucine rich repeat kinase 2 is a protein^[1]. It has Wikipedia articles in 10 language editions, a strong signal of global cultural recognition.^[2]

Key Facts

Leucine rich repeat kinase 2's instance of is recorded as protein^[3].
Leucine rich repeat kinase 2 is part of WD40/YVTN repeat-like-containing domain superfamily^[4].
Leucine rich repeat kinase 2 is part of Protein kinase-like domain superfamily^[5].
Leucine rich repeat kinase 2 is part of Armadillo-like helical^[6].
Leucine rich repeat kinase 2 is part of Ankyrin repeat-containing domain superfamily^[7].
Leucine rich repeat kinase 2 is part of P-loop containing nucleoside triphosphate hydrolase^[8].
Leucine rich repeat kinase 2 is part of Armadillo-type fold^[9].
Leucine rich repeat kinase 2 is part of Leucine-rich repeat domain superfamily^[10].
Leucine rich repeat kinase 2 is part of WD40-repeat-containing domain superfamily^[11].
Leucine rich repeat kinase 2 is part of C-terminal of Roc (COR) domain, protein family^[12].
Leucine rich repeat kinase 2 is part of Roc domain, protein family^[13].
Leucine rich repeat kinase 2 is part of Protein kinase domain, protein family^[14].
Leucine rich repeat kinase 2 is part of Small GTP-binding protein domain family^[15].
Leucine rich repeat kinase 2 is part of Leucine-rich repeat, typical subtype, protein family^[16].
Leucine rich repeat kinase 2 is part of Protein kinase, ATP binding site, protein family^[17].
Leucine rich repeat kinase 2 is part of Leucine-rich repeat, protein family^[18].
Leucine rich repeat kinase 2 is part of Serine/threonine-protein kinase, active site, protein family^[19].
Leucine rich repeat kinase 2 comprises leucine-rich repeat, typical subtype^[20].
Leucine rich repeat kinase 2 comprises C-terminal of Roc (COR) domain^[21].
Leucine rich repeat kinase 2 comprises Roc domain^[22].
Leucine rich repeat kinase 2 comprises protein kinase, ATP binding site^[23].
Leucine rich repeat kinase 2 comprises serine/threonine-protein kinase, active site^[24].
Leucine rich repeat kinase 2 comprises small GTP-binding protein domain^[25].
Leucine rich repeat kinase 2 comprises Leucine-rich repeat^[26].
Leucine rich repeat kinase 2 comprises protein kinase domain^[27].

Why It Matters

Leucine rich repeat kinase 2 has Wikipedia articles in 10 language editions, a strong signal of global cultural recognition.^[2] It is known by 8 alternative names across languages and contexts.^[28]

⭐ Popularity Graph

3/100 established

🌐 Wiki Languages

13 / 423 langs

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Quick Facts

Instance of protein

Part of WD40/YVTN repeat-like-containing domain superfamily, Protein kinase-like domain superfamily, Armadillo-like helical, Ankyrin repeat-containing domain superfamily, P-loop containing nucleoside triphosphate hydrolase, Armadillo-type fold, Leucine-rich repeat domain superfamily, WD40-repeat-containing domain superfamily, C-terminal of Roc (COR) domain, protein family, Roc domain, protein family, Protein kinase domain, protein family, Small GTP-binding protein domain family, Leucine-rich repeat, typical subtype, protein family, Protein kinase, ATP binding site, protein family, Leucine-rich repeat, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process lysosome organization, response to oxidative stress, cellular response to dopamine, regulation of autophagy, positive regulation of autophagy, positive regulation of dopamine receptor signaling pathway, regulation of neuroblast proliferation, intracellular distribution of mitochondria, negative regulation of protein processing, negative regulation of protein processing involved in protein targeting to mitochondrion, protein localization to mitochondrion, positive regulation of canonical Wnt signaling pathway, autophagy, neuromuscular junction development, phosphorylation, positive regulation of protein binding, regulation of branching morphogenesis of a nerve, mitochondrion localization, positive regulation of protein autoubiquitination, regulation of synaptic vesicle transport, positive regulation of protein phosphorylation, regulation of kidney size, regulation of synaptic vesicle exocytosis, positive regulation of MAP kinase activity, peptidyl-threonine phosphorylation, MAPK cascade, Wnt signalosome assembly, protein phosphorylation, regulation of synaptic transmission, glutamatergic, excitatory postsynaptic potential, negative regulation of hydrogen peroxide-induced cell death, regulation of dopamine receptor signaling pathway, regulation of membrane potential, protein autophosphorylation, regulation of mitochondrial fission, regulation of neuron maturation, reactive oxygen species metabolic process, positive regulation of programmed cell death, regulation of neuron death, regulation of mitochondrial depolarization, cellular response to oxidative stress, negative regulation of late endosome to lysosome transport, intracellular signal transduction, regulation of lysosomal lumen pH, negative regulation of GTPase activity, locomotory exploration behavior, Golgi organization, canonical Wnt signaling pathway, neuron projection morphogenesis, positive regulation of protein ubiquitination, regulation of canonical Wnt signaling pathway, exploration behavior, cellular response to organic cyclic compound, tangential migration from the subventricular zone to the olfactory bulb, regulation of protein kinase A signaling, calcium-mediated signaling, negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of neuron death, negative regulation of protein targeting to mitochondrion, peptidyl-serine phosphorylation, determination of adult lifespan, negative regulation of excitatory postsynaptic potential, negative regulation of protein phosphorylation, neuron death, GTP metabolic process, negative regulation of autophagosome assembly, olfactory bulb development, cellular response to starvation, regulation of dendritic spine morphogenesis, cell differentiation, endocytosis, negative regulation of protein binding, mitochondrion organization, cellular response to manganese ion, negative regulation of macroautophagy, regulation of locomotion, positive regulation of GTPase activity, regulation of retrograde transport, endosome to Golgi, regulation of CAMKK-AMPK signaling cascade, positive regulation of histone deacetylase activity, mitochondrion organization, endoplasmic reticulum organization, spermatogenesis, regulation of gene expression, negative regulation of neuron projection development, calcium-mediated signaling, striatum development, regulation of protein stability, positive regulation of nitric-oxide synthase biosynthetic process, regulation of ER to Golgi vesicle-mediated transport, regulation of dendritic spine morphogenesis, protein localization to endoplasmic reticulum exit site, neuron projection arborization, regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle endocytosis, regulation of synaptic vesicle transport, negative regulation of autophagosome assembly, positive regulation of microglial cell activation, regulation of retrograde transport, endosome to Golgi, protein import into nucleus

Cell component cytoplasmic vesicle, endosome, extracellular exosome, Wnt signalosome, soma, trans-Golgi network, mitochondrial membranes, synapse, cytoplasm, mitochondrial outer membrane, synaptic vesicle membrane, perikaryon, endoplasmic reticulum, plasma membrane, microvillus, mitochondrial matrix, dendrite cytoplasm, growth cone, cell projection, dendrite, lysosome, neuron projection, Golgi-associated vesicle, mitochondrion, mitochondrial inner membrane, autolysosome, terminal bouton, intracellular anatomical structure, membrane, membrane raft, axon, amphisome, multivesicular body, internal vesicle, synaptic vesicle, inclusion body, cell junction, cytoplasmic side of mitochondrial outer membrane, cytosol, Golgi apparatus, postsynapse, extracellular space, nucleus, intracellular membrane-bounded organelle, caveola neck, extracellular space, cytoplasm, lysosome, endosome, endoplasmic reticulum, Golgi apparatus, cytosol, plasma membrane, mitochondrial membranes, neuron projection, soma, membrane raft, extracellular exosome, endoplasmic reticulum exit site, glutamatergic synapse, presynaptic cytosol, ribonucleoprotein complex

Ec enzyme number 2.7.11.1

Encoded by LRRK2

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) leucine-rich repeat, typical subtype, C-terminal of Roc (COR) domain, Roc domain, protein kinase, ATP binding site, serine/threonine-protein kinase, active site, small GTP-binding protein domain, Leucine-rich repeat, protein kinase domain

Molecular function protein homodimerization activity, signaling receptor complex adaptor activity, clathrin binding, co-receptor binding, transferase activity, GTPase activator activity, protein kinase activity, protein kinase A binding, peroxidase inhibitor activity, SNARE binding, nucleotide binding, identical protein binding, GTPase activity, syntaxin-1 binding, protein serine/threonine kinase activity, tubulin binding, transmembrane transporter binding, microtubule binding, MAP kinase kinase activity, GTP binding, ATP binding, GTP-dependent protein kinase activity, beta-catenin destruction complex binding, protein binding, kinase activity, actin binding, magnesium ion binding, protein serine/threonine kinase activity

External References (7)

Ensembl protein id ENSP00000298910, ENSP00000341930, ENSP00000398726, ENSP00000410821, ENSP00000490200, ENSP00000493752

Freebase id /m/03cp2n2

Microsoft academic id (discontinued) 2780427247

Openalex id C2780427247

Pdb structure id 2ZEJ, 3D6T

Refseq protein id NP_940980, XP_005268686, XP_011536179, XP_011536183, XP_011536184, XP_016874275, XP_016874276, XP_016874277, XP_016874278, XP_024304601

Uniprot protein id Q5S007

🌐 Available in 10 languages

enLRRK2 deSerin/Threoninkinase LRRK2 faLRRK2 fiLRRK2 itDardarina jaLRRK2 koLRRK2 ptLRRK2 ukLRRK2 zhLRRK2

🏷️ Also known as

en leucine-rich repeat serine/threonine-protein kinase 2 en LRRK2 en augmented in rheumatoid arthritis 17 en Dardarin de Dardarin de LRRK2 es LRRK2 zh 震顫素

🔗 Connections

Cell component 35

mitochondrion, nucleus, cytoplasm, cytoplasm, plasma membrane, plasma membrane, endoplasmic reticulum, endoplasmic reticulum +27 more

Biological process 8

autophagy, cell differentiation, endocytosis, spermatogenesis, phosphorylation, regulation of gene expression, excitatory postsynaptic potential, protein phosphorylation

Found in taxon 1

Homo sapiens

Instance of 1

protein

Molecular function 1

protein binding

Part of 1

Leucine-rich repeat, protein family

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Leucine rich repeat kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/leucine-rich-repeat-kinase-2

MLA

“Leucine rich repeat kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/leucine-rich-repeat-kinase-2.

BibTeX

@misc{4ortxyz_leucine-rich-repeat-kinase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Leucine rich repeat kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/leucine-rich-repeat-kinase-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Leucine rich repeat kinase 2 — https://4ort.xyz/entity/leucine-rich-repeat-kinase-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/leucine-rich-repeat-kinase-2 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5d ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Instance of → —

Part of → —

Encoded by → LRRK2

Biological process → lysosome organization, response to oxidative stress, cellular response to dopamine +99

+ 9 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

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Leucine rich repeat kinase 2

Leucine rich repeat kinase 2

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

Aggregate / graph-position facts

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