Leigh disease

mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity
MedicalCondition rare_disease Q1815019
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Leigh disease

Summary

Leigh disease is a rare disease[1]. It draws 367 Wikipedia views per month (rare_disease category, ranking #94 of 627).[2]

Key Facts

  • Leigh disease's instance of is recorded as rare disease[3].
  • Leigh disease's instance of is recorded as class of disease[4].
  • Leigh disease is a type of mitochondrial disease[5].
  • Leigh disease is a type of disease[6].
  • Leigh disease's Commons category is recorded as Leigh syndrome[7].
  • Leigh disease's symptoms and signs is recorded as vomiting[8].
  • Leigh disease's NCI Thesaurus ID is recorded as C84814[9].
  • Leigh disease's health specialty is recorded as neurology[10].
  • Leigh disease's genetic association is recorded as NDUFS8[11].
  • Leigh disease's genetic association is recorded as NDUFA9[12].
  • Leigh disease's genetic association is recorded as NDUFA12[13].
  • Leigh disease's genetic association is recorded as BCS1L[14].
  • Leigh disease's genetic association is recorded as NDUFA2[15].
  • Leigh disease's genetic association is recorded as COX15[16].
  • Leigh disease's genetic association is recorded as NDUFS3[17].
  • Leigh disease's genetic association is recorded as NDUFS7[18].
  • Leigh disease's genetic association is recorded as SDHA[19].
  • Leigh disease's genetic association is recorded as NDUFS4[20].
  • Leigh disease's genetic association is recorded as SURF1[21].
  • Leigh disease's exact match is recorded as http://purl.obolibrary.org/obo/DOID_3652[22].
  • Leigh disease's exact match is recorded as http://identifiers.org/doid/DOID:3652[23].
  • Leigh disease's exact match is recorded as http://www.orpha.net/ORDO/Orphanet_506[24].
  • Leigh disease's on focus list of Wikimedia project is recorded as WikiProject Medicine[25].

Why It Matters

Leigh disease draws 367 Wikipedia views per month (rare_disease category, ranking #94 of 627).[2] It has Wikipedia articles in 14 language editions, a strong signal of global cultural recognition.[26] It is known by 21 alternative names across languages and contexts.[27]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . wikidata.org.
  2. [4] . wikidata.org.
  3. [5] . Disease Ontology. Retrieved . wikidata.org.
  4. [6] . wikidata.org.
  5. [7] . wikidata.org.
  6. [8] . Disease Ontology. Retrieved . wikidata.org.
  7. [9] . Disease Ontology. Retrieved . wikidata.org.
  8. [10] . wikidata.org.
  9. [11] . Q905695. wikidata.org.
  10. [12] . Defective NDUFA9 as a novel cause of neonatally fatal complex I disease. wikidata.org.
  11. [13] . Respiratory chain complex I deficiency due to NDUFA12 mutations as a new cause of Leigh syndrome. wikidata.org.
  12. [14] . A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure.. wikidata.org.
  13. [15] . NDUFA2 complex I mutation leads to Leigh disease. wikidata.org.
  14. [16] . Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome. wikidata.org.
  15. [17] . Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome. wikidata.org.
  16. [18] . Human mitochondrial complex I in health and disease. wikidata.org.
  17. [19] . Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. wikidata.org.
  18. [20] . A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome. wikidata.org.
  19. [21] . SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. wikidata.org.
  20. [22] . Disease Ontology. Retrieved . wikidata.org.
  21. [23] . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.
  22. [24] . wikidata.org.
  23. [25] . wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [26] . Wikidata sitelinks. wikidata.org.
  3. [27] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Leigh disease. Retrieved May 3, 2026, from https://4ort.xyz/entity/leigh-disease
MLA “Leigh disease.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/leigh-disease.
BibTeX @misc{4ortxyz_leigh-disease_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Leigh disease}}, year = {2026}, url = {https://4ort.xyz/entity/leigh-disease}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Leigh disease — https://4ort.xyz/entity/leigh-disease (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/leigh-disease · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 14d ago · Twofivesixbot bot · 2026-05-18 view diff on Wikidata ↗
    Instance of
    Genetic association NDUFS8, NDUFA9, NDUFA12 +8
    Health specialty neurology
    Aliases
    + 5 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update-qualifiers:1||1|11 */ [[Property:P2347]]: 39105, mv to monolingual text names on YSO statements"
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