LCK proto-oncogene, Src family tyrosine kinase

mammalian protein found in Homo sapiens

Protein protein Q9020944

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LCK proto-oncogene, Src family tyrosine kinase

Summary

LCK proto-oncogene, Src family tyrosine kinase is a protein^[1].

Key Facts

LCK proto-oncogene, Src family tyrosine kinase's instance of is recorded as protein^[2].
LCK proto-oncogene, Src family tyrosine kinase's physically interacts with is recorded as saracatinib^[3].
LCK proto-oncogene, Src family tyrosine kinase's physically interacts with is recorded as SU6656^[4].
LCK proto-oncogene, Src family tyrosine kinase is part of SH3-like domain superfamily^[5].
LCK proto-oncogene, Src family tyrosine kinase is part of Protein kinase-like domain superfamily^[6].
LCK proto-oncogene, Src family tyrosine kinase is part of SH2 domain superfamily^[7].
LCK proto-oncogene, Src family tyrosine kinase is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[8].
LCK proto-oncogene, Src family tyrosine kinase is part of SH2 domain, protein family^[9].
LCK proto-oncogene, Src family tyrosine kinase is part of SH3 domain, protein family^[10].
LCK proto-oncogene, Src family tyrosine kinase is part of Protein kinase domain, protein family^[11].
LCK proto-oncogene, Src family tyrosine kinase is part of Tyrosine-protein kinase Lck, SH2 domain, protein family^[12].
LCK proto-oncogene, Src family tyrosine kinase is part of Protein kinase, ATP binding site, protein family^[13].
LCK proto-oncogene, Src family tyrosine kinase is part of Tyrosine-protein kinase, catalytic domain, protein family^[14].
LCK proto-oncogene, Src family tyrosine kinase is part of Tyrosine-protein kinase, active site, protein family^[15].
LCK proto-oncogene, Src family tyrosine kinase is part of Lck, SH3 domain, protein family^[16].
LCK proto-oncogene, Src family tyrosine kinase comprises tyrosine-protein kinase, active site^[17].
LCK proto-oncogene, Src family tyrosine kinase comprises SH3 domain^[18].
LCK proto-oncogene, Src family tyrosine kinase comprises protein kinase, ATP binding site^[19].
LCK proto-oncogene, Src family tyrosine kinase comprises protein kinase domain^[20].
LCK proto-oncogene, Src family tyrosine kinase comprises tyrosine-protein kinase, catalytic domain^[21].
LCK proto-oncogene, Src family tyrosine kinase comprises SH2 domain^[22].
LCK proto-oncogene, Src family tyrosine kinase comprises serine-threonine/tyrosine-protein kinase, catalytic domain^[23].
LCK proto-oncogene, Src family tyrosine kinase comprises Tyrosine-protein kinase Lck, SH2 domain^[24].
LCK proto-oncogene, Src family tyrosine kinase comprises Lck, SH3 domain^[25].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of SH3-like domain superfamily, Protein kinase-like domain superfamily, SH2 domain superfamily, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Tyrosine-protein kinase Lck, SH2 domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Lck, SH3 domain, protein family

Properties

Biological process B cell receptor signaling pathway, release of sequestered calcium ion into cytosol, hemopoiesis, phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of T cell receptor signaling pathway, T cell costimulation, mitigation of host defenses by virus, platelet activation, T cell differentiation, regulation of cell population proliferation, cellular zinc ion homeostasis, regulation of lymphocyte activation, peptidyl-tyrosine autophosphorylation, T cell receptor signaling pathway, positive regulation of intrinsic apoptotic signaling pathway, leukocyte migration, positive regulation of T cell activation, protein dephosphorylation, innate immune response, phosphatidylinositol phosphate biosynthetic process, viral process, protein phosphorylation, activation of cysteine-type endopeptidase activity involved in apoptotic process, cell migration, peptidyl-tyrosine phosphorylation, interleukin-7-mediated signaling pathway, positive regulation of protein kinase B signaling, cell differentiation, T cell differentiation, positive regulation of heterotypic cell-cell adhesion, positive regulation of leukocyte cell-cell adhesion, cellular zinc ion homeostasis, activation of cysteine-type endopeptidase activity involved in apoptotic process, T cell differentiation, positive regulation of T cell activation, positive regulation of intrinsic apoptotic signaling pathway

Cell component cytoplasm, cytosol, membrane, extrinsic component of cytoplasmic side of plasma membrane, immunological synapse, extracellular exosome, pericentriolar material, membrane raft, plasma membrane, extracellular exosome, pericentriolar material, membrane raft

Ec enzyme number 2.7.10.2

Encoded by LCK

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, SH3 domain, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, SH2 domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Tyrosine-protein kinase Lck, SH2 domain, Lck, SH3 domain

Molecular function transferase activity, nucleotide binding, protein kinase activity, CD4 receptor binding, ATPase binding, SH2 domain binding, CD8 receptor binding, phosphatidylinositol 3-kinase binding, protein C-terminus binding, protein binding, identical protein binding, protein phosphatase binding, ATP binding, protein kinase binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, kinase activity, protein serine/threonine phosphatase activity, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity, T cell receptor binding, signaling receptor binding, protein tyrosine kinase activity, protein serine/threonine phosphatase activity, kinase activity, SH2 domain binding

Physically interacts with saracatinib, SU6656

External References (6)

Ensembl protein id ENSP00000328213, ENSP00000337825, ENSP00000477713, ENSP00000362658, ENSP00000362663, ENSP00000362665, ENSP00000431517, ENSP00000434525, ENSP00000435605, ENSP00000436554

Mesh descriptor id D019860

Mesh tree code D08.811.913.696.620.682.725.800.315, D12.776.476.568.800.315, D12.776.624.664.700.128

Pdb structure id 1BHF, 1BHH, 1CWD, 1CWE, 1FBZ, 1H92, 1IJR, 1KIK, 1LCJ, 1LCK, 1LKK, 1LKL, 1Q68, 1Q69, 1QPC, 1QPD, 1QPE, 1QPJ, 1X27, 2IIM, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2PL0, 2ZM1, 2ZM4, 2ZYB, 3AC1, 3AC2, 3AC3, 3AC4, 3AC5, 3AC8, 3ACJ, 3ACK, 3AD4, 3AD5, 3AD6, 3B2W, 3BRH, 3BYM, 3BYO, 3BYS, 3BYU, 3KMM, 3KXZ, 3LCK, 3MPM, 4D8K, 4C3F

Refseq protein id NP_001036236, NP_001317397, NP_005347, XP_011539755, XP_024302814, XP_024302815

Uniprot protein id P06239, E9PI33

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ LCK proto-oncogene, Src family tyrosine kinase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ LCK proto-oncogene, Src family tyrosine kinase — physically interacts with (P129): saracatinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ LCK proto-oncogene, Src family tyrosine kinase — physically interacts with (P129): SU6656. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[9] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): SH2 domain, protein family. wikidata.org.
[10] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): SH3 domain, protein family. wikidata.org.
[11] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[12] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Tyrosine-protein kinase Lck, SH2 domain, protein family. wikidata.org.
[13] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[14] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[15] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[16] ↑ LCK proto-oncogene, Src family tyrosine kinase — part of (P361): Lck, SH3 domain, protein family. wikidata.org.
[17] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): Tyrosine-protein kinase Lck, SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ LCK proto-oncogene, Src family tyrosine kinase — has part(s) (P527): Lck, SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ LCK proto-oncogene, Src family tyrosine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). LCK proto-oncogene, Src family tyrosine kinase. Retrieved May 3, 2026, from https://4ort.xyz/entity/lck-proto-oncogene-src-family-tyrosine-kinase-q9020944

MLA

“LCK proto-oncogene, Src family tyrosine kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lck-proto-oncogene-src-family-tyrosine-kinase-q9020944.

BibTeX

@misc{4ortxyz_lck-proto-oncogene-src-family-tyrosine-kinase-q9020944_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{LCK proto-oncogene, Src family tyrosine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/lck-proto-oncogene-src-family-tyrosine-kinase-q9020944}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): LCK proto-oncogene, Src family tyrosine kinase — https://4ort.xyz/entity/lck-proto-oncogene-src-family-tyrosine-kinase-q9020944 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/lck-proto-oncogene-src-family-tyrosine-kinase-q9020944 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

10d ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P06239, E9PI33

Imported from → —

Mesh descriptor id → D019860

Ensembl protein id → ENSP00000328213, ENSP00000337825, ENSP00000477713 +7

+ 15 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.2, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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