Klotho

mammalian protein found in Homo sapiens
Protein protein Q414050
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Klotho

Summary

Klotho is a protein[1]. Klotho draws 499 Wikipedia views per month (protein category, ranking #105 of 987).[2]

Key Facts

  • Klotho's instance of is recorded as protein[3].
  • Klotho is a type of membrane protein[4].
  • Klotho is part of Klotho[5].
  • Klotho is part of glycoside hydrolase superfamily[6].
  • Klotho is part of auxiliary protein involved in transmembrane transport[7].
  • Klotho is part of Glycosyl hydrolases family 1, N-terminal conserved site, protein family[8].
  • Klotho comprises Glycosyl hydrolases family 1, N-terminal conserved site[9].
  • Klotho's molecular function is recorded as hydrolase activity, hydrolyzing O-glycosyl compounds[10].
  • Klotho's molecular function is recorded as hormone activity[11].
  • Klotho's molecular function is recorded as beta-glucuronidase activity[12].
  • Klotho's molecular function is recorded as signal transducer activity[13].
  • Klotho's molecular function is recorded as hydrolase activity, acting on glycosyl bonds[14].
  • Klotho's molecular function is recorded as vitamin D binding[15].
  • Klotho's molecular function is recorded as fibroblast growth factor binding[16].
  • Klotho's molecular function is recorded as beta-glucosidase activity[17].
  • Klotho's molecular function is recorded as hydrolase activity[18].
  • Klotho's molecular function is recorded as phosphatidylinositol-4,5-bisphosphate 3-kinase activity[19].
  • Klotho's molecular function is recorded as fibroblast growth factor receptor binding[20].
  • Klotho's molecular function is recorded as 1-phosphatidylinositol-3-kinase activity[21].
  • Klotho's molecular function is recorded as beta-glucosidase activity[22].
  • Klotho's molecular function is recorded as fibroblast growth factor binding[23].
  • Klotho's cell component is recorded as integral component of membrane[24].
  • Klotho's cell component is recorded as membrane[25].
  • Klotho's cell component is recorded as plasma membrane[26].
  • Klotho's cell component is recorded as integral component of plasma membrane[27].

Why It Matters

Klotho draws 499 Wikipedia views per month (protein category, ranking #105 of 987).[2] Klotho has Wikipedia articles in 11 language editions, a strong signal of global cultural recognition.[28] Klotho is known by 7 alternative names across languages and contexts.[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] . Retrieved . wikidata.org.
  6. [8] . wikidata.org.
  7. [9] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . Association of human aging with a functional variant of klotho. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . Identification of the HumanKlothoGene and Its Two Transcripts Encoding Membrane and SecretedKlothoProtein. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata sitelinks. wikidata.org.
  3. [29] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Klotho. Retrieved May 3, 2026, from https://4ort.xyz/entity/klotho
MLA “Klotho.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/klotho.
BibTeX @misc{4ortxyz_klotho_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Klotho}}, year = {2026}, url = {https://4ort.xyz/entity/klotho}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Klotho — https://4ort.xyz/entity/klotho (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/klotho · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Instance of
    Part of
    Subclass of membrane protein
    Encoded by KL
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.2.1.31, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"
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