Interleukin 4

mammalian protein found in Mus musculus
Thing general Q14865947
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Interleukin 4

Summary

Key Facts

  • Interleukin 4's Commons category is recorded as Interleukin-4 (IL-4)[1].
  • Interleukin 4 comprises Interleukin-4/interleukin-13, conserved site[2].
  • Interleukin 4's HomoloGene ID is recorded as 491[3].
  • Interleukin 4's genomic start is recorded as 132673986[4].
  • Interleukin 4's genomic start is recorded as 132009678[5].
  • Interleukin 4's genomic end is recorded as 132018368[6].
  • Interleukin 4's genomic end is recorded as 132682678[7].
  • Interleukin 4's biological process is recorded as extrinsic apoptotic signaling pathway in absence of ligand[8].
  • Interleukin 4's biological process is recorded as regulation of immune response[9].
  • Interleukin 4's biological process is recorded as positive regulation of peptidyl-tyrosine phosphorylation[10].
  • Interleukin 4's biological process is recorded as positive regulation of B cell activation[11].
  • Interleukin 4's biological process is recorded as positive regulation of isotype switching to IgG isotypes[12].
  • Interleukin 4's biological process is recorded as negative regulation of T cell activation[13].
  • Interleukin 4's biological process is recorded as negative regulation of T-helper 17 cell differentiation[14].
  • Interleukin 4's biological process is recorded as positive regulation of transcription by RNA polymerase II[15].
  • Interleukin 4's biological process is recorded as positive regulation of activated T cell proliferation[16].
  • Interleukin 4's biological process is recorded as defense response to protozoan[17].
  • Interleukin 4's biological process is recorded as positive regulation of tyrosine phosphorylation of STAT protein[18].
  • Interleukin 4's biological process is recorded as regulation of signaling receptor activity[19].
  • Interleukin 4's biological process is recorded as negative regulation of epithelial cell migration[20].
  • Interleukin 4's biological process is recorded as positive regulation of interleukin-13 production[21].
  • Interleukin 4's biological process is recorded as T-helper 2 cell cytokine production[22].
  • Interleukin 4's biological process is recorded as myeloid dendritic cell differentiation[23].
  • Interleukin 4's biological process is recorded as positive regulation of T cell differentiation[24].
  • Interleukin 4's biological process is recorded as negative regulation of transcription, DNA-templated[25].

Body

Use and Application

Interleukin 4 comprises Interleukin-4/interleukin-13, conserved site[2].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] . wikidata.org.
  2. [2] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] . Q20641742. Retrieved . wikidata.org.
  4. [4] . ensembl Release 106. wikidata.org.
  5. [5] . ensembl Release 106. wikidata.org.
  6. [6] . ensembl Release 106. wikidata.org.
  7. [7] . ensembl Release 106. wikidata.org.
  8. [8] . The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [9] . T-bet regulates T-independent IgG2a class switching. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [10] . Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [11] . Expressed genes in interleukin-4 treated Bcellsidentified by cDNA representational differenceanalysis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] . Impaired IgA class switching in APRIL-deficient mice. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] . IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] . Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] . Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] . Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] . Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] . Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Interleukin 4. Retrieved May 7, 2026, from https://4ort.xyz/entity/interleukin-4-q14865947
MLA “Interleukin 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 7 May. 2026, https://4ort.xyz/entity/interleukin-4-q14865947.
BibTeX @misc{4ortxyz_interleukin-4-q14865947_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Interleukin 4}}, year = {2026}, url = {https://4ort.xyz/entity/interleukin-4-q14865947}, note = {Accessed: 2026-05-07}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Interleukin 4 — https://4ort.xyz/entity/interleukin-4-q14865947 (retrieved 2026-05-07)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 5d ago · Twofivesixbot bot · 2026-05-31 view diff on Wikidata ↗
    Nalt id 47508
    Expressed in oocyte, secondary oocyte, right uterine tube +7
    Freebase id /m/025s20t
    Encoded by Il4
    + 24 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update-qualifiers:1||1|2 */ [[Property:P8189]]: 987007536902705171, mv to monolingual text names on J9U statements"
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