High mobility group box 1

mammalian protein found in Rattus norvegicus

Protein protein Q28560462

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High mobility group box 1

Summary

High mobility group box 1 is a protein^[1].

Key Facts

High mobility group box 1's instance of is recorded as protein^[2].
High mobility group box 1's UniProt protein ID is recorded as P63159^[3].
High mobility group box 1's part of is recorded as High mobility group box domain superfamily^[4].
High mobility group box 1's part of is recorded as membrane protein^[5].
High mobility group box 1's part of is recorded as High mobility group box domain, protein family^[6].
High mobility group box 1's part of is recorded as HMG box A DNA-binding domain, conserved site, protein family^[7].
High mobility group box 1's has part is recorded as High mobility group box domain^[8].
High mobility group box 1's has part is recorded as HMG box A DNA-binding domain, conserved site^[9].
High mobility group box 1's RefSeq protein ID is recorded as NP_037095^[10].
High mobility group box 1's RefSeq protein ID is recorded as XP_038945039^[11].
High mobility group box 1's RefSeq protein ID is recorded as XP_038945040^[12].
High mobility group box 1's molecular function is recorded as four-way junction DNA binding^[13].
High mobility group box 1's molecular function is recorded as open form four-way junction DNA binding^[14].
High mobility group box 1's molecular function is recorded as crossed form four-way junction DNA binding^[15].
High mobility group box 1's molecular function is recorded as bubble DNA binding^[16].
High mobility group box 1's molecular function is recorded as DNA binding^[17].
High mobility group box 1's molecular function is recorded as bent DNA binding^[18].
High mobility group box 1's molecular function is recorded as double-stranded DNA binding^[19].
High mobility group box 1's molecular function is recorded as single-stranded DNA binding^[20].
High mobility group box 1's molecular function is recorded as cytokine activity^[21].
High mobility group box 1's molecular function is recorded as protein binding^[22].
High mobility group box 1's molecular function is recorded as 5S rRNA binding^[23].
High mobility group box 1's molecular function is recorded as transcription factor binding^[24].
High mobility group box 1's molecular function is recorded as heparin binding^[25].
High mobility group box 1's molecular function is recorded as DNA binding, bending^[26].

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Quick Facts

Instance of protein

Part of High mobility group box domain superfamily, membrane protein, High mobility group box domain, protein family, HMG box A DNA-binding domain, conserved site, protein family

Properties

Biological process cell morphogenesis, positive regulation of mesenchymal cell proliferation, activation of innate immune response, adaptive immune response, immune system process, regulation of T cell mediated immune response to tumor cell, DNA repair, DNA recombination, chromatin remodeling, regulation of transcription by RNA polymerase II, autophagy, chemotaxis, inflammatory response, cellular response to DNA damage stimulus, nervous system development, circadian rhythm, negative regulation of DNA replication, positive regulation of cell population proliferation, response to heat, response to glucose, regulation of signaling receptor activity, positive regulation of autophagy, positive regulation of cell death, positive regulation of neuron projection development, positive regulation of smooth muscle cell migration, positive regulation of cell migration, neuron projection development, actin cytoskeleton reorganization, DNA geometric change, response to lipopolysaccharide, developmental process, positive regulation of interleukin-1 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of tumor necrosis factor production, response to insulin, positive regulation of myeloid cell apoptotic process, positive regulation of toll-like receptor 9 signaling pathway, response to interferon-gamma, positive regulation of apoptotic process, apoptotic cell clearance, innate immune response, positive regulation of innate immune response, positive regulation of myoblast differentiation, positive regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, regulation of inflammatory response, male-specific defense response to bacterium, induction of positive chemotaxis, positive regulation of DNA ligation, myoblast proliferation, cell chemotaxis, positive regulation of ERK1 and ERK2 cascade, cellular response to interleukin-1, positive regulation of macrophage inflammatory protein 1 alpha production, neutrophil clearance, positive regulation of NIK/NF-kappaB signaling, signal transduction

Cell component extracellular region, extracellular space, nucleus, chromosome, cytoplasm, endosome, endoplasmic reticulum-Golgi intermediate compartment, cytosol, plasma membrane, membrane, membrane raft

Encoded by Hmgb1

Found in taxon brown rat

Has part(s) High mobility group box domain, HMG box A DNA-binding domain, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function four-way junction DNA binding, open form four-way junction DNA binding, crossed form four-way junction DNA binding, bubble DNA binding, DNA binding, bent DNA binding, double-stranded DNA binding, single-stranded DNA binding, cytokine activity, protein binding, 5S rRNA binding, transcription factor binding, heparin binding, DNA binding, bending, peptide binding, protein dimerization activity, RAGE receptor binding, glycolipid binding, supercoiled DNA binding

External References (3)

Ensembl protein id ENSRNOP00000069851

Refseq protein id NP_037095, XP_038945039, XP_038945040

Uniprot protein id P63159

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ High mobility group box 1 — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ High mobility group box 1 — UniProt protein ID (P352): P63159. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ High mobility group box 1 — part of (P361): High mobility group box domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ High mobility group box 1 — part of (P361): membrane protein. wikidata.org.
[6] ↑ High mobility group box 1 — part of (P361): High mobility group box domain, protein family. wikidata.org.
[7] ↑ High mobility group box 1 — part of (P361): HMG box A DNA-binding domain, conserved site, protein family. wikidata.org.
[8] ↑ High mobility group box 1 — has part(s) (P527): High mobility group box domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ High mobility group box 1 — has part(s) (P527): HMG box A DNA-binding domain, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ High mobility group box 1 — RefSeq protein ID (P637): NP_037095. Q20641742. Retrieved 2021-09-07. wikidata.org.
[11] ↑ High mobility group box 1 — RefSeq protein ID (P637): XP_038945039. Q20641742. Retrieved 2021-09-07. wikidata.org.
[12] ↑ High mobility group box 1 — RefSeq protein ID (P637): XP_038945040. Q20641742. Retrieved 2021-09-07. wikidata.org.
[13] ↑ High mobility group box 1 — molecular function (P680): four-way junction DNA binding. The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ High mobility group box 1 — molecular function (P680): open form four-way junction DNA binding. A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ High mobility group box 1 — molecular function (P680): crossed form four-way junction DNA binding. A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ High mobility group box 1 — molecular function (P680): bubble DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ High mobility group box 1 — molecular function (P680): DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ High mobility group box 1 — molecular function (P680): bent DNA binding. A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ High mobility group box 1 — molecular function (P680): double-stranded DNA binding. DNA binding by single HMG box model proteins. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ High mobility group box 1 — molecular function (P680): single-stranded DNA binding. DNA binding by single HMG box model proteins. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ High mobility group box 1 — molecular function (P680): cytokine activity. Recombinant HMGB1 with cytokine-stimulating activity. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ High mobility group box 1 — molecular function (P680): protein binding. Borna Disease Virus Phosphoprotein Represses p53-Mediated Transcriptional Activity by Interference with HMGB1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ High mobility group box 1 — molecular function (P680): 5S rRNA binding. Interactions of recombinant HMGB proteins with branched RNA substrates. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ High mobility group box 1 — molecular function (P680): transcription factor binding. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ High mobility group box 1 — molecular function (P680): heparin binding. 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ High mobility group box 1 — molecular function (P680): DNA binding, bending. HMGB binding to DNA: single and double box motifs. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ High mobility group box 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). High mobility group box 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/high-mobility-group-box-1-q28560462

MLA

“High mobility group box 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/high-mobility-group-box-1-q28560462.

BibTeX

@misc{4ortxyz_high-mobility-group-box-1-q28560462_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{High mobility group box 1}}, year = {2026}, url = {https://4ort.xyz/entity/high-mobility-group-box-1-q28560462}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): High mobility group box 1 — https://4ort.xyz/entity/high-mobility-group-box-1-q28560462 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/high-mobility-group-box-1-q28560462 · Last refreshed: May 3, 2026