High mobility group AT-hook 2

mammalian protein found in Homo sapiens

Protein protein Q5630986

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High mobility group AT-hook 2

Summary

High mobility group AT-hook 2 is a protein^[1].

Key Facts

High mobility group AT-hook 2's instance of is recorded as protein^[2].
High mobility group AT-hook 2's UniProt protein ID is recorded as P52926^[3].
High mobility group AT-hook 2's part of is recorded as hgh mobility group protein HMGA^[4].
High mobility group AT-hook 2's part of is recorded as AT hook, DNA-binding motif, protein family^[5].
High mobility group AT-hook 2's part of is recorded as HMG-I/HMG-Y, DNA-binding, conserved site, protein family^[6].
High mobility group AT-hook 2's MeSH descriptor ID is recorded as D025743^[7].
High mobility group AT-hook 2's has part is recorded as AT hook, DNA-binding motif^[8].
High mobility group AT-hook 2's has part is recorded as HMG-I/HMG-Y, DNA-binding, conserved site^[9].
High mobility group AT-hook 2's RefSeq protein ID is recorded as NP_001287847^[10].
High mobility group AT-hook 2's RefSeq protein ID is recorded as NP_001287848^[11].
High mobility group AT-hook 2's RefSeq protein ID is recorded as NP_001317119^[12].
High mobility group AT-hook 2's RefSeq protein ID is recorded as NP_003474^[13].
High mobility group AT-hook 2's RefSeq protein ID is recorded as NP_003475^[14].
High mobility group AT-hook 2's MeSH tree code is recorded as D12.776.260.312.937^[15].
High mobility group AT-hook 2's MeSH tree code is recorded as D12.776.660.235.400.500.600^[16].
High mobility group AT-hook 2's MeSH tree code is recorded as D12.776.664.235.400.500.600^[17].
High mobility group AT-hook 2's molecular function is recorded as DNA binding^[18].
High mobility group AT-hook 2's molecular function is recorded as DNA-dependent protein kinase activity^[19].
High mobility group AT-hook 2's molecular function is recorded as MH1 domain binding^[20].
High mobility group AT-hook 2's molecular function is recorded as 5'-deoxyribose-5-phosphate lyase activity^[21].
High mobility group AT-hook 2's molecular function is recorded as minor groove of adenine-thymine-rich DNA binding^[22].
High mobility group AT-hook 2's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[23].
High mobility group AT-hook 2's molecular function is recorded as transcription factor binding^[24].
High mobility group AT-hook 2's molecular function is recorded as C2H2 zinc finger domain binding^[25].
High mobility group AT-hook 2's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Part of hgh mobility group protein HMGA, AT hook, DNA-binding motif, protein family, HMG-I/HMG-Y, DNA-binding, conserved site, protein family

Properties

Biological process positive regulation of transcription by RNA polymerase II, positive regulation of transcription regulatory region DNA binding, regulation of cell cycle process, regulation of transcription, DNA-templated, endodermal cell differentiation, chondrocyte differentiation, regulation of cellular response to drug, negative regulation of DNA binding, response to virus, regulation of stem cell population maintenance, negative regulation of apoptotic process, positive regulation of cellular response to X-ray, negative regulation of transcription by RNA polymerase II, chromatin organization, heterochromatin assembly, oncogene-induced cell senescence, stem cell differentiation, transcription, DNA-templated, multicellular organism development, positive regulation of transcription, DNA-templated, negative regulation by host of viral transcription, cell division, positive regulation of gene expression, mesenchymal cell differentiation, chromosome condensation, negative regulation of double-strand break repair via nonhomologous end joining, chondrocyte proliferation, positive regulation of cellular senescence, positive regulation of response to DNA damage stimulus, epithelial to mesenchymal transition, positive regulation of apoptotic process, mesodermal cell differentiation, regulation of growth, cell cycle, mitotic G2 DNA damage checkpoint signaling, negative regulation of transcription, DNA-templated, positive regulation of stem cell proliferation, fat cell differentiation, chromosome breakage, mesodermal-endodermal cell signaling, base-excision repair, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, transcription by RNA polymerase II, positive regulation of angiogenesis, positive regulation of cell proliferation in bone marrow, negative regulation of cellular senescence, base-excision repair, regulation of transcription, DNA-templated, negative regulation of DNA binding, positive regulation of protein serine/threonine kinase activity

Cell component SMAD protein complex, senescence-associated heterochromatin focus, nuclear chromosome, protein-DNA complex, chromatin, nucleus, nucleoplasm, nucleus

Encoded by HMGA2

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) AT hook, DNA-binding motif, HMG-I/HMG-Y, DNA-binding, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, DNA-dependent protein kinase activity, MH1 domain binding, 5'-deoxyribose-5-phosphate lyase activity, minor groove of adenine-thymine-rich DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, C2H2 zinc finger domain binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, MH2 domain binding, protein binding, DNA-(apurinic or apyrimidinic site) endonuclease activity, nucleosomal DNA binding, DNA binding, bending, SMAD binding, cAMP response element binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coregulator activity, DNA-(apurinic or apyrimidinic site) endonuclease activity

External References (6)

Ensembl protein id ENSP00000443372, ENSP00000346658, ENSP00000377206, ENSP00000384026, ENSP00000407306, ENSP00000437747, ENSP00000377205, ENSP00000437621, ENSP00000439317, ENSP00000440919

Mesh descriptor id D025743

Mesh tree code D12.776.260.312.937, D12.776.660.235.400.500.600, D12.776.664.235.400.500.600

Refseq protein id NP_001287847, NP_001287848, NP_001317119, NP_003474, NP_003475

Umls cui C0122111

Uniprot protein id P52926

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ High mobility group AT-hook 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ High mobility group AT-hook 2 — UniProt protein ID (P352): P52926. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ High mobility group AT-hook 2 — part of (P361): hgh mobility group protein HMGA. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ High mobility group AT-hook 2 — part of (P361): AT hook, DNA-binding motif, protein family. wikidata.org.
[6] ↑ High mobility group AT-hook 2 — part of (P361): HMG-I/HMG-Y, DNA-binding, conserved site, protein family. wikidata.org.
[7] ↑ High mobility group AT-hook 2 — MeSH descriptor ID (P486): D025743. wikidata.org.
[8] ↑ High mobility group AT-hook 2 — has part(s) (P527): AT hook, DNA-binding motif. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ High mobility group AT-hook 2 — has part(s) (P527): HMG-I/HMG-Y, DNA-binding, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ High mobility group AT-hook 2 — RefSeq protein ID (P637): NP_001287847. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ High mobility group AT-hook 2 — RefSeq protein ID (P637): NP_001287848. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ High mobility group AT-hook 2 — RefSeq protein ID (P637): NP_001317119. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ High mobility group AT-hook 2 — RefSeq protein ID (P637): NP_003474. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ High mobility group AT-hook 2 — RefSeq protein ID (P637): NP_003475. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ High mobility group AT-hook 2 — MeSH tree code (P672): D12.776.260.312.937. wikidata.org.
[16] ↑ High mobility group AT-hook 2 — MeSH tree code (P672): D12.776.660.235.400.500.600. wikidata.org.
[17] ↑ High mobility group AT-hook 2 — MeSH tree code (P672): D12.776.664.235.400.500.600. wikidata.org.
[18] ↑ High mobility group AT-hook 2 — molecular function (P680): DNA binding. Expression and cDNA cloning of human HMGI-C phosphoprotein. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ High mobility group AT-hook 2 — molecular function (P680): DNA-dependent protein kinase activity. Suppression of nonhomologous end joining repair by overexpression of HMGA2. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ High mobility group AT-hook 2 — molecular function (P680): MH1 domain binding. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ High mobility group AT-hook 2 — molecular function (P680): 5'-deoxyribose-5-phosphate lyase activity. HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ High mobility group AT-hook 2 — molecular function (P680): minor groove of adenine-thymine-rich DNA binding. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ High mobility group AT-hook 2 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ High mobility group AT-hook 2 — molecular function (P680): transcription factor binding. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ High mobility group AT-hook 2 — molecular function (P680): C2H2 zinc finger domain binding. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ High mobility group AT-hook 2 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ High mobility group AT-hook 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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MLA

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BibTeX

@misc{4ortxyz_high-mobility-group-at-hook-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{High mobility group AT-hook 2}}, year = {2026}, url = {https://4ort.xyz/entity/high-mobility-group-at-hook-2}, note = {Accessed: 2026-05-03}}

LLM prompt

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