CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

mammalian protein found in Mus musculus

Protein protein Q21428393

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CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Summary

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) is a protein^[1].

Key Facts

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s instance of is recorded as protein^[2].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s UniProt protein ID is recorded as P04441^[3].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as Thyroglobulin type-1 superfamily^[4].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as MHC class II-associated invariant chain, trimerisation domain superfamily^[5].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as MHC class II-associated invariant chain^[6].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as membrane protein^[7].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as MHC class II-associated invariant chain, trimerisation, protein family^[8].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as Thyroglobulin type-1, protein family^[9].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s part of is recorded as MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family^[10].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s has part is recorded as MHC class II-associated invariant chain, trimerisation^[11].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s has part is recorded as MHC class II-associated invariant chain/CLIP, MHC II-interacting^[12].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s has part is recorded as Thyroglobulin type-1^[13].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s RefSeq protein ID is recorded as NP_001036070^[14].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s RefSeq protein ID is recorded as NP_034675^[15].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as MHC class II protein binding^[16].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as nitric-oxide synthase binding^[17].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as protein folding chaperone activity^[18].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as amyloid-beta binding^[19].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as macrophage migration inhibitory factor binding^[20].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as protein binding^[21].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as MHC class II protein complex binding^[22].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as cytokine receptor activity^[23].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as MHC class II protein binding, via antigen binding groove^[24].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as cytokine binding^[25].
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)'s molecular function is recorded as CD4 receptor binding^[26].

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Quick Facts

Instance of protein

Part of Thyroglobulin type-1 superfamily, MHC class II-associated invariant chain, trimerisation domain superfamily, MHC class II-associated invariant chain, membrane protein, MHC class II-associated invariant chain, trimerisation, protein family, Thyroglobulin type-1, protein family, MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family

Properties

Biological process positive regulation of T cell differentiation, defense response, antigen processing and presentation, adaptive immune response, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, antigen processing and presentation of exogenous peptide antigen via MHC class II, positive regulation of cytokine-mediated signaling pathway, negative regulation of peptide secretion, positive regulation of adaptive immune response, macrophage migration inhibitory factor signaling pathway, positive regulation of macrophage cytokine production, positive regulation of chemokine (C-X-C motif) ligand 2 production, immune system process, positive regulation of fibroblast proliferation, negative regulation of apoptotic process, negative regulation of mature B cell apoptotic process, chaperone cofactor-dependent protein refolding, negative thymic T cell selection, positive regulation of dendritic cell antigen processing and presentation, negative regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of B cell proliferation, immunoglobulin mediated immune response, immune response, positive thymic T cell selection, positive regulation of ERK1 and ERK2 cascade, positive regulation of innate immune response, positive regulation of neutrophil chemotaxis, positive regulation of peptidyl-tyrosine phosphorylation, prostaglandin biosynthetic process, cell population proliferation, positive regulation of type 2 immune response, intracellular protein transport, negative regulation of T cell differentiation, signal transduction, positive regulation of protein phosphorylation, positive regulation of kinase activity, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of MAPK cascade, positive regulation of monocyte differentiation, positive regulation of transcription, DNA-templated, positive regulation of viral entry into host cell, protein heterotetramerization, protein trimerization, protein-containing complex assembly

Cell component integral component of membrane, multivesicular body, late endosome, Golgi apparatus, macrophage migration inhibitory factor receptor complex, plasma membrane, NOS2-CD74 complex, integral component of plasma membrane, MHC class II protein complex, cell surface, vacuole, endoplasmic reticulum, lysosome, external side of plasma membrane, membrane

Encoded by Cd74

Found in taxon house mouse

Has part(s) MHC class II-associated invariant chain, trimerisation, MHC class II-associated invariant chain/CLIP, MHC II-interacting, Thyroglobulin type-1

Imported from wholeness_audit_2026-05-02

Molecular function MHC class II protein binding, nitric-oxide synthase binding, protein folding chaperone activity, amyloid-beta binding, macrophage migration inhibitory factor binding, protein binding, MHC class II protein complex binding, cytokine receptor activity, MHC class II protein binding, via antigen binding groove, cytokine binding, CD4 receptor binding

External References (3)

Ensembl protein id ENSMUSP00000057836, ENSMUSP00000095171, ENSMUSP00000126688

Refseq protein id NP_001036070, NP_034675

Uniprot protein id P04441

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — UniProt protein ID (P352): P04441. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): Thyroglobulin type-1 superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): MHC class II-associated invariant chain, trimerisation domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): MHC class II-associated invariant chain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): membrane protein. wikidata.org.
[8] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): MHC class II-associated invariant chain, trimerisation, protein family. wikidata.org.
[9] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): Thyroglobulin type-1, protein family. wikidata.org.
[10] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — part of (P361): MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family. wikidata.org.
[11] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — has part(s) (P527): MHC class II-associated invariant chain, trimerisation. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — has part(s) (P527): MHC class II-associated invariant chain/CLIP, MHC II-interacting. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — has part(s) (P527): Thyroglobulin type-1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — RefSeq protein ID (P637): NP_001036070. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — RefSeq protein ID (P637): NP_034675. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): MHC class II protein binding. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): nitric-oxide synthase binding. Nitric-oxide synthase 2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): protein folding chaperone activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): amyloid-beta binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): macrophage migration inhibitory factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): protein binding. CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): MHC class II protein complex binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): cytokine receptor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): MHC class II protein binding, via antigen binding groove. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): cytokine binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — molecular function (P680): CD4 receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_cd74-antigen-invariant-polypeptide-of-major-histocompatibility-complex-class-ii-antigen-associated-_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)}}, year = {2026}, url = {https://4ort.xyz/entity/cd74-antigen-invariant-polypeptide-of-major-histocompatibility-complex-class-ii-antigen-associated-}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) — https://4ort.xyz/entity/cd74-antigen-invariant-polypeptide-of-major-histocompatibility-complex-class-ii-antigen-associated- (retrieved 2026-05-03)

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