Caveolin 1

mammalian protein found in Homo sapiens

Protein protein Q21115385

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Caveolin 1

Summary

Caveolin 1 is a protein^[1].

Key Facts

Caveolin 1's instance of is recorded as protein^[2].
Caveolin 1's UniProt protein ID is recorded as Q03135^[3].
Caveolin 1's part of is recorded as caveolin-1^[4].
Caveolin 1's part of is recorded as auxiliary protein involved in transmembrane transport^[5].
Caveolin 1's part of is recorded as Caveolin, conserved site, protein family^[6].
Caveolin 1's has part is recorded as Caveolin, conserved site^[7].
Caveolin 1's RefSeq protein ID is recorded as NP_001166366^[8].
Caveolin 1's RefSeq protein ID is recorded as NP_001166367^[9].
Caveolin 1's RefSeq protein ID is recorded as NP_001166368^[10].
Caveolin 1's RefSeq protein ID is recorded as NP_001744^[11].
Caveolin 1's molecular function is recorded as protein-macromolecule adaptor activity^[12].
Caveolin 1's molecular function is recorded as transmembrane transporter binding^[13].
Caveolin 1's molecular function is recorded as structural molecule activity^[14].
Caveolin 1's molecular function is recorded as signaling receptor binding^[15].
Caveolin 1's molecular function is recorded as nitric-oxide synthase binding^[16].
Caveolin 1's molecular function is recorded as patched binding^[17].
Caveolin 1's molecular function is recorded as enzyme binding^[18].
Caveolin 1's molecular function is recorded as peptidase activator activity^[19].
Caveolin 1's molecular function is recorded as protein binding^[20].
Caveolin 1's molecular function is recorded as molecular adaptor activity^[21].
Caveolin 1's molecular function is recorded as protein kinase binding^[22].
Caveolin 1's molecular function is recorded as ATPase binding^[23].
Caveolin 1's molecular function is recorded as cholesterol binding^[24].
Caveolin 1's molecular function is recorded as inward rectifier potassium channel inhibitor activity^[25].
Caveolin 1's molecular function is recorded as identical protein binding^[26].

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Quick Facts

Instance of protein

Part of caveolin-1, auxiliary protein involved in transmembrane transport, Caveolin, conserved site, protein family

Properties

Biological process caveolin-mediated endocytosis, positive regulation of calcium ion transport into cytosol, vasoconstriction, response to progesterone, negative regulation of protein binding, regulation of peptidase activity, protein localization to plasma membrane raft, mammary gland development, vasculogenesis, negative regulation of pinocytosis, response to ischemia, angiogenesis, apoptotic signaling pathway, positive regulation of extrinsic apoptotic signaling pathway, cholesterol homeostasis, triglyceride metabolic process, negative regulation of canonical Wnt signaling pathway, calcium ion transport, negative regulation of cell population proliferation, cellular response to transforming growth factor beta stimulus, positive regulation of toll-like receptor 3 signaling pathway, regulation of cytosolic calcium ion concentration, regulation of smooth muscle contraction, vesicle organization, negative regulation of peptidyl-tyrosine autophosphorylation, regulation of cardiac muscle cell action potential involved in regulation of contraction, negative regulation of transforming growth factor beta receptor signaling pathway, protein localization to basolateral plasma membrane, receptor internalization involved in canonical Wnt signaling pathway, regulation of membrane repolarization during action potential, positive regulation of peptidyl-serine phosphorylation, negative regulation of protein tyrosine kinase activity, regulation of entry of bacterium into host cell, negative regulation of MAP kinase activity, positive regulation of vasoconstriction, negative regulation of potassium ion transmembrane transport, lactation, receptor-mediated endocytosis of virus by host cell, regulation of blood coagulation, regulation of ventricular cardiac muscle cell action potential, protein homooligomerization, viral process, positive regulation of intrinsic apoptotic signaling pathway, negative regulation of receptor signaling pathway via JAK-STAT, mammary gland involution, calcium ion homeostasis, negative regulation of necroptotic process, regulation of the force of heart contraction, lipid storage, nitric oxide homeostasis, membrane depolarization, negative regulation of cytokine-mediated signaling pathway, cellular calcium ion homeostasis, negative regulation of transcription by RNA polymerase II, response to estrogen, response to calcium ion, regulation of fatty acid metabolic process, cellular response to exogenous dsRNA, negative regulation of MAPK cascade, regulation of ruffle assembly, positive regulation of protein binding, positive regulation of protein ubiquitination, negative regulation of anoikis, leukocyte migration, protein localization, positive regulation of cell adhesion molecule production, response to hypoxia, negative regulation of nitric-oxide synthase activity, response to bacterium, caveola assembly, cellular response to hyperoxia, cholesterol transport, cellular response to starvation, T cell costimulation, regulation of nitric-oxide synthase activity, receptor internalization, positive regulation of peptidase activity, positive regulation of ER-associated ubiquitin-dependent protein catabolic process, negative regulation of endothelial cell proliferation, negative regulation of BMP signaling pathway, negative regulation of protein ubiquitination, cellular response to peptide hormone stimulus, positive regulation of gene expression, negative regulation of nitric oxide biosynthetic process, angiotensin-activated signaling pathway involved in heart process, protein complex oligomerization, negative regulation of peptidyl-serine phosphorylation, posttranscriptional regulation of gene expression, positive regulation of gap junction assembly, maintenance of protein location in cell, negative regulation of signal transduction, regulation of the force of heart contraction by chemical signal, regulation of cell communication by electrical coupling involved in cardiac conduction, regulation of heart rate by cardiac conduction, negative regulation of epithelial cell differentiation, skeletal muscle tissue development, beta-catenin destruction complex disassembly, positive regulation of catalytic activity, positive regulation of canonical Wnt signaling pathway, negative regulation of tyrosine phosphorylation of STAT protein, negative regulation of inward rectifier potassium channel activity, negative regulation of endothelial cell proliferation, cellular calcium ion homeostasis, cell differentiation, positive regulation of cell migration, negative regulation of protein tyrosine kinase activity, caveola assembly, positive regulation of cold-induced thermogenesis, positive regulation of NF-kappaB transcription factor activity

Cell component endocytic vesicle membrane, endosome, membrane, focal adhesion, VCP-NPL4-UFD1 AAA ATPase complex, perinuclear region of cytoplasm, caveola, cilium, apical plasma membrane, endoplasmic reticulum, membrane raft, integral component of membrane, Golgi apparatus, early endosome membrane, plasma membrane, intracellular anatomical structure, cell cortex, endoplasmic reticulum membrane, Golgi membrane, integral component of plasma membrane, acrosomal membrane, basolateral plasma membrane, cytoplasmic vesicle, lipid droplet, cytoplasm, Golgi apparatus, integral component of plasma membrane, caveola, focal adhesion, cytoplasmic vesicle, protein-containing complex, sarcolemma, perinuclear region of cytoplasm

Encoded by CAV1

Found in taxon Homo sapiens

Has part(s) Caveolin, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function protein-macromolecule adaptor activity, transmembrane transporter binding, structural molecule activity, signaling receptor binding, nitric-oxide synthase binding, patched binding, enzyme binding, peptidase activator activity, protein binding, molecular adaptor activity, protein kinase binding, ATPase binding, cholesterol binding, inward rectifier potassium channel inhibitor activity, identical protein binding, protein heterodimerization activity, structural molecule activity, protein kinase binding, molecular adaptor activity, transmembrane transporter binding, structural molecule activity, protein-containing complex binding

External References (4)

Ensembl protein id ENSP00000339191, ENSP00000377110, ENSP00000377111, ENSP00000384348, ENSP00000479447, ENSP00000377113, ENSP00000389033, ENSP00000409541

Refseq protein id NP_001166366, NP_001166367, NP_001166368, NP_001744

Transporter classification database id 8.A.26.1.1

Uniprot protein id Q03135

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Caveolin 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Caveolin 1 — UniProt protein ID (P352): Q03135. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Caveolin 1 — part of (P361): caveolin-1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Caveolin 1 — part of (P361): auxiliary protein involved in transmembrane transport. Retrieved 2019-10-02. wikidata.org.
[6] ↑ Caveolin 1 — part of (P361): Caveolin, conserved site, protein family. wikidata.org.
[7] ↑ Caveolin 1 — has part(s) (P527): Caveolin, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Caveolin 1 — RefSeq protein ID (P637): NP_001166366. Q20641742. Retrieved 2020-05-30. wikidata.org.
[9] ↑ Caveolin 1 — RefSeq protein ID (P637): NP_001166367. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ Caveolin 1 — RefSeq protein ID (P637): NP_001166368. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Caveolin 1 — RefSeq protein ID (P637): NP_001744. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Caveolin 1 — molecular function (P680): protein-macromolecule adaptor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Caveolin 1 — molecular function (P680): transmembrane transporter binding. The regulation of the cardiac potassium channel (HERG) by caveolin-1. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Caveolin 1 — molecular function (P680): structural molecule activity. Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Caveolin 1 — molecular function (P680): signaling receptor binding. Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Caveolin 1 — molecular function (P680): nitric-oxide synthase binding. Caveolae and caveolin-1 in human term villous trophoblast. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Caveolin 1 — molecular function (P680): patched binding. The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Caveolin 1 — molecular function (P680): enzyme binding. The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Caveolin 1 — molecular function (P680): peptidase activator activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Caveolin 1 — molecular function (P680): protein binding. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Caveolin 1 — molecular function (P680): molecular adaptor activity. Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Caveolin 1 — molecular function (P680): protein kinase binding. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Caveolin 1 — molecular function (P680): ATPase binding. Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Caveolin 1 — molecular function (P680): cholesterol binding. BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Caveolin 1 — molecular function (P680): inward rectifier potassium channel inhibitor activity. The regulation of the cardiac potassium channel (HERG) by caveolin-1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Caveolin 1 — molecular function (P680): identical protein binding. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Caveolin 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Caveolin 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/caveolin-1

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BibTeX

@misc{4ortxyz_caveolin-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Caveolin 1}}, year = {2026}, url = {https://4ort.xyz/entity/caveolin-1}, note = {Accessed: 2026-05-03}}

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