C-X3-C motif chemokine ligand 1

mammalian protein found in Homo sapiens

Protein protein Q2743450

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C-X3-C motif chemokine ligand 1

Summary

C-X3-C motif chemokine ligand 1 is a protein^[1].

Key Facts

C-X3-C motif chemokine ligand 1's instance of is recorded as protein^[2].
C-X3-C motif chemokine ligand 1's UniProt protein ID is recorded as P78423^[3].
C-X3-C motif chemokine ligand 1's part of is recorded as Chemokine interleukin-8-like superfamily^[4].
C-X3-C motif chemokine ligand 1's part of is recorded as fractalkine^[5].
C-X3-C motif chemokine ligand 1's part of is recorded as Chemokine interleukin-8-like domain, protein family^[6].
C-X3-C motif chemokine ligand 1's part of is recorded as CX3C chemokine domain, protein family^[7].
C-X3-C motif chemokine ligand 1's has part is recorded as Chemokine interleukin-8-like domain^[8].
C-X3-C motif chemokine ligand 1's has part is recorded as CX3C chemokine domain^[9].
C-X3-C motif chemokine ligand 1's RefSeq protein ID is recorded as NP_001291321^[10].
C-X3-C motif chemokine ligand 1's RefSeq protein ID is recorded as NP_002987^[11].
C-X3-C motif chemokine ligand 1's PDB structure ID is recorded as 1B2T^[12].
C-X3-C motif chemokine ligand 1's PDB structure ID is recorded as 1F2L^[13].
C-X3-C motif chemokine ligand 1's PDB structure ID is recorded as 3ONA^[14].
C-X3-C motif chemokine ligand 1's PDB structure ID is recorded as 4XT1^[15].
C-X3-C motif chemokine ligand 1's PDB structure ID is recorded as 4XT3^[16].
C-X3-C motif chemokine ligand 1's Freebase ID is recorded as /m/027dtfq^[17].
C-X3-C motif chemokine ligand 1's molecular function is recorded as cytokine activity^[18].
C-X3-C motif chemokine ligand 1's molecular function is recorded as chemokine activity^[19].
C-X3-C motif chemokine ligand 1's molecular function is recorded as protein binding^[20].
C-X3-C motif chemokine ligand 1's molecular function is recorded as CCR chemokine receptor binding^[21].
C-X3-C motif chemokine ligand 1's molecular function is recorded as signaling receptor binding^[22].
C-X3-C motif chemokine ligand 1's molecular function is recorded as integrin binding^[23].
C-X3-C motif chemokine ligand 1's molecular function is recorded as CX3C chemokine receptor binding^[24].
C-X3-C motif chemokine ligand 1's cell component is recorded as integral component of membrane^[25].
C-X3-C motif chemokine ligand 1's cell component is recorded as membrane^[26].

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Quick Facts

Instance of protein

Part of Chemokine interleukin-8-like superfamily, fractalkine, Chemokine interleukin-8-like domain, protein family, CX3C chemokine domain, protein family

Properties

Biological process G protein-coupled receptor signaling pathway, defense response, positive regulation of inflammatory response, monocyte chemotaxis, cytokine-mediated signaling pathway, chemokine-mediated signaling pathway, angiogenesis involved in wound healing, cellular response to tumor necrosis factor, wound healing, leukocyte chemotaxis, neutrophil chemotaxis, positive regulation of angiogenesis, positive regulation of transforming growth factor beta1 production, positive regulation of GTPase activity, cell adhesion, immune response, cellular response to interleukin-1, leukocyte adhesive activation, positive regulation of ERK1 and ERK2 cascade, cellular response to interferon-gamma, cell chemotaxis, lymphocyte chemotaxis, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of calcium-independent cell-cell adhesion, chemotaxis, integrin activation, negative regulation of cell migration, leukocyte migration involved in inflammatory response, macrophage chemotaxis, regulation of signaling receptor activity

Cell component integral component of membrane, membrane, plasma membrane, extracellular region, cell surface, extracellular space

Encoded by CX3CL1

Found in taxon Homo sapiens

Has part(s) Chemokine interleukin-8-like domain, CX3C chemokine domain

Imported from wholeness_audit_2026-05-02

Molecular function cytokine activity, chemokine activity, protein binding, CCR chemokine receptor binding, signaling receptor binding, integrin binding, CX3C chemokine receptor binding

External References (5)

Ensembl protein id ENSP00000006053, ENSP00000456830, ENSP00000457996, ENSP00000464114

Freebase id /m/027dtfq

Pdb structure id 1B2T, 1F2L, 3ONA, 4XT1, 4XT3

Refseq protein id NP_001291321, NP_002987

Uniprot protein id P78423

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ C-X3-C motif chemokine ligand 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ C-X3-C motif chemokine ligand 1 — UniProt protein ID (P352): P78423. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ C-X3-C motif chemokine ligand 1 — part of (P361): Chemokine interleukin-8-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ C-X3-C motif chemokine ligand 1 — part of (P361): fractalkine. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ C-X3-C motif chemokine ligand 1 — part of (P361): Chemokine interleukin-8-like domain, protein family. wikidata.org.
[7] ↑ C-X3-C motif chemokine ligand 1 — part of (P361): CX3C chemokine domain, protein family. wikidata.org.
[8] ↑ C-X3-C motif chemokine ligand 1 — has part(s) (P527): Chemokine interleukin-8-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ C-X3-C motif chemokine ligand 1 — has part(s) (P527): CX3C chemokine domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ C-X3-C motif chemokine ligand 1 — RefSeq protein ID (P637): NP_001291321. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ C-X3-C motif chemokine ligand 1 — RefSeq protein ID (P637): NP_002987. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ C-X3-C motif chemokine ligand 1 — PDB structure ID (P638): 1B2T. Q905695. Retrieved 2016-08-04. wikidata.org.
[13] ↑ C-X3-C motif chemokine ligand 1 — PDB structure ID (P638): 1F2L. Q905695. Retrieved 2016-08-04. wikidata.org.
[14] ↑ C-X3-C motif chemokine ligand 1 — PDB structure ID (P638): 3ONA. Q905695. Retrieved 2016-08-04. wikidata.org.
[15] ↑ C-X3-C motif chemokine ligand 1 — PDB structure ID (P638): 4XT1. Q905695. Retrieved 2016-08-04. wikidata.org.
[16] ↑ C-X3-C motif chemokine ligand 1 — PDB structure ID (P638): 4XT3. Q905695. Retrieved 2016-08-04. wikidata.org.
[17] ↑ C-X3-C motif chemokine ligand 1 — Freebase ID (P646): /m/027dtfq. Freebase Data Dumps. wikidata.org.
[18] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): cytokine activity. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): chemokine activity. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): protein binding. Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): CCR chemokine receptor binding. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): signaling receptor binding. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): integrin binding. Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ C-X3-C motif chemokine ligand 1 — molecular function (P680): CX3C chemokine receptor binding. Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ C-X3-C motif chemokine ligand 1 — cell component (P681): integral component of membrane. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ C-X3-C motif chemokine ligand 1 — cell component (P681): membrane. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ C-X3-C motif chemokine ligand 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). C-X3-C motif chemokine ligand 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450

MLA

“C-X3-C motif chemokine ligand 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450.

BibTeX

@misc{4ortxyz_c-x3-c-motif-chemokine-ligand-1-q2743450_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{C-X3-C motif chemokine ligand 1}}, year = {2026}, url = {https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): C-X3-C motif chemokine ligand 1 — https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450 (retrieved 2026-05-03)

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