C-reactive protein
annular pentameric protein found in blood plasma whose circulating concentrations rise in response to inflammation
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Summary
C-reactive protein is a protein[1]. It ranks in the top 0.41% of protein entities by monthly Wikipedia readership (4,297 views/month, #4 of 987).[2]
Key Facts
- Part of: Pentraxin[3], Concanavalin A-like lectin/glucanase domain superfamily[4], Pentraxins[5]
- Has part(s): Pentaxin, conserved site[6]
- Molecular function: low-density lipoprotein particle receptor binding[7], calcium ion binding[8], virion binding[9], complement component C1q complex binding[10], protein binding[11], metal ion binding[12], low-density lipoprotein particle binding[13], choline binding[14], identical protein binding[15]
- Cell component: extracellular region[16], extracellular space[17]
- Biological process: negative regulation of lipid storage[18], positive regulation of superoxide anion generation[19], positive regulation of gene expression[20], inflammatory response[21], acute-phase response[22], negative regulation of macrophage derived foam cell differentiation[23], opsonization[24], defense response to Gram-positive bacterium[25], complement activation, classical pathway[26], innate immune response[27]
- Encoded by: CRP[28]
- Found in taxon: Homo sapiens[29]
- NCI Thesaurus ID: C60651[30]
- Short name: CRP[31]
- Different from: CRP[32], serum C reactive protein level[33]
- Exact match: http://purl.uniprot.org/uniprot/P02741[34]
Why It Matters
C-reactive protein has Wikipedia articles in 27 language editions, a strong signal of global cultural recognition.[35] It is known by 50 alternative names across languages and contexts.[36]