C-reactive protein

annular pentameric protein found in blood plasma whose circulating concentrations rise in response to inflammation
Protein protein Q422766
Press Enter · cited answer in seconds

C-reactive protein

Summary

C-reactive protein is a protein[1]. It ranks in the top 0.41% of protein entities by monthly Wikipedia readership (1,848 views/month, #4 of 987).[2]

Key Facts

  • C-reactive protein's instance of is recorded as protein[3].
  • C-reactive protein is part of Pentraxin[4].
  • C-reactive protein is part of Concanavalin A-like lectin/glucanase domain superfamily[5].
  • C-reactive protein is part of Pentraxins[6].
  • C-reactive protein comprises Pentaxin, conserved site[7].
  • C-reactive protein's molecular function is recorded as low-density lipoprotein particle receptor binding[8].
  • C-reactive protein's molecular function is recorded as calcium ion binding[9].
  • C-reactive protein's molecular function is recorded as virion binding[10].
  • C-reactive protein's molecular function is recorded as complement component C1q complex binding[11].
  • C-reactive protein's molecular function is recorded as protein binding[12].
  • C-reactive protein's molecular function is recorded as metal ion binding[13].
  • C-reactive protein's molecular function is recorded as low-density lipoprotein particle binding[14].
  • C-reactive protein's molecular function is recorded as choline binding[15].
  • C-reactive protein's molecular function is recorded as identical protein binding[16].
  • C-reactive protein's molecular function is recorded as complement component C1q complex binding[17].
  • C-reactive protein's molecular function is recorded as low-density lipoprotein particle binding[18].
  • C-reactive protein's cell component is recorded as extracellular region[19].
  • C-reactive protein's cell component is recorded as extracellular space[20].
  • C-reactive protein's cell component is recorded as extracellular space[21].
  • C-reactive protein's biological process is recorded as negative regulation of lipid storage[22].
  • C-reactive protein's biological process is recorded as positive regulation of superoxide anion generation[23].
  • C-reactive protein's biological process is recorded as positive regulation of gene expression[24].
  • C-reactive protein's biological process is recorded as inflammatory response[25].
  • C-reactive protein's biological process is recorded as acute-phase response[26].
  • C-reactive protein's biological process is recorded as negative regulation of macrophage derived foam cell differentiation[27].

Why It Matters

C-reactive protein ranks in the top 0.41% of protein entities by monthly Wikipedia readership (1,848 views/month, #4 of 987).[2] It has Wikipedia articles in 27 language editions, a strong signal of global cultural recognition.[28] It is known by 26 alternative names across languages and contexts.[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . wikidata.org.
  5. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] . Selective Activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Mediates C-Reactive Protein–Evoked Endothelial Vasodilator Dysfunction in Coronary Arterioles. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] . Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . Targeting C-reactive protein for the treatment of cardiovascular disease.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . The human plasma proteome: a nonredundant list developed by combination of four separate sources. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . Pro/Anti-Inflammatory Cytokines in the Pathogenesis of Premature Coronary Artery Disease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . Selective Activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Mediates C-Reactive Protein–Evoked Endothelial Vasodilator Dysfunction in Coronary Arterioles. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . Selective Activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Mediates C-Reactive Protein–Evoked Endothelial Vasodilator Dysfunction in Coronary Arterioles. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . Regulation of complement activation by C-reactive protein. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata sitelinks. wikidata.org.
  3. [29] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). C-reactive protein. Retrieved May 3, 2026, from https://4ort.xyz/entity/c-reactive-protein
MLA “C-reactive protein.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/c-reactive-protein.
BibTeX @misc{4ortxyz_c-reactive-protein_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{C-reactive protein}}, year = {2026}, url = {https://4ort.xyz/entity/c-reactive-protein}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): C-reactive protein — https://4ort.xyz/entity/c-reactive-protein (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/c-reactive-protein · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 6d ago · Twofivesixbot bot · 2026-05-25 view diff on Wikidata ↗
    Cell component extracellular region, extracellular space, extracellular space
    Part of
    Instance of
    Different from CRP, serum C reactive protein level
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update-qualifiers:1||1|2 */ [[Property:P8189]]: 987007293774005171, mv to monolingual text names on J9U statements"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.