BRAF V600E

genetic variant
Thing missense_mutation Q21851559
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BRAF V600E

Summary

BRAF V600E is a missense mutation[1]. It draws 6 Wikipedia views per month (missense_mutation category, ranking #2 of 1).[2]

Key Facts

  • BRAF V600E's instance of is recorded as missense mutation[3].
  • BRAF V600E's genomic start is recorded as 140453136[4].
  • BRAF V600E's genomic end is recorded as 140453136[5].
  • BRAF V600E's Ensembl transcript ID is recorded as ENST00000288602.6[6].
  • BRAF V600E's chromosome is recorded as human chromosome 7[7].
  • BRAF V600E's ClinVar Variation ID is recorded as 13961[8].
  • BRAF V600E's Google Knowledge Graph ID is recorded as /g/11bx55tm0f[9].
  • BRAF V600E's CIViC variant ID is recorded as 12[10].
  • BRAF V600E's HGVS nomenclature is recorded as NM_004333.4:c.1799T>A[11].
  • BRAF V600E's HGVS nomenclature is recorded as NC_000007.13:g.140453136A>T[12].
  • BRAF V600E's HGVS nomenclature is recorded as NP_004324.2:p.Val600Glu[13].
  • BRAF V600E's HGVS nomenclature is recorded as ENST00000288602.6:c.1799T>A[14].
  • BRAF V600E's positive therapeutic predictor for is recorded as Dabrafenib / Trametinib combination therapy[15].
  • BRAF V600E's positive therapeutic predictor for is recorded as Vemurafenib / Gefitinib / Cetuximab combination therapy[16].
  • BRAF V600E's positive therapeutic predictor for is recorded as Vemurafenib / Panitumumab combination therapy[17].
  • BRAF V600E's positive therapeutic predictor for is recorded as Vemurafenib / Panitumumab combination therapy[18].
  • BRAF V600E's positive therapeutic predictor for is recorded as Dabrafenib / Trametinib combination therapy[19].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[20].
  • BRAF V600E's positive therapeutic predictor for is recorded as pictilisib[21].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[22].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[23].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[24].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[25].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[26].
  • BRAF V600E's positive therapeutic predictor for is recorded as vemurafenib[27].

Why It Matters

BRAF V600E draws 6 Wikipedia views per month (missense_mutation category, ranking #2 of 1).[2]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  2. [4] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  3. [5] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  4. [6] . CIViC database. civic.genome.wustl.edu. Provenance: wikidata.org.
  5. [7] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  6. [8] . ClinGen Allele Registry. Retrieved . reg.clinicalgenome.org. Provenance: wikidata.org.
  7. [9] . wikidata.org.
  8. [10] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  9. [11] . ClinGen Allele Registry. Retrieved . reg.clinicalgenome.org. Provenance: wikidata.org.
  10. [12] . ClinGen Allele Registry. Retrieved . reg.clinicalgenome.org. Provenance: wikidata.org.
  11. [13] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  12. [14] . CIViC database. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  13. [15] . Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  14. [16] . Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  15. [17] . Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  16. [18] . MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer.. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  17. [19] . Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  18. [20] . Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  19. [21] . First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  20. [22] . Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  21. [23] . Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  22. [24] . Improved survival with vemurafenib in melanoma with BRAF V600E mutation. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  23. [25] . Extended Antitumor Responseof a BRAF V600E Papillary Thyroid Carcinoma to Vemurafenib. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  24. [26] . Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.
  25. [27] . Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial. Retrieved . civic.genome.wustl.edu. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). BRAF V600E. Retrieved May 3, 2026, from https://4ort.xyz/entity/braf-v600e
MLA “BRAF V600E.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/braf-v600e.
BibTeX @misc{4ortxyz_braf-v600e_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{BRAF V600E}}, year = {2026}, url = {https://4ort.xyz/entity/braf-v600e}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): BRAF V600E — https://4ort.xyz/entity/braf-v600e (retrieved 2026-05-03)

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