Activating transcription factor 4

mammalian protein found in Rattus norvegicus

Protein protein Q28562744

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Activating transcription factor 4

Summary

Activating transcription factor 4 is a protein^[1].

Key Facts

Activating transcription factor 4's instance of is recorded as protein^[2].
Activating transcription factor 4's UniProt protein ID is recorded as Q9ES19^[3].
Activating transcription factor 4's part of is recorded as cAMP-dependent transcription factor ATF-4^[4].
Activating transcription factor 4's part of is recorded as membrane protein^[5].
Activating transcription factor 4's part of is recorded as Basic-leucine zipper domain, protein family^[6].
Activating transcription factor 4's has part is recorded as Basic-leucine zipper domain^[7].
Activating transcription factor 4's RefSeq protein ID is recorded as NP_077379^[8].
Activating transcription factor 4's RefSeq protein ID is recorded as XP_038935870^[9].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[10].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[11].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[12].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[13].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[14].
Activating transcription factor 4's molecular function is recorded as DNA binding^[15].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity^[16].
Activating transcription factor 4's molecular function is recorded as protein C-terminus binding^[17].
Activating transcription factor 4's molecular function is recorded as transcription factor binding^[18].
Activating transcription factor 4's molecular function is recorded as protein kinase binding^[19].
Activating transcription factor 4's molecular function is recorded as leucine zipper domain binding^[20].
Activating transcription factor 4's molecular function is recorded as sequence-specific DNA binding^[21].
Activating transcription factor 4's cell component is recorded as nucleus^[22].
Activating transcription factor 4's cell component is recorded as transcription regulator complex^[23].
Activating transcription factor 4's cell component is recorded as cytoplasm^[24].
Activating transcription factor 4's cell component is recorded as centrosome^[25].
Activating transcription factor 4's cell component is recorded as microtubule organizing center^[26].

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Quick Facts

Instance of protein

Part of cAMP-dependent transcription factor ATF-4, membrane protein, Basic-leucine zipper domain, protein family

Properties

Biological process gluconeogenesis, regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II, cellular calcium ion homeostasis, gamma-aminobutyric acid signaling pathway, circadian rhythm, response to toxic substance, positive regulation of vascular endothelial growth factor production, positive regulation of gene expression, neuron differentiation, negative regulation of translational initiation in response to stress, circadian regulation of gene expression, cellular response to amino acid starvation, cellular response to UV, response to endoplasmic reticulum stress, positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress, PERK-mediated unfolded protein response, cellular response to glucose starvation, mRNA transcription by RNA polymerase II, negative regulation of potassium ion transport, positive regulation of neuron apoptotic process, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, rhythmic process, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, positive regulation of biomineral tissue development, cellular response to oxygen-glucose deprivation, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron death, cellular response to dopamine, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, positive regulation of sodium-dependent phosphate transport

Cell component nucleus, transcription regulator complex, cytoplasm, centrosome, microtubule organizing center, cytoskeleton, plasma membrane, membrane, dendrite membrane, protein-containing complex, nuclear periphery, neuron projection, RNA polymerase II transcription regulator complex, Lewy body core, ATF4-CREB1 transcription factor complex, ATF1-ATF4 transcription factor complex, CHOP-ATF4 complex

Encoded by Atf4

Found in taxon brown rat

Has part(s) Basic-leucine zipper domain

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA binding, DNA-binding transcription factor activity, protein C-terminus binding, transcription factor binding, protein kinase binding, leucine zipper domain binding, sequence-specific DNA binding

External References (3)

Ensembl protein id ENSRNOP00000060302

Refseq protein id NP_077379, XP_038935870

Uniprot protein id Q9ES19

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Activating transcription factor 4 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Activating transcription factor 4 — UniProt protein ID (P352): Q9ES19. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Activating transcription factor 4 — part of (P361): cAMP-dependent transcription factor ATF-4. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Activating transcription factor 4 — part of (P361): membrane protein. wikidata.org.
[6] ↑ Activating transcription factor 4 — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[7] ↑ Activating transcription factor 4 — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Activating transcription factor 4 — RefSeq protein ID (P637): NP_077379. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Activating transcription factor 4 — RefSeq protein ID (P637): XP_038935870. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Activating transcription factor 4 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Activating transcription factor 4 — molecular function (P680): protein C-terminus binding. The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Activating transcription factor 4 — molecular function (P680): transcription factor binding. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Activating transcription factor 4 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Activating transcription factor 4 — molecular function (P680): leucine zipper domain binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Activating transcription factor 4 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Activating transcription factor 4 — cell component (P681): nucleus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Activating transcription factor 4 — cell component (P681): transcription regulator complex. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Activating transcription factor 4 — cell component (P681): cytoplasm. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Activating transcription factor 4 — cell component (P681): centrosome. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Activating transcription factor 4 — cell component (P681): microtubule organizing center. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Activating transcription factor 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Activating transcription factor 4. Retrieved May 3, 2026, from https://4ort.xyz/entity/activating-transcription-factor-4-q28562744

MLA

“Activating transcription factor 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/activating-transcription-factor-4-q28562744.

BibTeX

@misc{4ortxyz_activating-transcription-factor-4-q28562744_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Activating transcription factor 4}}, year = {2026}, url = {https://4ort.xyz/entity/activating-transcription-factor-4-q28562744}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Activating transcription factor 4 — https://4ort.xyz/entity/activating-transcription-factor-4-q28562744 (retrieved 2026-05-03)

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