Activating transcription factor 4

mammalian protein found in Mus musculus

Protein protein Q21981491

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Activating transcription factor 4

Summary

Activating transcription factor 4 is a protein^[1].

Key Facts

Activating transcription factor 4's instance of is recorded as protein^[2].
Activating transcription factor 4's UniProt protein ID is recorded as Q06507^[3].
Activating transcription factor 4's part of is recorded as cAMP-dependent transcription factor ATF-4^[4].
Activating transcription factor 4's part of is recorded as membrane protein^[5].
Activating transcription factor 4's part of is recorded as Basic-leucine zipper domain, protein family^[6].
Activating transcription factor 4's has part is recorded as Basic-leucine zipper domain^[7].
Activating transcription factor 4's RefSeq protein ID is recorded as NP_001274109^[8].
Activating transcription factor 4's RefSeq protein ID is recorded as NP_033846^[9].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[10].
Activating transcription factor 4's molecular function is recorded as protein heterodimerization activity^[11].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity^[12].
Activating transcription factor 4's molecular function is recorded as core promoter sequence-specific DNA binding^[13].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[14].
Activating transcription factor 4's molecular function is recorded as protein binding^[15].
Activating transcription factor 4's molecular function is recorded as DNA binding^[16].
Activating transcription factor 4's molecular function is recorded as sequence-specific DNA binding^[17].
Activating transcription factor 4's molecular function is recorded as leucine zipper domain binding^[18].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[19].
Activating transcription factor 4's molecular function is recorded as protein kinase binding^[20].
Activating transcription factor 4's molecular function is recorded as protein C-terminus binding^[21].
Activating transcription factor 4's molecular function is recorded as transcription factor binding^[22].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[23].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[24].
Activating transcription factor 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[25].
Activating transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Part of cAMP-dependent transcription factor ATF-4, membrane protein, Basic-leucine zipper domain, protein family

Properties

Biological process circadian rhythm, rhythmic process, response to manganese-induced endoplasmic reticulum stress, transcription, DNA-templated, positive regulation of neuron apoptotic process, mRNA transcription by RNA polymerase II, PERK-mediated unfolded protein response, gluconeogenesis, regulation of transcription by RNA polymerase II, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, cellular response to amino acid starvation, circadian regulation of gene expression, cellular response to glucose starvation, regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, negative regulation of oxidative stress-induced neuron death, response to endoplasmic reticulum stress, positive regulation of transcription, DNA-templated, positive regulation of gene expression, positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress, positive regulation of vascular endothelial growth factor production, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, cellular response to dopamine, response to toxic substance, neuron differentiation, cellular response to oxygen-glucose deprivation, gamma-aminobutyric acid signaling pathway, negative regulation of potassium ion transport, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, regulation of transcription by RNA polymerase II, cellular calcium ion homeostasis, positive regulation of biomineral tissue development, negative regulation of cold-induced thermogenesis, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, positive regulation of sodium-dependent phosphate transport

Cell component microtubule organizing center, membrane, transcription regulator complex, plasma membrane, cytoskeleton, cytoplasm, Lewy body core, ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, nuclear periphery, CHOP-ATF4 complex, neuron projection, nucleus, centrosome, protein-containing complex, dendrite membrane, nucleus, RNA polymerase II transcription regulator complex

Encoded by Atf4

Found in taxon house mouse

Has part(s) Basic-leucine zipper domain

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein heterodimerization activity, DNA-binding transcription factor activity, core promoter sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, DNA binding, sequence-specific DNA binding, leucine zipper domain binding, DNA-binding transcription factor activity, RNA polymerase II-specific, protein kinase binding, protein C-terminus binding, transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000105234, ENSMUSP00000155806

Refseq protein id NP_001274109, NP_033846

Uniprot protein id Q06507

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Activating transcription factor 4 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Activating transcription factor 4 — UniProt protein ID (P352): Q06507. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Activating transcription factor 4 — part of (P361): cAMP-dependent transcription factor ATF-4. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Activating transcription factor 4 — part of (P361): membrane protein. wikidata.org.
[6] ↑ Activating transcription factor 4 — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[7] ↑ Activating transcription factor 4 — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Activating transcription factor 4 — RefSeq protein ID (P637): NP_001274109. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Activating transcription factor 4 — RefSeq protein ID (P637): NP_033846. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Activating transcription factor 4 — molecular function (P680): protein heterodimerization activity. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Activating transcription factor 4 — molecular function (P680): core promoter sequence-specific DNA binding. cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Activating transcription factor 4 — molecular function (P680): protein binding. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Activating transcription factor 4 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Activating transcription factor 4 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Activating transcription factor 4 — molecular function (P680): leucine zipper domain binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Activating transcription factor 4 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Activating transcription factor 4 — molecular function (P680): protein C-terminus binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Activating transcription factor 4 — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Activating transcription factor 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Activating transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Activating transcription factor 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_activating-transcription-factor-4-q21981491_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Activating transcription factor 4}}, year = {2026}, url = {https://4ort.xyz/entity/activating-transcription-factor-4-q21981491}, note = {Accessed: 2026-05-03}}

LLM prompt

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