# Yorkie Dmel_CG4005

> protein found in Drosophila melanogaster

**Wikidata**: [Q29809694](https://www.wikidata.org/wiki/Q29809694)  
**Source**: https://4ort.xyz/entity/yorkie-dmel-cg4005


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q45VV3)
3. Q20641742
4. [The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
5. [Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
6. [The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
7. [SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
8. [The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
9. [In vivo regulation of Yorkie phosphorylation and localization.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
10. [Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
11. [Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
12. [The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
13. [The Hippo pathway regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
14. [Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
15. [Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
17. [The Hippo signaling pathway interactome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
18. [Opposite feedbacks in the Hippo pathway for growth control and neural fate.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
19. [The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
20. [Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
21. [The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
22. [Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
23. [dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
24. [The bantam microRNA is a target of the hippo tumor-suppressor pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
25. [Cooperative Regulation of Growth by Yorkie and Mad through bantam](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
26. [Regulation ofDrosophilaglial cell proliferation by Merlin-Hippo signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
27. [Hippo signaling regulatesDrosophilaintestine stem cell proliferation through multiple pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
28. [Yorkie promotes transcription by recruiting a histone methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
29. [Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
30. [Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3)
31. ensembl Release 106