# X-ray repair cross complementing 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116645](https://www.wikidata.org/wiki/Q21116645)  
**Source**: https://4ort.xyz/entity/x-ray-repair-cross-complementing-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12956)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/A0A024R1N4)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
6. [Ku binds telomeric DNA in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024R1N4)
9. [Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
10. [Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
11. [Ku complex interacts with and stimulates the Werner protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
12. [Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
13. [Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
14. [Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
15. [The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
16. [Heat shock factor 1, an inhibitor of non-homologous end joining repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
17. [A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
18. [DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
19. [DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
20. [Coilin interacts with Ku proteins and inhibits in vitro non‐homologous DNA end joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
21. [BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
22. [SIRT1 promotes DNA repair activity and deacetylation of Ku70](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
23. [A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
24. [Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
25. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
26. [A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
27. [Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
28. [Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
29. [Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
30. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
31. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
32. [Role of the translationally controlled tumor protein in DNA damage sensing and repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
33. [Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
34. [A role for the HOXB7 homeodomain protein in DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
35. [Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
36. [Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
37. [A role of DNA-PK for the metabolic gene regulation in response to insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
38. [Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
39. [Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
40. [Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
41. [Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
42. [Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
43. [Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
44. [Deformed Epidermal Autoregulatory Factor-1 (DEAF1) Interacts with the Ku70 Subunit of the DNA-Dependent Protein Kinase Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
45. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
46. [DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
47. [Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
48. [TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
49. [Interaction of human Ku70 with TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)
50. [TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956)