# X-ray repair cross complementing 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116582](https://www.wikidata.org/wiki/Q21116582)  
**Source**: https://4ort.xyz/entity/x-ray-repair-cross-complementing-5-q21116582


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P13010)
3. Q20641742
4. [Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
6. [Ku Binds Telomeric DNA in Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
7. [Human Ku70/80 Associates Physically with Telomerase through Interaction with hTERT](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13010&geneProductId=UniProtKB:P13010)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13010&geneProductId=UniProtKB:P13010)
9. [Ku is associated with the telomere in mammals](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13010&geneProductId=UniProtKB:P13010)
10. [Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
11. [Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
12. [Ku complex interacts with and stimulates the Werner protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
13. [The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
14. [DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
15. [Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
16. [PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
17. [Positive and Negative Modulation of the Transcriptional Activity of the ETS Factor ESE-1 through Interaction with p300, CREB-binding Protein, and Ku 70/86](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
18. [The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
19. [Regulation of Osteocalcin Gene Expression by a Novel Ku Antigen Transcription Factor Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
20. [A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
21. [WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
22. [Heat shock factor 1, an inhibitor of non-homologous end joining repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
23. [DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
24. [A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
25. [DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
26. [The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
27. [Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
28. [Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
29. [Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
30. [A Role for the HOXB7 Homeodomain Protein in DNA Repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
31. [Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
32. [Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
33. [A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
34. [Aire's Partners in the Molecular Control of Immunological Tolerance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
35. [Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
36. [APLF promotes the assembly and activity of non-homologous end joining protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
37. [Role of the translationally controlled tumor protein in DNA damage sensing and repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
38. [Ku70 and Poly(ADP-Ribose) Polymerase-1 Competitively Regulate β-Catenin and T-Cell Factor-4–Mediated Gene Transactivation: Possible Linkage of DNA Damage Recognition and Wnt Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
39. [Coilin interacts with Ku proteins and inhibits in vitro non‐homologous DNA end joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
40. [Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
41. [Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
42. [A role of DNA-PK for the metabolic gene regulation in response to insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
43. [Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
44. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
45. [Human Ku70/80 Associates Physically with Telomerase through Interaction with hTERT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
46. [TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
47. [The E3 ligase RNF8 regulates KU80 removal and NHEJ repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010)
48. [Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13010&geneProductId=UniProtKB:P13010)
49. [DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13010&geneProductId=UniProtKB:P13010)
50. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13010&geneProductId=UniProtKB:P13010)