# X-ray repair cross complementing 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112682](https://www.wikidata.org/wiki/Q21112682)  
**Source**: https://4ort.xyz/entity/x-ray-repair-cross-complementing-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13426)
3. Q20641742
4. [Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
5. [Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
6. [DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
7. [XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
8. [A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
9. [APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
10. [Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
11. [A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
12. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
14. [Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
15. [ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
16. [Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
17. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
18. [APLF promotes the assembly and activity of non-homologous end joining protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
19. [Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
20. [The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
21. [Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
22. [Crystal structure of an Xrcc4-DNA ligase IV complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
23. [Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
24. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
25. [Ku recruits XLF to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
26. [Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
27. [TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
28. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
29. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
30. [Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
31. [XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
32. [Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
33. [In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
34. [XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426)
35. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426)
36. [Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426)
37. [In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
39. [Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426)
40. [DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426)
41. [Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426)
42. Ensembl Release 99
43. Identifiers.org