# X-ray repair cross complementing 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q8042454](https://www.wikidata.org/wiki/Q8042454)  
**Source**: https://4ort.xyz/entity/x-ray-repair-cross-complementing-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P18887)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
5. [Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
6. [Aprataxin, a novel protein that protects against genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
7. [SIRT1 deacetylates APE1 and regulates cellular base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
8. [Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
9. [APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
10. [Characterization of the redox transition of the XRCC1 N-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
11. [S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
12. [A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
13. [Human DNA polymerase iota protects cells against oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
14. [The FHA domain of aprataxin interacts with the C-terminal region of XRCC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
15. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
16. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
17. [APLF promotes the assembly and activity of non-homologous end joining protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
18. [ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
19. [Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase   binding affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
20. [Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
21. [The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
22. [A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
23. [Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18887&geneProductId=UniProtKB:P18887)
25. [XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18887)
27. Ensembl Release 99
28. UMLS 2023