# X-linked inhibitor of apoptosis

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3408221](https://www.wikidata.org/wiki/Q3408221)  
**Source**: https://4ort.xyz/entity/x-linked-inhibitor-of-apoptosis-q3408221


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P98170)
3. Q20641742
4. [X-linked IAP is a direct inhibitor of cell-death proteases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98170&geneProductId=UniProtKB:P98170)
5. [XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
6. [X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
7. [cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
8. [Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
10. [The USP19 Deubiquitinase Regulates the Stability of c-IAP1 and c-IAP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
11. [A novel role for XIAP in copper homeostasis through regulation of MURR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
12. [Molecular interaction between HAX-1 and XIAP inhibits apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
13. [Survivin Monomer Plays an Essential Role in Apoptosis Regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
14. [The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
15. [Systematic Analysis of Dimeric E3-RING Interactions Reveals Increased Combinatorial Complexity in Human Ubiquitination Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
16. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
17. [Dual regulatory switch confers tighter control on HtrA2 proteolytic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
18. [HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
19. [Mechanism of XIAP-mediated inhibition of caspase-9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
20. [ARTS and Siah collaborate in a pathway for XIAP degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
21. [Structural Basis of Caspase Inhibition by XIAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
22. [S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
23. [Structural basis of caspase-7 inhibition by XIAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
24. [XIAP mediates NOD signaling via interaction with RIP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
25. [Structural basis of IAP recognition by Smac/DIABLO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
26. [Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
27. [Structural basis for the inhibition of caspase-3 by XIAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
28. [The MEKK 1 PHD ubiquitinates TAB 1 to activate MAPK s in response to cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
29. [Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
30. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
31. [IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
32. [IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
33. [Identification of a novel protein kinase Cδ–Smac complex that dissociates during paclitaxel‐induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
34. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
35. [SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
36. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
37. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
38. [Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
39. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
40. [A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
41. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
42. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98170&geneProductId=UniProtKB:P98170)
43. [XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98170&geneProductId=UniProtKB:P98170)
44. [X-linked IAP is a direct inhibitor of cell-death proteases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
46. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98170&geneProductId=UniProtKB:P98170)
47. [A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)
48. [A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98170&geneProductId=UniProtKB:P98170)
49. [cIAP1 Localizes to the nuclear compartment and modulates the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98170&geneProductId=UniProtKB:P98170)
50. [cIAP1 Localizes to the nuclear compartment and modulates the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170)