# X-box binding protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116794](https://www.wikidata.org/wiki/Q21116794)  
**Source**: https://4ort.xyz/entity/x-box-binding-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17861)
3. Q20641742
4. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
5. [Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP 1u](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
6. [XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
7. [Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
8. [A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
10. [Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
11. [Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
12. [XBP1 induces snail expression to promote epithelial- to-mesenchymal transition and invasion of breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
13. [An HLA-DR? promoter DNA-binding protein is expressed ubiquitously and maps to human chromosomes 22 and 5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
14. [A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
15. [Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
16. [The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
17. [XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
19. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
20. [Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
21. [Comprehensive identification of human bZIP interactions with coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
23. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
24. [pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
25. [Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
26. [Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
27. [XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
28. [Plasma cell differentiation requires the transcription factor XBP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
29. [Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
30. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
31. [Protective effect against Parkinson's disease-related insults through the activation of XBP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
32. [XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
33. [Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17861&geneProductId=UniProtKB:P17861)
34. [The endoplasmic reticulum stress response in aging and age-related diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
35. [MicroRNA‐214 Is Upregulated in Heart Failure Patients and Suppresses XBP1‐Mediated Endothelial Cells Angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
36. [Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17861)
37. Ensembl Release 99
38. UMLS 2023