# WT1 transcription factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118512](https://www.wikidata.org/wiki/Q21118512)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Wilms_tumor_protein)  
**Source**: https://4ort.xyz/entity/wt1-transcription-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19544)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q6PI38)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/E9PPW3)
5. Q20641742
6. [The Wilms' tumor suppressor gene WT1 is negatively autoregulated](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
7. [Repression of Pax-2 by WT1 during normal kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
8. [Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
9. [Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
11. [The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
12. [High affinity binding sites for the Wilms' tumour suppressor protein WT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
13. [Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
15. [PINCH1 Is Transcriptional Regulator in Podocytes That Interacts with WT1 and Represses Podocalyxin Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
16. [Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
17. [WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
18. [BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
19. [Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
20. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
21. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
22. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
24. [Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
25. [Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
26. [Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
27. [BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
28. [WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
29. [Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
30. [WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
31. [WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
32. [Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
33. [Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PI38)
35. [Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
36. [Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
37. [WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
38. [YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
39. [Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
40. [YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
41. [Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)
42. [Induction of Rb-associated Protein (RbAp46) by Wilms' Tumor Suppressor WT1 Mediates Growth Inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
43. [Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
44. [Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
45. [Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
46. [The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
47. [Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
48. [Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
49. [Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19544)
50. [Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19544&geneProductId=UniProtKB:P19544)