# Wingless-type MMTV integration site family, member 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q15321888](https://www.wikidata.org/wiki/Q15321888)  
**Source**: https://4ort.xyz/entity/wingless-type-mmtv-integration-site-family-member-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22724)
3. Q20641742
4. [Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
5. [The Wnts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
7. [Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724)
8. [Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
9. [sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
10. [Augmented Wnt signaling in a mammalian model of accelerated aging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
11. [Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724)
14. [Wnt family proteins are secreted and associated with the cell surface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
15. [Wnt4 inhibits cell motility induced by oncogenic Ras](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724)
16. [Wnt4 inhibits cell motility induced by oncogenic Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
17. [The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
18. [Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
19. [Requirement of Lim1 for female reproductive tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
20. [Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
21. [Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
22. [vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
23. [WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724)
24. [Wnt4 is required for proper male as well as female sexual development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
25. [Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
26. [WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
27. [Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
28. [Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
29. [Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
30. [Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
31. [Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
32. [A Role for WNT Proteins in Induction of Dermomyotome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
33. [Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
34. [HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
35. [Calcium/NFAT signalling promotes early nephrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
36. [WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
37. [Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
38. [Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
39. [Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
40. [PAX2 activates WNT4 expression during mammalian kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
41. [Female development in mammals is regulated by Wnt-4 signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
42. [Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
43. [Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
44. [Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
45. [SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
46. [Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
47. [Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
48. [Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724)
49. [Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724)
50. [Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724)