# Whirlin

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987608](https://www.wikidata.org/wiki/Q21987608)  
**Source**: https://4ort.xyz/entity/whirlin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q80VW5)
3. Q20641742
4. [Whirlin and PDZ Domain-containing 7 (PDZD7) Proteins Are Both Required to Form the Quaternary Protein Complex Associated with Usher Syndrome Type 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
5. [Whirlin complexes with p55 at the stereocilia tip during hair cell development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
6. [Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
7. [RpgrORF15 connects to the usher protein network through direct interactions with multiple whirlin isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
8. [Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
9. [Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
10. [Localization of PDZD7 to the Stereocilia Ankle-Link Associates this Scaffolding Protein with the Usher Syndrome Protein Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
11. [Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
12. [A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
13. [Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
15. [The small GTPase Rac1 regulates auditory hair cell morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
16. [Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
17. [Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
18. [Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
19. [Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
20. [Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
22. [A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
23. [Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
24. [Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
25. [Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
26. [Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
28. [Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
29. [Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
31. [Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
32. [The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
33. [Elongation of hair cell stereocilia is defective in the mouse mutant whirler](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
34. [Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
35. [Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
36. [Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80VW5&geneProductId=UniProtKB:Q80VW5)
37. [Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80VW5)
38. ensembl Release 106