# Werner syndrome RecQ like helicase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6591532](https://www.wikidata.org/wiki/Q6591532)  
**Source**: https://4ort.xyz/entity/werner-syndrome-recq-like-helicase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14191)
3. [UniProt](http://www.uniprot.org/uniprot/Q14191.txt?178)
4. [Swiss-Prot](http://www.uniprot.org/uniprot/Q14191.txt?version=180)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
7. [The Werner syndrome protein is a DNA helicase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
8. [WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
9. [Ku complex interacts with and stimulates the Werner protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
10. [Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
11. [The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
12. [The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
13. [Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
14. [Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
15. [Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
16. [The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
17. [Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
18. [Functional and physical interaction between WRN helicase and human replication protein A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
19. [Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
20. [Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
21. [The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
22. [Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
23. [Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
24. [Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
25. [Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
26. [WRN interacts physically and functionally with the recombination mediator protein RAD52](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
27. [A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
28. [Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
29. [p53 Modulates the exonuclease activity of Werner syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
30. [WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
31. [A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
32. [Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
33. [p53 modulates RPA-dependent and RPA-independent WRN helicase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
34. [Stimulation of flap endonuclease-1 by the Bloom's syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
35. [Physical and functional interaction of the Werner syndrome protein with poly‐ADP ribosyl transferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
36. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
37. [hPrimpol1/CCDC111 is a human DNA primase‐polymerase required for the maintenance of genome integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
38. [Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
39. [Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
40. [POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
41. [Characterization of the human and mouse WRN 3'-->5' exonuclease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
42. [The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
43. [Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
44. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191)
45. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
46. [Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
47. [Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
48. [Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
49. [Diverged nuclear localization of Werner helicase in human and mouse cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)
50. [WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191)