# WASP actin nucleation promoting factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q8027658](https://www.wikidata.org/wiki/Q8027658)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Wiskott–Aldrich_syndrome_protein)  
**Source**: https://4ort.xyz/entity/wasp-actin-nucleation-promoting-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42768)
3. Q20641742
4. [Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
5. [Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
6. [Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
7. [The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
8. [Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
9. [Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
10. [Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
11. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
12. [Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
13. [Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
14. [Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
15. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
16. [WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
17. [Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
18. [Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
19. [WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
20. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
21. [WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
22. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
23. [Phosphorylation of WASp is a key regulator of activity and stability in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
24. [Activation of endogenous Cdc42 visualized in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
25. [Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
26. [Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
27. [Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
30. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768)
31. [Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768)
32. [Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
33. [Nuclear ARP2/3 drives DNA break clustering for homology-directed repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
34. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
35. [Isolation of a novel gene mutated in Wiskott-Aldrich syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
36. [Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768)
37. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768)
38. Ensembl Release 99
39. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
40. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)