# VRK serine/threonine kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114346](https://www.wikidata.org/wiki/Q21114346)  
**Source**: https://4ort.xyz/entity/vrk-serine-threonine-kinase-2-q21114346


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q86Y07)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
5. [Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
6. [Identification of Two Novel Human Putative Serine/Threonine Kinases, VRK1 and VRK2, with Structural Similarity to Vaccinia Virus B1R Kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07)
8. [The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07)
9. [Characterization of three paralogous members of the Mammalian vaccinia related kinase family](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07)
10. [The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07)
11. [VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
12. [Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
13. [VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
14. [Identification of Two Novel Human Putative Serine/Threonine Kinases, VRK1 and VRK2, with Structural Similarity to Vaccinia Virus B1R Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
15. [The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
16. [Characterization of three paralogous members of the Mammalian vaccinia related kinase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
17. [The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
19. [Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
20. [Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07)
21. Ensembl Release 99