# Von Willebrand factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q412310](https://www.wikidata.org/wiki/Q412310)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Von_Willebrand_factor)  
**Source**: https://4ort.xyz/entity/von-willebrand-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04275)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
6. [150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
7. [Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
8. [The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
9. [ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
10. [Binding of ADAMTS13 to von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
11. [Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
12. [Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
13. [A pH-regulated dimeric bouquet in the structure of von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
14. [Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
15. [Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
16. [Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
17. [A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
18. [The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
19. [Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
20. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
21. [Allosteric activation of ADAMTS13 by von Willebrand factor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
22. [Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
23. [Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
24. [ADAMTS13 substrate recognition of von Willebrand factor A2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
25. [Mutations C1157F and C1234W of von Willebrand factor cause intracellular retention with defective multimerization and secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
26. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
27. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
28. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
29. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
30. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
31. [Biochemistry and genetics of von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
32. [Inducible secretion of large, biologically potent von Willebrand factor multimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
33. [Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
35. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
36. [A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
37. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
38. [Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
39. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
40. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
41. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
42. [Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275)
43. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
44. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
45. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
46. [Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
47. [Platelet and von Willebrand factor interactions at the vessel wall](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
48. [Shear-dependent changes in the three-dimensional structure of human von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
49. [von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)
50. [Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275)