# Von Hippel-Lindau tumor suppressor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7941454](https://www.wikidata.org/wiki/Q7941454)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Von_Hippel–Lindau_tumor_suppressor)  
**Source**: https://4ort.xyz/entity/von-hippel-lindau-tumor-suppressor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P40337)
3. Q20641742
4. [Regulation of the VHL/HIF-1 pathway by DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40337&geneProductId=UniProtKB:P40337)
5. [Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
6. [FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
8. [Ubiquitination of a Novel Deubiquitinating Enzyme Requires Direct Binding to von Hippel-Lindau Tumor Suppressor Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
9. [The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
10. [Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
11. [Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
12. [The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
13. [Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
14. [The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
15. [Regulation of the VHL/HIF-1 pathway by DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
16. [NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
17. [OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
18. [The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
19. [Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
20. [Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
21. [Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
22. [Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
23. [Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
24. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
25. [HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
26. [Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
27. [Cancer cells promote survival through depletion of the von Hippel-Lindau tumor suppressor by protein crosslinking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
28. [PKCzetaII is a target for degradation through the tumour suppressor protein pVHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
29. [Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
30. [VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
31. [Regulation of receptor for activated C kinase 1 protein by the von Hippel–Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
32. [A Y2H-seq approach defines the human protein methyltransferase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
33. [The HILDA Complex Coordinates a Conditional Switch in the 3′-Untranslated Region of the VEGFA mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
35. [Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
36. [Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40337&geneProductId=UniProtKB:P40337)
37. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40337&geneProductId=UniProtKB:P40337)
38. [Identification of novel VHL target genes and relationship to hypoxic response pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
39. [The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
40. [Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
41. [Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
42. [The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337)
43. [The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40337&geneProductId=UniProtKB:P40337)
44. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40337&geneProductId=UniProtKB:P40337)
45. Ensembl Release 99
46. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
47. UMLS 2023