# Vav guanine nucleotide exchange factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111121](https://www.wikidata.org/wiki/Q21111121)  
**Source**: https://4ort.xyz/entity/vav-guanine-nucleotide-exchange-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P15498)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
5. [Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
6. [vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15498&geneProductId=UniProtKB:P15498)
7. [Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
8. [Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
9. [Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
10. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
11. [Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
12. [c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
13. [Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
14. [The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
15. [The association of Sam68 with Vav1 contributes to tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
16. [Crucial structural role for the PH and C1 domains of the Vav1 exchange factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
17. [Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
18. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
19. [A protein domain-based interactome network for C. elegans early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
20. [Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
21. [Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
22. [Characterization of VIK-1: a new Vav-interacting Kruppel-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
23. [Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
24. [SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15498&geneProductId=UniProtKB:P15498)
26. [Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
27. [Radixin regulates cell migration and cell-cell adhesion through Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15498)
28. Ensembl Release 99